CH161240A - Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid. - Google Patents
Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid.Info
- Publication number
- CH161240A CH161240A CH161240A CH161240A CH161240A CH 161240 A CH161240 A CH 161240A CH 161240 A CH161240 A CH 161240A CH 161240 A CH161240 A CH 161240A CH 161240 A CH161240 A CH 161240A
- Authority
- CH
- Switzerland
- Prior art keywords
- acid
- preparation
- arsic
- glycolylaminobenzene
- acid ester
- Prior art date
Links
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung des Benzoesäureesters der 2-Glykolylaminobenzol-l- arsinsäure. Gegenstand der vorliegenden Erfindung ist ein Verfahren zur Darstellung des Benzoe- säureesters der 2-(llykolylaminöbenzol-l-arsiu- säure, welches dadurch gekennzeichnet ist, dass man 2-Aminobenzol-1-arsinsäure mit Berizoylglykolsäui-eehlorid umsetzt: Das neue Verfahrensprodukt bildet aus Wasser umkristallisierbare Nadeln;
F.183 bis 185 C, und zeichnet sich bei geringer Toxi- zität durch sehr gute Wirkung speziell bei Trypanosomenkrankheiten aus.
<I>Beispiel:</I> 21,7 gr 2-Aininobenzol-l-arsirisäure werden in 200 cms n-Natronlauge gelöst, die Lösung auf 0 C abgekühlt und 22 gr Benzoylglykol- säurechlorid zutropfen gelassen. Während der Umsetzung hält man mit etwa GO cm3 2-n- Natronlauge alkalisch. Auf Zugabe von Salz säure scheidet sich die 2-(Benzoylglykolyl)- aminobenzol-l-arsinsäure ab, die aus Wasser umkristallisiert in feinen Nadeln erhalten wird.
Ausbeute 25 gr Nadeln, aus Wasser umkristallisierbar, F. 183-185 C.
Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-l-arsic acid. The present invention relates to a process for the preparation of the benzoic acid ester of 2- (llycolylaminobenzene-1-arsic acid, which is characterized in that 2-aminobenzene-1-arsic acid is reacted with berizoylglycolic acid chloride: The new process product forms Water recrystallizable needles;
F.183 to 185 C, and is characterized by its low toxicity and its very good effect, especially on trypanosomal diseases.
<I> Example: </I> 21.7 g of 2-aminobenzene-1-arsiric acid are dissolved in 200 cms of n-sodium hydroxide solution, the solution is cooled to 0 ° C. and 22 g of benzoylglycolic acid chloride are added dropwise. During the reaction, about 100 cm3 of 2N sodium hydroxide solution is kept alkaline. Upon addition of hydrochloric acid, the 2- (benzoylglycolyl) - aminobenzene-l-arsic acid separates out, which is obtained in fine needles recrystallized from water.
Yield 25 gr needles, recrystallizable from water, F. 183-185 C.
Claims (1)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE158386X | 1930-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CH161240A true CH161240A (en) | 1933-04-15 |
Family
ID=5679570
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH158386D CH158386A (en) | 1930-07-19 | 1931-07-14 | Process for the preparation of the acetic acid ester of 2-glycolylaminobenzene-1-arsic acid. |
CH161240A CH161240A (en) | 1930-07-19 | 1931-07-14 | Process for the preparation of the benzoic acid ester of 2-glycolylaminobenzene-1-arsic acid. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CH158386D CH158386A (en) | 1930-07-19 | 1931-07-14 | Process for the preparation of the acetic acid ester of 2-glycolylaminobenzene-1-arsic acid. |
Country Status (1)
Country | Link |
---|---|
CH (2) | CH158386A (en) |
-
1931
- 1931-07-14 CH CH158386D patent/CH158386A/en unknown
- 1931-07-14 CH CH161240A patent/CH161240A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CH158386A (en) | 1932-11-15 |
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