CH199676A - Process for the preparation of a substituted thiazolecarboxamide. - Google Patents
Process for the preparation of a substituted thiazolecarboxamide.Info
- Publication number
- CH199676A CH199676A CH199676DA CH199676A CH 199676 A CH199676 A CH 199676A CH 199676D A CH199676D A CH 199676DA CH 199676 A CH199676 A CH 199676A
- Authority
- CH
- Switzerland
- Prior art keywords
- thiazole
- reaction
- dicarboxylic acid
- diethylamine
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Verfahren zur Herstellung eines substituierten Thiazolearbonsäureamides. Gegenstand der vorliegenden Erfindung bildet ein Verfahren zur Herstellung eines substituierten Thiazolearbo@nsäureamids, wel- ches dadurch. gekennzeichnet ist, dass man auf eine Verbindung, .die das Radikal .der Formel
EMI0001.0005
besitzt, wie z. B. Thiazol-4,5-,dicarbonsäure, ihre iSalze, Hadogenide, Ester oder ihr An hydrid, Diäthylamin einwirken lässt.
Das so .gewonnene Thiazol-4,5=dicarbon- säure-bis-,diäthyla.mid bildet Kristalle vom F. 44 .
Die neue Verbindung soll therapeutische Verwendung finden.
<I>Beispiel:</I> 210 Teile Thiazol - 4,5 - ,dicarbonsäuredi- chlorid (dargestellt aus Thiazol-4,5,dicarbon- säure durch Erwärmen mit Thionylchlorid) erhitzt man mit 110 Teilen Diäthylamin- hydroehlorid, aus dem sich während der Reaktion Diäthylamin bildet, während zwei .Stunden auf<B>160'</B> C.
Die erhaltene :Schmelze wird in Wasser gelöst, mit konzentrierter Alkalilauge versetzt und mit Äther ausge schüttelt. Die ätherische Lösung wind über Atzkali getrocknet, eingedampft und durch Destillation ,des Rückstandes Thiazol-4,5-di- carbonsäure - bis -,diäthylamid vom F. 44 (karr.) erhalten.
Die Umsetzung kann auch in Gegenwart von Kondensationsmitteln, so wie von säurebindenden Mitteln vorgenom men werden.
An Stelle von Diäthylaminhydrochlorid kann ebensogut ein anderes Salz oder Di- äthylamin selbst verwendet werden.
Process for the preparation of a substituted thiazolearboxamide. The subject matter of the present invention is a process for the production of a substituted thiazolearbo @ nsäureamids, which thereby. is characterized by referring to a compound that contains the radical of the formula
EMI0001.0005
owns such. B. thiazole-4,5-, dicarboxylic acid, its iSalts, hadogenides, esters or their hydride, diethylamine can act.
The thiazole-4,5 = dicarboxylic acid-bis-, diethyla.mid obtained in this way forms crystals of F. 44.
The new compound should find therapeutic use.
<I> Example: </I> 210 parts of thiazole 4,5 dicarboxylic acid dichloride (prepared from thiazole 4,5 dicarboxylic acid by heating with thionyl chloride) are heated with 110 parts of diethylamine hydrochloride, from which During the reaction diethylamine forms, for two hours to <B> 160 '</B> C.
The obtained: melt is dissolved in water, mixed with concentrated alkali and shaken out with ether. The ethereal solution is dried over caustic potash, evaporated and, by distillation, the residue thiazole-4,5-dicarboxylic acid - bis -, diethylamide from F. 44 (Karr.) Obtained.
The reaction can also be carried out in the presence of condensing agents, such as acid-binding agents.
Instead of diethylamine hydrochloride, another salt or diethylamine itself can just as well be used.
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH199676T | 1936-06-20 | ||
CH192930T | 1943-03-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH199676A true CH199676A (en) | 1938-08-31 |
Family
ID=25722352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH199676D CH199676A (en) | 1936-06-20 | 1936-06-20 | Process for the preparation of a substituted thiazolecarboxamide. |
Country Status (1)
Country | Link |
---|---|
CH (1) | CH199676A (en) |
-
1936
- 1936-06-20 CH CH199676D patent/CH199676A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CH199676A (en) | Process for the preparation of a substituted thiazolecarboxamide. | |
DE668874C (en) | Process for the preparation of substituted thiazolecarboxamides | |
CH242287A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH192930A (en) | Process for the preparation of a substituted thiazolecarboxamide. | |
CH240162A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH221219A (en) | Process for the preparation of a basic ester. | |
CH240167A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH242288A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH183065A (en) | Process for the preparation of benzilic acid-2-diethylaminoethanol ester. | |
CH185061A (en) | Process for the preparation of a substituted amide of a fatty aromatic acid. | |
CH179697A (en) | Process for the preparation of 1-tropic acid-2,2-dimethyl-3-dimethylaminopropanol ester. | |
CH199982A (en) | Process for the preparation of a new ester. | |
CH242289A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH220973A (en) | Process for the preparation of a basic ester. | |
CH269409A (en) | Process for the representation of a basic ether. | |
CH139418A (en) | Process for the preparation of a one-sided heterocyclically acylated diamine. | |
CH247927A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH192777A (en) | Process for the preparation of a substituted pyridine-o-dicarboxamide. | |
CH192779A (en) | Process for the preparation of a substituted pyridine-o-dicarboxamide. | |
CH247926A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH235515A (en) | Process for the preparation of tetrahydropyran-4,4-dicarboxylic acid-bis-diethylamide. | |
CH311592A (en) | Process for making a new salt. | |
CH240164A (en) | Process for the preparation of a basic ester of a 1-aryl-cycloalkyl-1-carboxylic acid. | |
CH188236A (en) | Process for the preparation of a urethane of pyridine-3-carboxylic acid. | |
CH245908A (en) | Process for the preparation of a basic amide of a 1-aryl-cycloalkyl-1-carboxylic acid. |