CH161243A - Process for the preparation of the crotonic acid ester of 4-lactylamino-2-methylbenzene-1-arsic acid. - Google Patents

Process for the preparation of the crotonic acid ester of 4-lactylamino-2-methylbenzene-1-arsic acid.

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Publication number
CH161243A
CH161243A CH161243DA CH161243A CH 161243 A CH161243 A CH 161243A CH 161243D A CH161243D A CH 161243DA CH 161243 A CH161243 A CH 161243A
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CH
Switzerland
Prior art keywords
methylbenzene
acid
preparation
arsic
lactylamino
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH161243A publication Critical patent/CH161243A/en

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Description

  

  Verfahren zur Darstellung des     Crotonsäureesters    der     4-Lactylamino-2-methylbenzol-          1-arsinsäure.            Gegenstand    der vorliegenden Erfindung ist  ein Verfahren zur Darstellung des     Croton-          säureesters    der     4-Lactylaniino-2-metliylbenzol-          1-arsinsäure,    welches dadurch gekennzeichnet  ist, dass man     4-Amiiio-2-methylbenzol-l-arsin-          säure    mit     Orotonylmilchsäurechlorid    umsetzt.  



  Das neue Verfahrensprodukt bildet aus  Wasser oder einem wässerigen Alkohol um  kristallisierbare Kristalle, F.<B>164-1660</B> C,  ist schwer löslich in Wasser, leicht löslich  in Äthyl- und Methylalkohol und zeichnet sich  durch sehr gute Wirkung bei     Trypanosomen-          krankheiten    aus.  



  <I>Beispiel:</I>  46 g     2-Methyl-4-aminobenzol-l-ai-sinsäiire     werden in 400     oms        n-Natronlauge    gelöst und  die Lösung bei 0   C mit 40     gr        Crotonyl-          milchsäurechlorid    umgesetzt. Während der  Umsetzung hält man mit     120em'    2     n-Natron-          lauge        curcuma-alkalisch.    Man klärt mit Tier  kohle und säuert mit Salzsäure kongosauer       8,n.    Die 4-(Crotonyllactyl)-amino-2-nmethyl-         benzol-l-arsinsäure    scheidet sich als Kristalle  aus Wasser oder Alkoholwasser ab.

   Ausbeute  40     gr.    Schwer löslich in Wasser,     leicht     löslich in Äthyl- und Methylalkohol. F.164 bis  <B>166</B>   C.



  Process for the preparation of the crotonic acid ester of 4-lactylamino-2-methylbenzene-1-arsic acid. The present invention relates to a process for the preparation of the crotonic acid ester of 4-lactylaniino-2-methylbenzene-1-arsinic acid, which is characterized in that 4-amino-2-methylbenzene-1-arsic acid is reacted with orotonyl lactic acid chloride.



  The new process product forms crystallizable crystals from water or an aqueous alcohol, F. <B> 164-1660 </B> C, is sparingly soluble in water, easily soluble in ethyl and methyl alcohol and is characterized by its very good effect on trypanosomes - diseases.



  <I> Example: </I> 46 g of 2-methyl-4-aminobenzene-1-ai-sinsäiire are dissolved in 400 oms of sodium hydroxide solution and the solution is reacted at 0 C with 40 g of crotonyl lactic acid chloride. During the reaction, 1 2 N sodium hydroxide solution is used to keep curcuma-alkaline. It is clarified with animal charcoal and acidified with hydrochloric acid Congo acid 8, n. The 4- (crotonyllactyl) -amino-2-nmethyl-benzene-1-arsic acid separates out as crystals from water or alcohol water.

   Yield 40 gr. Slightly soluble in water, easily soluble in ethyl and methyl alcohol. F.164 to <B> 166 </B> C.

Claims (1)

PATENTANSPRU0H: Verfahren zur Darstellung des Crotonsäure- esters der 4-Lactylamino-Z-methylbenzol-l- arsinsäure, dadurch gekennzeichnet, dass man 4-Amino-2-methylbenzol-l-arsinsäui-e mit Cro- tonylmilchsäurechlorid umsetzt. Das neue Verfahrensprodukt bildet aus Wasser oder einem wässerigen Alkohol um kristallisierbare Kristalle, F. 164-166 C, ist schwer löslich in Wasser, leicht löslich in Äthyl- und Methylalkohol und zeichnet sich durch sehr gute Wirkung bei Trypanosomen- krankheiten aus. PATENT APPLICATION: Process for the preparation of the crotonic acid ester of 4-lactylamino-Z-methylbenzene-l-arsic acid, characterized in that 4-amino-2-methylbenzene-l-arsinic acid is reacted with crotonyl lactic acid chloride. The new process product forms from water or an aqueous alcohol around crystallizable crystals, mp 164-166 C, is sparingly soluble in water, easily soluble in ethyl and methyl alcohol and is characterized by its very good effect on trypanosomal diseases.
CH161243D 1930-07-19 1931-07-14 Process for the preparation of the crotonic acid ester of 4-lactylamino-2-methylbenzene-1-arsic acid. CH161243A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE161243X 1930-07-19
CH158386T 1931-07-14

Publications (1)

Publication Number Publication Date
CH161243A true CH161243A (en) 1933-04-15

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ID=25717104

Family Applications (1)

Application Number Title Priority Date Filing Date
CH161243D CH161243A (en) 1930-07-19 1931-07-14 Process for the preparation of the crotonic acid ester of 4-lactylamino-2-methylbenzene-1-arsic acid.

Country Status (1)

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CH (1) CH161243A (en)

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