CA950828A - Polylactide-drug mixtures for topical application - Google Patents

Polylactide-drug mixtures for topical application

Info

Publication number
CA950828A
CA950828A CA134,263,A CA134263A CA950828A CA 950828 A CA950828 A CA 950828A CA 134263 A CA134263 A CA 134263A CA 950828 A CA950828 A CA 950828A
Authority
CA
Canada
Prior art keywords
polylactide
topical application
drug mixtures
drug
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA134,263,A
Other languages
English (en)
Other versions
CA134263S (en
Inventor
Richard M. Scribner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of CA950828A publication Critical patent/CA950828A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
CA134,263,A 1971-02-23 1972-02-08 Polylactide-drug mixtures for topical application Expired CA950828A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11808171A 1971-02-23 1971-02-23

Publications (1)

Publication Number Publication Date
CA950828A true CA950828A (en) 1974-07-09

Family

ID=22376416

Family Applications (1)

Application Number Title Priority Date Filing Date
CA134,263,A Expired CA950828A (en) 1971-02-23 1972-02-08 Polylactide-drug mixtures for topical application

Country Status (5)

Country Link
US (1) US3755558A (OSRAM)
CA (1) CA950828A (OSRAM)
DE (1) DE2207635A1 (OSRAM)
FR (1) FR2126270B1 (OSRAM)
GB (1) GB1351409A (OSRAM)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962414A (en) * 1972-04-27 1976-06-08 Alza Corporation Structured bioerodible drug delivery device
US4001388A (en) * 1973-06-14 1977-01-04 Alza Corporation Ophthalmological bioerodible drug dispensing formulation
US3914402A (en) * 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
AR205997A1 (es) * 1973-11-21 1976-06-23 American Cyanamid Co Resina de poliester normalmente solida biodegradable e hidrolizable
US3960152A (en) * 1974-01-21 1976-06-01 American Cyanamid Company Surgical sutures of unsymmetrically substituted 1,4-dioxane-2,5-diones
US4076798A (en) * 1975-05-29 1978-02-28 American Cyanamid Company High molecular weight polyester resin, the method of making the same and the use thereof as a pharmaceutical composition
US4011312A (en) * 1975-06-25 1977-03-08 American Home Products Corporation Prolonged release drug form for the treatment of bovine mastitis
GB1556710A (en) * 1975-09-12 1979-11-28 Anic Spa Method of occluding substances in structures and products obtained thereby
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
US4328204A (en) * 1977-03-02 1982-05-04 Ethicon, Inc. Absorbable polymer-drug compounds and method for making same
WO1978000011A1 (fr) * 1977-06-07 1978-12-21 Garching Instrumente Forme d'implant medicamenteux et procede de preparation
US4186189A (en) * 1977-09-28 1980-01-29 Ethicon, Inc. Absorbable pharmaceutical compositions based on poly(alkylene oxalates)
US4585651A (en) * 1978-10-17 1986-04-29 Stolle Research & Development Corporation Active/passive immunization of the internal female reproductive organs
US4732763A (en) * 1978-10-17 1988-03-22 Stolle Research And Development Corporation Active/passive immunization of the internal female reproductive organs
AU539230B2 (en) * 1979-09-12 1984-09-20 Eli Lilly And Company Parasitic formulations and method
US4293539A (en) * 1979-09-12 1981-10-06 Eli Lilly And Company Controlled release formulations and method of treatment
AU534665B2 (en) * 1979-09-12 1984-02-09 Eli Lilly And Company Method
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
DE3218150C2 (de) * 1982-05-14 1986-09-25 Akzo Gmbh, 5600 Wuppertal Wirkstoff enthaltender Körper für die Langzeitabgabe sowie Verfahren zu dessen Herstellung
US5248700A (en) * 1982-05-14 1993-09-28 Akzo Nv Active agent containing solid structures for prolonged release of active agents
AT382076B (de) * 1982-10-15 1987-01-12 Chemie Linz Ag Verfahren zur herstellung von presslingen mit retardierter wirkstofffreisetzung
JPS6045522B2 (ja) * 1982-12-08 1985-10-09 憲司 中村 化粧用具
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
IN166447B (OSRAM) * 1985-11-27 1990-05-12 Ethicon Inc
JPH0798755B2 (ja) * 1985-11-27 1995-10-25 エチコン・インコ−ポレ−テツド 局所的投与により術後の癒着形成を抑制するための組成物
US4889722A (en) * 1985-12-16 1989-12-26 Ethicon, Inc. Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
KR870005646A (ko) * 1985-12-16 1987-07-06 로버트 엘. 미니어 수술후 유착형성 억제방법
JPS62228021A (ja) * 1986-02-24 1987-10-06 エチコン・インコ−ポレ−テツド 手術後の癒着の形成を防止または減少する方法
DE3620685A1 (de) * 1986-06-20 1987-12-23 Henkel Kgaa Neue mittel zur abdeckung unverletzter und/oder verletzter bereiche menschlicher oder tierischer haut
US5985354A (en) 1995-06-07 1999-11-16 Brown University Research Foundation Preparation of multiwall polymeric microcapsules from hydrophilic polymers
DE3734223A1 (de) * 1987-10-09 1989-04-20 Boehringer Ingelheim Kg Implantierbares, biologisch abbaubares wirkstofffreigabesystem
US5444113A (en) * 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5252642A (en) * 1989-03-01 1993-10-12 Biopak Technology, Ltd. Degradable impact modified polyactic acid
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US5216050A (en) * 1988-08-08 1993-06-01 Biopak Technology, Ltd. Blends of polyactic acid
US5632727A (en) * 1988-10-03 1997-05-27 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5725491A (en) * 1988-10-03 1998-03-10 Atrix Laboratories, Inc. Method of forming a biodegradable film dressing on tissue
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5633002A (en) * 1988-10-04 1997-05-27 Boehringer Ingelheim Gmbh Implantable, biodegradable system for releasing active substance
