CH161240A - Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid. - Google Patents

Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid.

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Publication number
CH161240A
CH161240A CH161240A CH161240A CH161240A CH 161240 A CH161240 A CH 161240A CH 161240 A CH161240 A CH 161240A CH 161240 A CH161240 A CH 161240A CH 161240 A CH161240 A CH 161240A
Authority
CH
Switzerland
Prior art keywords
acid
preparation
arsic
glycolylaminobenzene
acid ester
Prior art date
Application number
CH161240A
Other languages
German (de)
Inventor
Aktiengesellsc Farbenindustrie
Original Assignee
Ig Farbenindustrie Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ig Farbenindustrie Ag filed Critical Ig Farbenindustrie Ag
Publication of CH161240A publication Critical patent/CH161240A/en

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Description

  

  Verfahren zur Darstellung des     Benzoesäureesters    der     2-Glykolylaminobenzol-l-          arsinsäure.       Gegenstand der vorliegenden Erfindung  ist ein Verfahren zur Darstellung des     Benzoe-          säureesters    der     2-(llykolylaminöbenzol-l-arsiu-          säure,    welches dadurch gekennzeichnet ist,  dass man     2-Aminobenzol-1-arsinsäure    mit       Berizoylglykolsäui-eehlorid    umsetzt:  Das neue Verfahrensprodukt bildet aus  Wasser     umkristallisierbare    Nadeln;

   F.183 bis  185   C, und zeichnet sich bei geringer     Toxi-          zität    durch sehr gute Wirkung speziell bei       Trypanosomenkrankheiten    aus.  



  <I>Beispiel:</I>  21,7     gr        2-Aininobenzol-l-arsirisäure    werden  in 200     cms        n-Natronlauge    gelöst, die     Lösung     auf 0   C abgekühlt und 22     gr        Benzoylglykol-          säurechlorid        zutropfen    gelassen. Während der  Umsetzung hält man mit etwa GO     cm3        2-n-          Natronlauge    alkalisch. Auf Zugabe von Salz  säure scheidet sich die 2-(Benzoylglykolyl)-         aminobenzol-l-arsinsäure    ab, die aus Wasser  umkristallisiert in feinen Nadeln erhalten  wird.

   Ausbeute 25     gr    Nadeln, aus Wasser       umkristallisierbar,    F. 183-185   C.



  Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-l-arsic acid. The present invention relates to a process for the preparation of the benzoic acid ester of 2- (llycolylaminobenzene-1-arsic acid, which is characterized in that 2-aminobenzene-1-arsic acid is reacted with berizoylglycolic acid chloride: The new process product forms Water recrystallizable needles;

   F.183 to 185 C, and is characterized by its low toxicity and its very good effect, especially on trypanosomal diseases.



  <I> Example: </I> 21.7 g of 2-aminobenzene-1-arsiric acid are dissolved in 200 cms of n-sodium hydroxide solution, the solution is cooled to 0 ° C. and 22 g of benzoylglycolic acid chloride are added dropwise. During the reaction, about 100 cm3 of 2N sodium hydroxide solution is kept alkaline. Upon addition of hydrochloric acid, the 2- (benzoylglycolyl) - aminobenzene-l-arsic acid separates out, which is obtained in fine needles recrystallized from water.

   Yield 25 gr needles, recrystallizable from water, F. 183-185 C.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung des Benzoe- säureesters der 2-Cxlykolylaminobenzol-l-ar-siri- säure, dadurch gekennzeichnet, dass man 2- Aminobenzol-l-ai-sinsäure mit Benzoylglykolyi- säurechlorid umsetzt. Das neue Verfahrensprodukt bildet aus Wasser umkristallisierbare Nadeln, F. 183 bis 185 C, und zeichnet sich bei geringer Toxi- zität durch sehr gute Wirkung speziell bei Trypanosomenkrankheiten aus. PATENT CLAIM: Process for the preparation of the benzoic acid ester of 2-Cxlykolylaminobenzol-l-ar-siric acid, characterized in that 2-aminobenzene-l-ai-sic acid is reacted with benzoylglycolic acid chloride. The new process product forms needles that can be recrystallized from water, at a temperature of 183 to 185 C, and is characterized by its low toxicity and very good effect, especially in the case of trypanosomal diseases.
CH161240A 1930-07-19 1931-07-14 Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid. CH161240A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE158386X 1930-07-19

Publications (1)

Publication Number Publication Date
CH161240A true CH161240A (en) 1933-04-15

Family

ID=5679570

Family Applications (2)

Application Number Title Priority Date Filing Date
CH161240A CH161240A (en) 1930-07-19 1931-07-14 Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid.
CH158386D CH158386A (en) 1930-07-19 1931-07-14 Process for the preparation of the acetic acid ester of 2-glycolylaminobenzene-1-arsic acid.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH158386D CH158386A (en) 1930-07-19 1931-07-14 Process for the preparation of the acetic acid ester of 2-glycolylaminobenzene-1-arsic acid.

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CH (2) CH161240A (en)

Also Published As

Publication number Publication date
CH158386A (en) 1932-11-15

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