CH161241A - Process for the preparation of the acetic acid ester of 3-glycolylamino-4-oxybenzene-1-arsic acid. - Google Patents

Process for the preparation of the acetic acid ester of 3-glycolylamino-4-oxybenzene-1-arsic acid.

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Publication number
CH161241A
CH161241A CH161241DA CH161241A CH 161241 A CH161241 A CH 161241A CH 161241D A CH161241D A CH 161241DA CH 161241 A CH161241 A CH 161241A
Authority
CH
Switzerland
Prior art keywords
oxybenzene
arsic
acid
preparation
glycolylamino
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH161241A publication Critical patent/CH161241A/en

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Description

  

  Verfahren zur Darstellung des     Essigsäureesters    der     3-Glykolylamino-4-ogybenzol-l-          arsinsäure.            (xegenstand    der vorliegenden Erfindung  ist ein Verfahren zur Darstellung des     Essig-          säureesters    der     3-Glykolylamino-4-oxybenzol-          1-arsinsäure,    welches dadurch gekennzeichnet  ist, dass man     3-Amino-4-oxybenzol-l-arsinsäure     mit     Acetylglykolsäurechlorid    umsetzt.  



  Das neue Verfahrensprodukt bildet feine  Nadeln, F. 214-2150 C, ist schwer löslich  in Wasser, leichter in Äthylalkohol, leicht  löslich in Methylalkohol. Es zeichnet sich  bei geringer Toxizität durch sehr gute Wir  kung speziell bei     Trypanosomenkrankheiten     <B>aus.</B>  



  <I>Beispiel:</I>  23,3     gr        3-Arnino-4-oxybenzol-l-arsinsäure          werden    in 200     cm3        n-Natronlauge    gelöst, die  Lösung auf 0   C abgekühlt und 15     gr        Ace-          tylglykolsäurechlorid        zutropfen    gelassen. Wäh  rend der Umsetzung hält man mit Natron  lauge alkalisch. Die alsdann mit Salzsäure  abgeschiedene 3-(Acetylglykolyl)-amino-4-oxy-         benzol-l-arsinsäure    wird aus Wasser umkri  stallisiert. Aasbeute 25     gr    feine Nadeln, die  bei 214-2160 C schmelzen.

   Schwer löslich  in Wasser, leichter in Äthylalkohol, leicht  löslich in Methylalkohol.



  Process for the preparation of the acetic acid ester of 3-glycolylamino-4-ogybenzene-l-arsic acid. (The subject matter of the present invention is a process for the preparation of the acetic acid ester of 3-glycolylamino-4-oxybenzene-1-arsic acid, which is characterized in that 3-amino-4-oxybenzene-1-aric acid is reacted with acetylglycolic acid chloride.



  The new process product forms fine needles, F. 214-2150 C, is sparingly soluble in water, more easily in ethyl alcohol, easily soluble in methyl alcohol. It is characterized by its low toxicity and its very good effect, especially in trypanosomal diseases <B>. </B>



  <I> Example: </I> 23.3 g of 3-amino-4-oxybenzene-1-arsic acid are dissolved in 200 cm3 of sodium hydroxide solution, the solution is cooled to 0 ° C. and 15 g of acetylglycolic acid chloride are added dropwise. During the implementation you keep alkaline with sodium hydroxide solution. The 3- (acetylglycolyl) -amino-4-oxybenzene-1-arsic acid then separated with hydrochloric acid is recrystallized from water. Carcassage 25 grams of fine needles that melt at 214-2160 C.

   Slightly soluble in water, more easily in ethyl alcohol, slightly soluble in methyl alcohol.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung des Essigsäure- esters der 3-Glykolylamirio-4-oxybenzol-l- arsinsäure, dadurch gekennzeichnet, dass man 3-Amino-4-oxybenzol-1.-arsinsäure mit Acetyl- glykolsäurechlorid umsetzt. Das neue Verfahrensprodukt bildet feine Nadeln, F. 214-215 C, ist schwer löslich in Wasser, leichter in Äthylalkohol, leicht löslich in Methylalkohol. Es zeichnet sich bei geringer Toxizität durch sehr gute Wir kung speziell bei Trypanosomenkrankheiten aus. PATENT CLAIM: Process for the preparation of the acetic acid ester of 3-glycolylamirio-4-oxybenzene-l-arsic acid, characterized in that 3-amino-4-oxybenzene-1-arsic acid is reacted with acetylglycolic acid chloride. The new process product forms fine needles, F. 214-215 C, is sparingly soluble in water, more easily in ethyl alcohol, easily soluble in methyl alcohol. It is characterized by its low toxicity and its very good effect, especially in the case of trypanosomal diseases.
CH161241D 1931-07-14 1931-07-14 Process for the preparation of the acetic acid ester of 3-glycolylamino-4-oxybenzene-1-arsic acid. CH161241A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH158386T 1931-07-14
DE161241X 1941-12-16

Publications (1)

Publication Number Publication Date
CH161241A true CH161241A (en) 1933-04-15

Family

ID=25717102

Family Applications (1)

Application Number Title Priority Date Filing Date
CH161241D CH161241A (en) 1931-07-14 1931-07-14 Process for the preparation of the acetic acid ester of 3-glycolylamino-4-oxybenzene-1-arsic acid.

Country Status (1)

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CH (1) CH161241A (en)

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