CH161242A - Process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsic acid. - Google Patents

Process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsic acid.

Info

Publication number
CH161242A
CH161242A CH161242DA CH161242A CH 161242 A CH161242 A CH 161242A CH 161242D A CH161242D A CH 161242DA CH 161242 A CH161242 A CH 161242A
Authority
CH
Switzerland
Prior art keywords
acid
preparation
lactylaminobenzene
arsic
acetic acid
Prior art date
Application number
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH161242A publication Critical patent/CH161242A/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung des     Essigsäureesters    der.     4-Laetylaminobenzol-l-arsinsäure.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Darstellung des     Essig-          säureesters    der     4-Lactylaminobenzol-l-arsin-          säure,    welches dadurch gekennzeichnet ist,  dass man     4-Aminobenzol-l-ai-sinsäure    mit       Acetylmilähsäurechloi-id    umsetzt.  



  Das neue Verfahrensprodukt bildet feine  Kristalle, die aus heissem Wasser     umkristal-          lisierbar    sind und bis 280   C nicht schmelzen.  Es ist schwer löslich in Wasser, leicht lös  lich in Äthyl- und Methylalkohol und zeichnet  sich durch sehr gute Wirkung speziell bei       Trypanosomenkrankheiten    aus.  



  <I>Beispiel:</I>  43     gr        p-Arsanilsäure    werden in 200     cm3     Wasser und<B>150</B>     cm3    2     n-Natronlauge    gelöst,  die Lösung auf 0  C abgekühlt und 32     gr          Acetylmilcheäurechlorid        zutropfen    gelassen.

    Während der Umsetzung hält man mit 120     cm3     2     n-Natronlauge    auf     Anfangsalkalität.    Auf  Zusatz von Salzsäure bis zur kongosauren    Reaktion scheidet sich die     4-(Acetyllactyl)-          aminobenzol-l-arsinsäure    in feinen Kristallen  ab, die aus 800 cm' heissem Wasser umkri  stallisiert werden. Ausbeute 40     gr.    Schwer  löslich in Wasser, leicht löslich in     Äthyl-          und    Methylalkohol. Keine Fusion bis<B>2800.</B>



  Process for the preparation of the acetic acid ester of. 4-Laetylaminobenzene-1-arsic acid. The present invention relates to a process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsinic acid, which is characterized in that 4-aminobenzene-1-ai-sic acid is reacted with acetyllaic acid chloid.



  The new process product forms fine crystals that can be recrystallized from hot water and do not melt up to 280 ° C. It is sparingly soluble in water, slightly soluble in ethyl and methyl alcohol and is particularly effective in treating trypanosomal diseases.



  <I> Example: </I> 43 g of p-arsanilic acid are dissolved in 200 cm3 of water and <B> 150 </B> cm3 of 2N sodium hydroxide solution, the solution is cooled to 0 C and 32 g of acetyl milk acid chloride are added dropwise.

    During the reaction, 120 cm3 of 2N sodium hydroxide solution is kept at the initial alkalinity. Upon addition of hydrochloric acid until the Congo acid reaction occurs, the 4- (acetyllactyl) - aminobenzene-l-arsinic acid separates out in fine crystals, which are recrystallized from 800 cm 'of hot water. Yield 40 gr. Slightly soluble in water, easily soluble in ethyl and methyl alcohol. No merger until <B> 2800. </B>

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung des Essigsäure- esters der 4-Lactylaminobenzol-l-arsinsäure, dadurch gekennzeichnet, dass man 4-Amino- benzol-l-arsinsäure mit Acetylmilöhsäure- chlorid umsetzt. Das neue Verfahrensprodukt bildet feine Kristalle, die aus heissem Wasser umkristal- lisierbar sind und bis 280 C nicht schmelzen. PATENT CLAIM: Process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsinic acid, characterized in that 4-aminobenzene-1-arsic acid is reacted with acetylmiloic acid chloride. The new process product forms fine crystals that can be recrystallized from hot water and do not melt up to 280 ° C. Es ist schwer löslich in Wasser, leicht lös lich in Äthyl- und Methylalkohol und zeich net sich durch sehr gute Wirkung bei Try- panosomenkrankheiten aus. It is sparingly soluble in water, slightly soluble in ethyl and methyl alcohol and is characterized by its very good effect on trypanosomal diseases.
CH161242D 1930-07-19 1931-07-14 Process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsic acid. CH161242A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE161242X 1930-07-19
CH158386T 1931-07-14

Publications (1)

Publication Number Publication Date
CH161242A true CH161242A (en) 1933-04-15

Family

ID=25717103

Family Applications (1)

Application Number Title Priority Date Filing Date
CH161242D CH161242A (en) 1930-07-19 1931-07-14 Process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsic acid.

Country Status (1)

Country Link
CH (1) CH161242A (en)

Similar Documents

Publication Publication Date Title
CH161242A (en) Process for the preparation of the acetic acid ester of 4-lactylaminobenzene-1-arsic acid.
CH161243A (en) Process for the preparation of the crotonic acid ester of 4-lactylamino-2-methylbenzene-1-arsic acid.
CH161241A (en) Process for the preparation of the acetic acid ester of 3-glycolylamino-4-oxybenzene-1-arsic acid.
DE511466C (en) Process for the preparation of amino-substituted quinoline compounds
CH161240A (en) Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid.
DE466360C (en) Process for the preparation of salts of 1-methyl-4-isopropylbenzenesulfonic acids and their substitution products
CH161239A (en) Process for the preparation of the crotonic acid ester of 2-glycolylaminobenzene-1-arsic acid.
CH223030A (en) Process for the production of a condensation product.
CH194681A (en) Process for the preparation of sulfanilic acid-4-aminoanilide.
CH164093A (en) Process for the preparation of an asymmetric arsenobenzene compound.
CH125400A (en) Process for the preparation of a substituted quinoline carboxylic acid derivative.
CH151194A (en) Process for the preparation of the benzoic acid ester of 3-glycolylaminobenzene-1-arsic acid.
CH212595A (en) Process for the preparation of a quinoline compound containing a basic substituted amino group in the 4-position.
CH226010A (en) Process for the preparation of 4- (benzylideneaminomethyl) -benzenesulfonamide.
CH238089A (en) Process for the preparation of 4-amino-benzenesulfone-3&#39;-methyl-4&#39;-methylmercapto-benzamide.
CH168364A (en) Process for preparing an asymmetric arsenobenzene compound.
CH151193A (en) Process for the preparation of the crotonic acid ester of 4-glycolylamino-2-methylbenzene-1-arsic acid.
CH148701A (en) Process for the preparation of 3,9-diaminoacridine acetate.
CH191238A (en) Process for the preparation of 3-oxycarbazole-2-carboxylic acid.
CH180593A (en) Process for the preparation of 2-propoxy-5-acetylaminopyridine.
CH135746A (en) Process for the preparation of an o-oxybenzyl-amine-arsic acid.
CH227081A (en) Process for producing an azo compound.
CH143891A (en) Process for the preparation of an o-cyanarylrhodane compound.
CH119328A (en) Process for the preparation of an acyl compound of amino-3-chloro-4-oxybenzene-1-arsic acid.
CH162850A (en) Process for the preparation of O-methyldiiodochelidamic acid.