CH226010A - Process for the preparation of 4- (benzylideneaminomethyl) -benzenesulfonamide. - Google Patents
Process for the preparation of 4- (benzylideneaminomethyl) -benzenesulfonamide.Info
- Publication number
- CH226010A CH226010A CH226010DA CH226010A CH 226010 A CH226010 A CH 226010A CH 226010D A CH226010D A CH 226010DA CH 226010 A CH226010 A CH 226010A
- Authority
- CH
- Switzerland
- Prior art keywords
- benzylideneaminomethyl
- benzenesulfonamide
- preparation
- benzaldehyde
- aminomethyl
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Verfahren zur Darstellung von 4-(Benzylidenaminomethyl)-benzolsulfonamid. Gegenstand des vorliegenden Patentes ist ein Verfahren zur Herstellung des 4-(Ben- zylidenaminomethyl)-benzolsuHonamids, das dadurch gekennzeichnet ist, dass 4-Amino- methylbenzolsulfonamid mit Benzaldehyd umgesetzt wird.
Die Benzylidenverbindung bildet farb lose Kristalle vom Schmelzpunkt 157 . Die Kristalle sind in Wasser unlöslich, in ver dünnter kalter Natronlauge leicht löslich. Die Verbindung soll ass Arzneimittel sowie als Zwischenprodukt zur Herstellung von Arz- neimitteln Verwendung finden..
<I>Beispiel:</I> 18,6 g 4-Aminomethyl-benzolmlfonamid werden in 40 cm' Alkohol zum Kochen er hitzt. In die Lösung trägt man 10,6g Benz al.dehyd ein. Die Mischung reagiert unter Aufkochen. Man hält sie noch 30 Minuten im Sieden. Schon in der Hitze scheiden sich aus der Lösung (Kristalle ides 4-(Benzyliden- aminomethyl)-benzolsulfonamids ab.
Nach dem Abkühlen wird der Niederschlag abge saugt und aus verdünntem Alkohol um- kris@tallisiert.
Man erhält so die Benzylidenverbindung mit den bereits angegebenen Eigenschaften.
Process for the preparation of 4- (benzylideneaminomethyl) -benzenesulfonamide. The subject of the present patent is a process for the production of 4- (benzylideneaminomethyl) -benzenesulfonamide, which is characterized in that 4-aminomethylbenzenesulfonamide is reacted with benzaldehyde.
The benzylidene compound forms colorless crystals with a melting point of 157. The crystals are insoluble in water and easily soluble in dilute, cold sodium hydroxide solution. The compound is said to be used as pharmaceuticals and as an intermediate product in the manufacture of pharmaceuticals.
<I> Example: </I> 18.6 g of 4-aminomethyl-benzene-monamide are heated to boiling in 40 cm of alcohol. 10.6 g of benzaldehyde are added to the solution. The mixture reacts by boiling. Keep it simmering for another 30 minutes. Already in the heat of the solution (crystals of 4- (benzylidene-aminomethyl) -benzenesulphonamide separate.
After cooling, the precipitate is filtered off with suction and recrystallized from dilute alcohol.
This gives the benzylidene compound with the properties already indicated.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE241139X | 1939-11-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH226010A true CH226010A (en) | 1943-03-15 |
Family
ID=5909598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH226010D CH226010A (en) | 1939-11-24 | 1941-11-11 | Process for the preparation of 4- (benzylideneaminomethyl) -benzenesulfonamide. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH226010A (en) |
-
1941
- 1941-11-11 CH CH226010D patent/CH226010A/en unknown
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