CA941769A - Process for the manufacture of penicillin acylase - Google Patents

Process for the manufacture of penicillin acylase

Info

Publication number
CA941769A
CA941769A CA041,889A CA41889A CA941769A CA 941769 A CA941769 A CA 941769A CA 41889 A CA41889 A CA 41889A CA 941769 A CA941769 A CA 941769A
Authority
CA
Canada
Prior art keywords
manufacture
penicillin acylase
acylase
penicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA041,889A
Other languages
English (en)
Other versions
CA41889S (en
Inventor
Lars S. Nathorst-Westfelt
Bertil A. Ekstrom
Per S. Delin
Karl H. Thelin
Berndt O. H. Sjoberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB57373/68A external-priority patent/GB1261711A/en
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of CA941769A publication Critical patent/CA941769A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Handcart (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA041,889A 1968-02-15 1969-02-04 Process for the manufacture of penicillin acylase Expired CA941769A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB754468 1968-02-15
GB57373/68A GB1261711A (en) 1968-02-15 1968-12-03 Process for producing a penicillin acylose composition

Publications (1)

Publication Number Publication Date
CA941769A true CA941769A (en) 1974-02-12

Family

ID=26241501

Family Applications (1)

Application Number Title Priority Date Filing Date
CA041,889A Expired CA941769A (en) 1968-02-15 1969-02-04 Process for the manufacture of penicillin acylase

Country Status (17)

Country Link
JP (2) JPS4833386B1 (de)
AT (2) AT297218B (de)
BE (1) BE727506A (de)
CA (1) CA941769A (de)
CH (2) CH523320A (de)
CS (1) CS155970B2 (de)
DE (4) DE1907365A1 (de)
DK (1) DK128421B (de)
ES (4) ES363592A1 (de)
FI (1) FI47109C (de)
FR (2) FR2001977A1 (de)
IE (1) IE32962B1 (de)
IT (1) IT1061759B (de)
NL (1) NL158547B (de)
NO (3) NO131388C (de)
SE (3) SE352643B (de)
SU (1) SU404195A3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1357317A (en) * 1970-08-27 1974-06-19 Beecham Group Ltd Enzymes
IL39158A (en) * 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
BE791748A (fr) * 1971-11-23 1973-05-22 Bayer Ag Procede de production d'acide 6-aminopenicillanique par ruptureenzymatique de penicillines
JPS5420193A (en) * 1977-07-12 1979-02-15 Tanabe Seiyaku Co Ltd Immobilized aminoacylase and its preparation
GB9718740D0 (en) 1997-09-05 1997-11-12 Advanced Phytonics Ltd Improvements in or relating to the preparation of a compound
DE10123048A1 (de) * 2001-05-11 2002-11-21 Bermatingen Maschf Messer für Kreiselmulchgeräte

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB877898A (en) * 1956-12-06 1961-09-20 Apv Co Ltd A new or improved method of liberating enzymes
GB1118566A (en) * 1964-11-25 1968-07-03 Beecham Group Ltd Production of 6-aminopenicillanic acid

Also Published As

Publication number Publication date
DE1966427C3 (de) 1980-03-13
ES384027A1 (es) 1973-06-01
AT297218B (de) 1972-03-10
NO131386C (de) 1975-05-21
ES384026A1 (es) 1973-04-16
FR2081316B1 (de) 1974-08-30
NO131386B (de) 1975-02-10
DE1966427B2 (de) 1979-07-12
NO131388B (de) 1975-02-10
NO131387B (de) 1975-02-10
SE352643B (de) 1973-01-08
IT1061759B (it) 1983-04-30
DE1966428A1 (de) 1972-09-14
NL6902045A (de) 1969-08-19
IE32962B1 (en) 1974-02-06
IE32962L (en) 1969-08-15
FR2001977B1 (de) 1974-08-30
FI47109C (fi) 1973-09-10
DE1907365A1 (de) 1969-09-11
AT300198B (de) 1972-07-10
CH523320A (de) 1972-05-31
SE400291B (sv) 1978-03-20
SE382990B (sv) 1976-02-23
JPS5622278B1 (de) 1981-05-23
BE727506A (de) 1969-07-01
FR2001977A1 (en) 1969-10-03
ES384025A1 (es) 1973-04-16
SU404195A3 (de) 1973-10-26
CH538540A (de) 1973-08-15
CS155970B2 (de) 1974-06-24
DK128421B (da) 1974-04-29
DE1933301A1 (de) 1970-06-25
DE1966428B2 (de) 1977-07-21
DE1966427A1 (de) 1972-08-24
NL158547B (nl) 1978-11-15
FR2081316A1 (de) 1971-12-03
DE1966428C3 (de) 1978-03-02
NO131388C (de) 1975-05-21
ES363592A1 (es) 1970-12-16
FI47109B (de) 1973-05-31
NO131387C (de) 1975-05-21
JPS4833386B1 (de) 1973-10-13

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