CH164093A - Process for the preparation of an asymmetric arsenobenzene compound. - Google Patents

Process for the preparation of an asymmetric arsenobenzene compound.

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Publication number
CH164093A
CH164093A CH164093DA CH164093A CH 164093 A CH164093 A CH 164093A CH 164093D A CH164093D A CH 164093DA CH 164093 A CH164093 A CH 164093A
Authority
CH
Switzerland
Prior art keywords
arsenobenzene
compound
preparation
asymmetric
water
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH164093A publication Critical patent/CH164093A/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Herstellung einer asymmetrischen     Arsenobenzolverbindung.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Herstellung einer     asynr-          rnetrischen        Arsenobenzolverbindung,    welches  dadurch gekennzeichnet ist, dass man<B>2.5.</B>     5'-          Trichlor-4.        3'-diacetylamino-4'-        oxy-1.        1'-arse-          nobenzol    mit einem     Mol    Halogenessigsäure  umsetzt.  



  Das neue Verfahrensprodukt ist ein hell  gelbes, in Wasser klar und mit neutraler  Reaktion lösliches Pulver. Die     Lösung    hat  den Vorzug, haltbar und sowohl bei intra  venöser als auch bei subkutaner beziehungs  weise intramuskulärer Injektion gut wirksam  und sehr gut verträglich zu sein.  



  <I>Beispiel:</I>  27 g der     Arsenoverbindung    aus     2.5-Di--          chlor--4-acetylamirropherryl-l-arsinsäur e    und  3 -     Acetylamino-    4-     oxy-5-chlorphenyl        -1-arsin-          säure    werden in 300 cm-' Wasser von<B>35'</B>  unter Zusatz von 12     cm3    10 n-Kalium-         hydroxydlösung    gelöst.

   Dann gibt man eine  Lösung von 6 g     Monochloressigsäure    und  4 g Natriumkarbonat irr 50 cm' Wasser zu,  füllt das Gefäss mit Stickstoff, verschliesst  es und lässt es unter     öfterem        Umschütteln     48 Stunden bei     300    stehen. Dann wird mit  Eisessig versetzt; der Niederschlag abgesaugt  und ausgewaschen. Die noch feuchte     Arseno-          verbindung    wird in wenig Wasser durch  tropfenweisen Zusatz von     Natriumhydroxyd-          lösung    in Lösung gebracht.

   Man filtriert in  kaltem Alkohol und erhält durch Absaugen  des Niederschlages das     Natriumsalz    des  2 .5 . 5' -     Trichlor    - 4 . 3' -     diacetylamino    -4'     -oxy-          essigsäure-1.1'-arsenobenzols    als hellgelbes,  in Wasser äusserst leicht lösliches körniges  Pulver.



  Process for the preparation of an asymmetric arsenobenzene compound. The present invention relates to a process for the production of an asynchronous arsenobenzene compound which is characterized in that <B> 2.5. </B> 5′-trichloro-4. 3'-diacetylamino-4'-oxy-1. 1'-arsenobenzene is reacted with one mole of haloacetic acid.



  The new process product is a light yellow powder that is clear in water and soluble with a neutral reaction. The solution has the advantage of being durable and very effective and very well tolerated both by intravenous and subcutaneous or intramuscular injection.



  <I> Example: </I> 27 g of the arsenic compound from 2.5-dichloro-4-acetylamirropherryl-1-arsic acid and 3-acetylamino-4-oxy-5-chlorophenyl-1-arsic acid are in 300 cm- 'water of <B> 35' </B> with the addition of 12 cm3 of 10 n-potassium hydroxide solution.

   A solution of 6 g of monochloroacetic acid and 4 g of sodium carbonate is then added in 50 cm of water, the vessel is filled with nitrogen, closed and left to stand at 300 for 48 hours, shaking frequently. Then glacial acetic acid is added; the precipitate sucked off and washed out. The still moist arsenic compound is dissolved in a little water by the dropwise addition of sodium hydroxide solution.

   It is filtered in cold alcohol and the sodium salt of 2.5 is obtained by suctioning off the precipitate. 5 '- trichloro - 4. 3 '- diacetylamino -4' -oxyacetic acid-1.1'-arsenobenzene as a light yellow, granular powder which is extremely easily soluble in water.

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung einer asynr- rnetrischen Arsenobenzolverbindung, dadurch gekennzeichnet, dass man 2.5.5'-Trichlor- 4. 3'-diacetylamino - 4'-oxy-1 .1'- arsenobenzol mit einem Mol Halogenessigsäure umsetzt. Das neue Verfahrensprodukt ist ein hell gelbes, in Wasser klar und mit neutraler Reaktion lösliches Pulver. Die Lösung hat den Vorzug, haltbar und sowohl bei intra- venöser als auch bei subkutaner beziehungs weise intramuskulärer Injektion gut wirksam und sehr gut verträglich zu sein. PATENT CLAIM Process for the preparation of an asynchronous arsenobenzene compound, characterized in that 2.5.5'-trichloro-4. 3'-diacetylamino-4'-oxy-1 .1'-arsenobenzene is reacted with one mole of haloacetic acid. The new process product is a light yellow powder that is clear in water and soluble with a neutral reaction. The solution has the advantage of being durable and very effective and very well tolerated by intravenous as well as subcutaneous or intramuscular injection.
CH164093D 1931-02-20 1932-02-19 Process for the preparation of an asymmetric arsenobenzene compound. CH164093A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE164093X 1931-02-20
CH160578T 1932-02-19

Publications (1)

Publication Number Publication Date
CH164093A true CH164093A (en) 1933-09-15

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ID=25717351

Family Applications (1)

Application Number Title Priority Date Filing Date
CH164093D CH164093A (en) 1931-02-20 1932-02-19 Process for the preparation of an asymmetric arsenobenzene compound.

Country Status (1)

Country Link
CH (1) CH164093A (en)

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