CA3214529A1 - Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof - Google Patents
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereofInfo
- Publication number
- CA3214529A1 CA3214529A1 CA3214529A CA3214529A CA3214529A1 CA 3214529 A1 CA3214529 A1 CA 3214529A1 CA 3214529 A CA3214529 A CA 3214529A CA 3214529 A CA3214529 A CA 3214529A CA 3214529 A1 CA3214529 A1 CA 3214529A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- amino acid
- acid sequence
- sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361882377P | 2013-09-25 | 2013-09-25 | |
| US61/882,377 | 2013-09-25 | ||
| US201461971332P | 2014-03-27 | 2014-03-27 | |
| US61/971,332 | 2014-03-27 | ||
| CA2925106A CA2925106C (en) | 2013-09-25 | 2014-09-25 | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2925106A Division CA2925106C (en) | 2013-09-25 | 2014-09-25 | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3214529A1 true CA3214529A1 (en) | 2015-04-02 |
Family
ID=51691175
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3214529A Pending CA3214529A1 (en) | 2013-09-25 | 2014-09-25 | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
| CA2925106A Active CA2925106C (en) | 2013-09-25 | 2014-09-25 | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2925106A Active CA2925106C (en) | 2013-09-25 | 2014-09-25 | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20150087810A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3049111A2 (cg-RX-API-DMAC7.html) |
| JP (5) | JP6915987B2 (cg-RX-API-DMAC7.html) |
| KR (3) | KR20250051130A (cg-RX-API-DMAC7.html) |
| CN (3) | CN106163556B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2014324884B2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA3214529A1 (cg-RX-API-DMAC7.html) |
| IL (3) | IL322893A (cg-RX-API-DMAC7.html) |
| MX (2) | MX379106B (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ756892A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2715232C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015048329A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (92)
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| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| KR102182485B1 (ko) | 2013-05-28 | 2020-11-25 | 카오슝 메디칼 유니버시티 | 단백질 약물의 불활성화를 위한 항체 로커 |
| KR20250051130A (ko) | 2013-09-25 | 2025-04-16 | 싸이톰스 테라퓨틱스, 인크. | 매트릭스 메탈로프로테이나제 기질 및 다른 절단성 모이어티 및 이의 사용 방법 |
| JP6835586B2 (ja) | 2014-01-31 | 2021-02-24 | シトムクス セラピューティクス，インコーポレイティド | マトリプターゼ及びｕ‐プラスミノーゲン活性化因子の基質及び他の切断可能部分、並びにその使用方法 |
| HUE054526T2 (hu) | 2014-10-29 | 2021-09-28 | Bicyclerd Ltd | MT1-MMP-ra specifikus biciklusos peptid ligandumok |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| IL255697B2 (en) | 2015-05-18 | 2023-11-01 | Tcr2 Therapeutics Inc | Compositions and methods for TCR programming using fusion proteins |
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