CA3207210A1 - Novel method for producing antibody-immunostimulator conjugate - Google Patents

Novel method for producing antibody-immunostimulator conjugate Download PDF

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Publication number
CA3207210A1
CA3207210A1 CA3207210A CA3207210A CA3207210A1 CA 3207210 A1 CA3207210 A1 CA 3207210A1 CA 3207210 A CA3207210 A CA 3207210A CA 3207210 A CA3207210 A CA 3207210A CA 3207210 A1 CA3207210 A1 CA 3207210A1
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Prior art keywords
formula
compound
antibody
compound represented
tert
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CA3207210A
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English (en)
French (fr)
Inventor
Tomokazu OGURA
Takeshi Nakaya
Hidekazu Inoue
Narumi Abe
Yuzo Abe
Tatsuya Nakamura
Yuko Yamamoto
Kohei Sakanishi
Tatsuhiro Sakamoto
Satoshi Nakane
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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Publication of CA3207210A1 publication Critical patent/CA3207210A1/en
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
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