CH307889A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307889A CH307889A CH307889DA CH307889A CH 307889 A CH307889 A CH 307889A CH 307889D A CH307889D A CH 307889DA CH 307889 A CH307889 A CH 307889A
- Authority
- CH
- Switzerland
- Prior art keywords
- bactericidal
- salicylanilide
- preparation
- trifluoromethyl
- acid
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
<B>Verfahren</B> zur Herstellung <B>eines</B> hakteriziden Salieylanilides. Gegenstand vorliegenden Patentes ist ei-n Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch ge kennzeichnet, dass man 1 1M1 4,5-Dichlor- salieylsäure auf 1 illol 3-Trifluormethyl-4- chlor-anilin einwirken lässt.
Die erhaltene neue Verbindung, das 4,5 Dichlor-salicylsäure-3'-trifluormethyl-4'-chlor- anilid, schmilzt bei 225-226 . Sie soll als Desinfektionsmittel für nicht arzneiliche Zwecke Verwendung finden. <I>Beispiel:</I> 52 Teile 4,5-Dichlor-salicylsäure und 49 Teile 3-Trifluormethyl-4-chlor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein 'Teil Aluminiumchlorid und 15 'Teile Phosphortri- ehlorid zugegeben.
Diese Suspension wird so lange zum Sieden erhitzt, bis kein Chlor- wasserstoff mehr entweicht, was nach unge fähr 2-3 Stunden der Fall ist. Die chlorben- zolische Lösung wird dann mit Wasser ver mischt und mit Soda brillantalkalisch gestellt. Das Chlorbenzol wird mit Wasserdampf ab geblasen und der Destillationsrückstand, nach dem Abfiltrieren und Trocknen, aus Chlor benzol umkristallisiert.
Das erhaltene 4,5- Dichlor-salicylsäure-3'-tr ifluormethyl-4'-chlor- anilid schmilzt bei 225-226 .
<B> Process </B> for producing <B> a </B> bactericidal salieylanilide. The subject of the present patent is a process for the production of a bactericidal salicylanilide. The process is characterized in that 1 1M1 4,5-dichlorosalicic acid is allowed to act on 1 illol of 3-trifluoromethyl-4-chloro-aniline.
The new compound obtained, 4,5 dichlorosalicylic acid-3'-trifluoromethyl-4'-chloroanilide, melts at 225-226. It should be used as a disinfectant for non-medicinal purposes. <I> Example: </I> 52 parts of 4,5-dichlorosalicylic acid and 49 parts of 3-trifluoromethyl-4-chloro-aniline are dissolved in 450 parts of chlorobenzene, and one part of aluminum chloride and 15 parts of phosphorus trichloride are added.
This suspension is heated to the boil until no more hydrogen chloride escapes, which is the case after about 2-3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda. The chlorobenzene is blown off with steam and the distillation residue, after filtering off and drying, recrystallized from chlorobenzene.
The 4,5-dichlorosalicylic acid-3'-trifluoromethyl-4'-chloroanilide obtained melts at 225-226.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH307889T | 1951-12-29 | ||
| CH304558T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307889A true CH307889A (en) | 1955-06-15 |
Family
ID=25734858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307889D CH307889A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307889A (en) |
-
1951
- 1951-12-29 CH CH307889D patent/CH307889A/en unknown
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