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
USRE37950E1 (en) 1990-04-24 2002-12-31 Atrix Laboratories Biogradable in-situ forming implants and methods of producing the same
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
DE4112489C2 (de) * 1991-04-17 1994-06-09 Christian Dr Med Juergens Verwendung von resorbierbaren, physiologisch unbedenklichen Copolymeren für die topische Behandlung menschlicher oder tierischer Haut
EP0509203A3 (en) 1991-04-17 1993-04-14 Christian Dr. Med. Juergens Resorbable, physiologically acceptable copolymers and their use
DE4229924C2 (de) * 1991-04-17 1995-12-07 Juergens Christian Dr Med Verwendung von resorbierbaren Lactidcopolymeren
TW247878B (OSRAM) * 1991-07-02 1995-05-21 Takeda Pharm Industry Co Ltd
US6005067A (en) 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
EP0560014A1 (en) * 1992-03-12 1993-09-15 Atrix Laboratories, Inc. Biodegradable film dressing and method for its formation
US5576418A (en) * 1992-06-29 1996-11-19 Jurgens; Christian Resorbable biocompatible copolymers and their use
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US5618563A (en) * 1992-09-10 1997-04-08 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
JP3447289B2 (ja) * 1992-10-02 2003-09-16 カーギル， インコーポレイテッド 溶融安定性ラクチドポリマー繊維及びその製造方法
BR9305658A (pt) * 1992-10-02 1996-11-26 Cargill Inc Papel tendo um polímero de lactideo estável em fusao e processo para sua produçao
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US5714573A (en) * 1995-01-19 1998-02-03 Cargill, Incorporated Impact modified melt-stable lactide polymer compositions and processes for manufacture thereof
US5618850A (en) * 1995-03-09 1997-04-08 Focal, Inc. Hydroxy-acid cosmetics
US5722950A (en) * 1995-06-07 1998-03-03 Atrix Laboratories, Inc. Method for remote delivery of an aerosolized liquid
CN1156961A (zh) 1995-06-09 1997-08-13 欧罗赛铁克股份有限公司 产生长效局部麻醉的制剂和方法
DE19600095A1 (de) 1996-01-03 1997-07-10 Christian Dr Med Juergens Verwendung von Lactidpolymeren zur Adhäsionsprophylaxe
AU733867B2 (en) 1996-06-24 2001-05-31 Euro-Celtique S.A. Methods for providing safe local anesthesia
US5756651A (en) * 1996-07-17 1998-05-26 Chronopol, Inc. Impact modified polylactide
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5955097A (en) * 1996-10-18 1999-09-21 Virotex Corporation Pharmaceutical preparation applicable to mucosal surfaces and body tissues
US5858531A (en) * 1996-10-24 1999-01-12 Bio Syntech Method for preparation of polymer microparticles free of organic solvent traces
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
WO1999001114A1 (en) * 1997-07-02 1999-01-14 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
US7128927B1 (en) 1998-04-14 2006-10-31 Qlt Usa, Inc. Emulsions for in-situ delivery systems
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
ES2230780T3 (es) 1999-08-18 2005-05-01 Christian Dr. Med. Jurgens Copolilactidos resorbibles y su empleo.
US8226598B2 (en) * 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
WO2001036000A1 (en) * 1999-11-15 2001-05-25 Bio Syntech Canada, Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
US20020082220A1 (en) 2000-06-29 2002-06-27 Hoemann Caroline D. Composition and method for the repair and regeneration of cartilage and other tissues
PT1693054T (pt) * 2000-08-07 2016-07-07 Takeda Pharmaceuticals Co Polímero de ácido láctico e processo para a sua produção
CA2429168C (en) * 2000-11-15 2010-06-08 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
EP1363602A4 (en) * 2001-01-25 2006-01-11 Euro Celtique Sa LOCAL ANESTHESIA, AND METHOD OF USE
EP1400233A4 (en) * 2001-06-12 2005-02-09 Trial Corp COSMETIC PRODUCT
TWI332407B (en) * 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7910641B2 (en) 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US7264822B2 (en) * 2002-04-03 2007-09-04 Poly-Med, Inc. Conjugated drug-polymer coated stent
US8414874B2 (en) * 2002-04-24 2013-04-09 Poly-Med, Inc. Multifaceted endovascular stent coating for preventing restenosis
EP1660039B1 (en) 2003-07-18 2016-09-28 Oakwood Laboratories L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
WO2007075422A2 (en) * 2005-12-27 2007-07-05 Monosol Rx, Llc Ph modulated films for delivery of actives
US8921326B2 (en) 2006-12-18 2014-12-30 Takeda Pharmaceutical Company Limited Sustained-release composition and method for producing the same
ES2581837T3 (es) * 2010-07-26 2016-09-07 Université De Genève Composiciones que comprenden polímeros preparados a partir de ácidos 2-hidroxi alquil
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
DE102013209897A1 (de) * 2013-05-28 2014-12-04 Henkel Ag & Co. Kgaa Kosmetisches Hautpflegemittel
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
KR20190005199A (ko) 2016-05-05 2019-01-15 어퀘스티브 테라퓨틱스, 아이엔씨. 강화된 전달 에프네프린 조성물
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
IT201700058311A1 (it) * 2017-05-29 2018-11-29 Bio Lo Ga Srl Formulazione a base di vitamina E o di un suo estere per il trattamento di biofilm batterici e fungini
US20210196648A1 (en) * 2019-12-31 2021-07-01 Industrial Technology Research Institute Drug-containing multilayer film and method for forming the same
DE102020215294A1 (de) * 2020-12-03 2022-06-23 Polymedics Innovations Gmbh Pflasterzubereitung, Polymerfilm, Sprühpflastersprühvorrichtung, Verfahren zur Herstellung eines Polymerfaservlieses, Polymerfaservlies und Verwendungen der Pflasterzubereitung
US12465564B2 (en) 2021-10-25 2025-11-11 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment

