CH189752A - Process for the preparation of triphenylacetic acid-2-diethylaminoethanol ester. - Google Patents
Process for the preparation of triphenylacetic acid-2-diethylaminoethanol ester.Info
- Publication number
- CH189752A CH189752A CH189752DA CH189752A CH 189752 A CH189752 A CH 189752A CH 189752D A CH189752D A CH 189752DA CH 189752 A CH189752 A CH 189752A
- Authority
- CH
- Switzerland
- Prior art keywords
- diethylaminoethanol
- acid
- ester
- triphenylacetic acid
- triphenylacetic
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von Triphenylessigsäure-2-diäthylaininoäthanolester. Es wurde gefunden, dass man zu dem im Patente Nr. 187247 beschriebenen Triphenyl- ersigsäure-2-diäthylaminoäthanolester gelan gen kann, wenn man auf ein Metallsalz der Triphenylessigsäure einen reaktionsfähigen Ester des Diäthylaminoäthanols einwirken lässt.
Die ;so erhaltene Verbindung soll thera peutische Verwendung finden.
<I>Beispiel:</I> 21 Teile Triphenylessigsäure, 18 Teile Chloräthyldiäthylamin-hydrochlorid, 25 Teile lialiumkarbonat und 100 Teile Aceton wer den am Rückfluss bis zur beendeten Reak tion gekocht. Nach dem Abkühlen wird fil triert, mit Aceton gewaschen und das einge- dampfte Filtrat in Äther aufgenommen.
Die %-therlösung wird mit verdünnter Natrium karbonatlösung gewaschen und über Kalium- karbonatgetrocknet. Nach dem Verdampfen iles Äthers erhält man den Triphenylessig- säure-2-diäthylaminoäthanolester als<B>01,</B> das im Hochvakuum fraktioniert werden kann.
Dieselbe Verbindung kann auch gewon nen werden, wenn man zum Beispiel an Stelle von Kaliumkarbonat ein anderes Alkalikar- bonat verwendet, oder wenn man ein fertiges Alkali- oder anderes Metallsalz der Tri- phenylessigsäure mit Chloräthyldiäthylamin umsetzt.
Statt diesem können auch Ester des Diäthy laminoäthanols mit andern Halogen wasserstoffsäuren oder mit Arylsulfonsäuren wie zum Beispiel Toluolsulfonsäure verwen det werden.
Process for the preparation of triphenylacetic acid-2-diethylaininoethanol ester. It has been found that the triphenylacetic acid-2-diethylaminoethanol ester described in patent no. 187247 can be obtained if a reactive ester of diethylaminoethanol is allowed to act on a metal salt of triphenylacetic acid.
The compound obtained in this way is intended to be used therapeutically.
<I> Example: </I> 21 parts of triphenylacetic acid, 18 parts of chloroethyldiethylamine hydrochloride, 25 parts of lialium carbonate and 100 parts of acetone who are refluxed until the reaction has ended. After cooling, it is filtered, washed with acetone and the evaporated filtrate is taken up in ether.
The% -therlösung is washed with dilute sodium carbonate solution and dried over potassium carbonate. After evaporation of the ether, the triphenyl acetic acid-2-diethylaminoethanol ester is obtained as 01, which can be fractionated in a high vacuum.
The same compound can also be obtained if, for example, another alkali metal carbonate is used instead of potassium carbonate, or if a finished alkali or other metal salt of triphenylacetic acid is reacted with chloroethyl diethylamine.
Instead of this, diethylaminoethanol esters with other hydrogen halides or with arylsulfonic acids such as toluenesulfonic acid can also be used.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH189752T | 1934-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH189752A true CH189752A (en) | 1937-03-15 |
Family
ID=4436512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH189752D CH189752A (en) | 1934-11-13 | 1934-11-13 | Process for the preparation of triphenylacetic acid-2-diethylaminoethanol ester. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH189752A (en) |
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1934
- 1934-11-13 CH CH189752D patent/CH189752A/en unknown
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