CA3184495A1 - Anti-hbv antibodies and methods of use - Google Patents

Anti-hbv antibodies and methods of use

Info

Publication number
CA3184495A1
CA3184495A1 CA3184495A CA3184495A CA3184495A1 CA 3184495 A1 CA3184495 A1 CA 3184495A1 CA 3184495 A CA3184495 A CA 3184495A CA 3184495 A CA3184495 A CA 3184495A CA 3184495 A1 CA3184495 A1 CA 3184495A1
Authority
CA
Canada
Prior art keywords
seq
sequence
amino acid
antibody
cdr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3184495A
Other languages
English (en)
French (fr)
Inventor
Maryline BOURGINE
Maxime BERETTA
Hugo MOUQUET
Verena HEHLE
Stanislas Pol
Helene Strick-Marchand
Malika AIT-GOUGHOULTE
Nadege Pelletier
Jens Fischer
Guy Georges
Tilman Schlothauer
Erwin Van Puijenbroek
Wouter DRIESSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Institut Pasteur
Original Assignee
F Hoffmann La Roche AG
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Institut Pasteur filed Critical F Hoffmann La Roche AG
Publication of CA3184495A1 publication Critical patent/CA3184495A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—DNA viruses
    • C07K16/082—Hepadnaviridae (F), e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3184495A 2020-06-08 2021-06-08 Anti-hbv antibodies and methods of use Pending CA3184495A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20305612.2 2020-06-08
EP20305612 2020-06-08
PCT/EP2021/065260 WO2021249990A2 (en) 2020-06-08 2021-06-08 Anti-hbv antibodies and methods of use

Publications (1)

Publication Number Publication Date
CA3184495A1 true CA3184495A1 (en) 2021-12-16

Family

ID=71614786

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3184495A Pending CA3184495A1 (en) 2020-06-08 2021-06-08 Anti-hbv antibodies and methods of use

Country Status (17)

Country Link
US (1) US20230340081A1 (enExample)
EP (1) EP4161644A2 (enExample)
JP (1) JP7874062B2 (enExample)
KR (1) KR20230020975A (enExample)
CN (1) CN115697489A (enExample)
AR (1) AR122569A1 (enExample)
AU (1) AU2021288916A1 (enExample)
BR (1) BR112022024996A2 (enExample)
CA (1) CA3184495A1 (enExample)
CL (1) CL2022003288A1 (enExample)
CO (1) CO2022019225A2 (enExample)
CR (1) CR20220659A (enExample)
IL (1) IL298302A (enExample)
MX (1) MX2022015206A (enExample)
PE (1) PE20240080A1 (enExample)
TW (1) TWI904172B (enExample)
WO (1) WO2021249990A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024089366A (ja) * 2022-12-21 2024-07-03 国立大学法人広島大学 抗ＨＢｓ抗体およびその用途
WO2025183628A1 (en) * 2024-03-01 2025-09-04 Scg Cell Therapy Pte. Ltd. Anti-hbv antibodies or fragments thereof and methods of their use
WO2025224166A1 (en) 2024-04-23 2025-10-30 F. Hoffmann-La Roche Ag Anti-drug antibody assays

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WO2021249990A2 (en) 2021-12-16
EP4161644A2 (en) 2023-04-12
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AU2021288916A1 (en) 2022-11-24
TW202204396A (zh) 2022-02-01
CO2022019225A2 (es) 2023-03-17
MX2022015206A (es) 2023-01-05
JP2023527918A (ja) 2023-06-30
WO2021249990A3 (en) 2022-02-10
KR20230020975A (ko) 2023-02-13
CR20220659A (es) 2023-08-21
BR112022024996A2 (pt) 2022-12-27
CN115697489A (zh) 2023-02-03
TWI904172B (zh) 2025-11-11
US20230340081A1 (en) 2023-10-26
JP7874062B2 (ja) 2026-06-15
CL2022003288A1 (es) 2023-05-12
IL298302A (en) 2023-01-01

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