CH307880A - Process for the preparation of a bactericidal salicylanilide. - Google Patents
Process for the preparation of a bactericidal salicylanilide.Info
- Publication number
- CH307880A CH307880A CH307880DA CH307880A CH 307880 A CH307880 A CH 307880A CH 307880D A CH307880D A CH 307880DA CH 307880 A CH307880 A CH 307880A
- Authority
- CH
- Switzerland
- Prior art keywords
- salicylanilide
- bactericidal
- preparation
- chloro
- salicylic acid
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung eines bakteriziden Salieylanilides. Gegenstand vorliegenden Patentes ist ein Verfahren zur Herstellung eines bakteriziden Salicylanilides. Das Verfahren ist dadurch gekennzeichnet, dass man 1 Mol 5-Chlor- salicylsäure auf 1 Mol 3,1,5-Triehlor-anilin einwirken lässt.
Die erhaltene neue Verbindung, das 5 - Chlor.- salicylsäure - 3', 4', 5'-¯tiichlor-anilid, schmilzt bei 283-284 . Sie soll als Desinfek tionsmittel für nicht arzneiliche Zwecke Ver wendung finden.
<I>Beispiel:</I> 43 Teile 5-Chlor-salicylsäure und 50 Teile 3,4,5-Triehlor-anilin werden in 450 Teilen Chlorbenzol gelöst und ein Teil Aluminium chlorid und 15 Teile Phosphortrichlorid zu gegeben. Diese Suspension wird so lange zum Sieden erhitzt, bis kein Chlorwasserstoff mehr entweicht, was nach ungefähr 2-3 Stunden der Fall ist. Die chlorbenzolische Lösung wird dann mit Wasser vermischt und mit Soda brillantalkalisch gestellt. Das Chlorbenzol wird mit Wasserdampf abgeblasen und der Destillationsrüekstand, nach dem Abfiltrieren und Trocknen, aus Chlorbeüzol umkristallisiert.
Das erhaltene 5-Chlor-sa.licylsäure-3',4',5'- trichlor-anilid schmilzt bei 283-284 .
Process for the preparation of a bactericidal salieylanilide. The present patent relates to a process for the preparation of a bactericidal salicylanilide. The process is characterized in that 1 mol of 5-chlorosalicylic acid is allowed to act on 1 mol of 3,1,5-triehloro aniline.
The new compound obtained, 5 - chloro-salicylic acid - 3 ', 4', 5'-¯tiichloro-anilide, melts at 283-284. It should be used as a disinfectant for non-medicinal purposes.
<I> Example: </I> 43 parts of 5-chloro-salicylic acid and 50 parts of 3,4,5-triehloro-aniline are dissolved in 450 parts of chlorobenzene and one part of aluminum chloride and 15 parts of phosphorus trichloride are added. This suspension is heated to the boil until no more hydrogen chloride escapes, which is the case after about 2-3 hours. The chlorobenzene solution is then mixed with water and made brilliantly alkaline with soda. The chlorobenzene is blown off with steam and the residue from the distillation, after filtering off and drying, is recrystallized from chlorobenzene.
The 5-chloro-sa.licylic acid-3 ', 4', 5'-trichloro-anilide obtained melts at 283-284.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH307880T | 1951-12-29 | ||
| CH304558T | 1951-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH307880A true CH307880A (en) | 1955-06-15 |
Family
ID=25734849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH307880D CH307880A (en) | 1951-12-29 | 1951-12-29 | Process for the preparation of a bactericidal salicylanilide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH307880A (en) |
-
1951
- 1951-12-29 CH CH307880D patent/CH307880A/en unknown
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