Also Published As

Publication number Publication date
DE2207635A1 (de) 1972-08-31
US3755558A (en) 1973-08-28
FR2126270B1 (OSRAM) 1975-11-28
FR2126270A1 (OSRAM) 1972-10-06
GB1351409A (en) 1974-05-01

Similar Documents

Publication Publication Date Title
CA950828A (en) Polylactide-drug mixtures for topical application
CA1017336A (en) Divinyl-diphenyl compounds
CA946282A (en) Topical ointment base
AU459132B2 (en) Etrachlorophthalide compounds
AU466025B2 (en) Aminohalopyridyloxy compounds
CA1026346A (en) Triazolyphosphorus compounds
CA1006163A (en) Arylaminopyridine compounds
CA981269A (en) 3-carbamoyl-4-phenyl-quinoline compounds
CA1024203A (en) Workbench
CA994767A (en) Triazolothienodiazepine compounds
CA994357A (en) Bis-stilbene compounds
CA977345A (en) Perfluoroalkyl-phosphorus compounds
CA1019871A (en) Arc- and track - resistant polyepoxide - polysiloxane compounds
CA983946A (en) Disilyl-containing compounds
CA1001641A (en) Polyhalobenzylic disulfooxonium compounds
AU415157B2 (en) Depilatory composition
CA865773A (en) Alkylenebisdithiocarbamate complex compounds
CA870626A (en) 1-substituted-2-mercapto-5-methylimidazole compounds
CA879704A (en) Triazinylaminocoumarin compounds
CA903236A (en) Indole-3-methylsulfoximinolower-alkyl compounds
CA903237A (en) Indole-3-n-acylacetamide compounds
CA867369A (en) 1-arylamino-4-arylsulfonamidoanthraquinone compounds
CA861533A (en) N-propargyl-pyridinium compounds
CA867752A (en) Azoacyl compounds
CA866216A (en) Gem-difluoramino compounds