CA3138763A1 - Media and fermentation methods for producing polysaccharides in bacterial cell culture - Google Patents

Media and fermentation methods for producing polysaccharides in bacterial cell culture Download PDF

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Publication number
CA3138763A1
CA3138763A1 CA3138763A CA3138763A CA3138763A1 CA 3138763 A1 CA3138763 A1 CA 3138763A1 CA 3138763 A CA3138763 A CA 3138763A CA 3138763 A CA3138763 A CA 3138763A CA 3138763 A1 CA3138763 A1 CA 3138763A1
Authority
CA
Canada
Prior art keywords
medium
polysaccharide
concentration
perfusion
cultivation method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3138763A
Other languages
English (en)
French (fr)
Inventor
Sunil Gururao DESAI
Michael Allen Hanson
Jonathan Patrick KINROSS
Daniel R. Lasko
Scott Ellis LOMBERK
Jason Arnold Lotvin
Sujata Kaushikbhai PATEL-BROWN
Weiqiang SUN
Peter Anthony TOMASELLO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA3138763A1 publication Critical patent/CA3138763A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3138763A 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture Pending CA3138763A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562256347P 2015-11-17 2015-11-17
US62/256,347 2015-11-17
US201662413051P 2016-10-26 2016-10-26
US62/413,051 2016-10-26
CA3005308A CA3005308C (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3005308A Division CA3005308C (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

Publications (1)

Publication Number Publication Date
CA3138763A1 true CA3138763A1 (en) 2017-05-26

Family

ID=57394621

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3138763A Pending CA3138763A1 (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture
CA3005308A Active CA3005308C (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3005308A Active CA3005308C (en) 2015-11-17 2016-11-10 Media and fermentation methods for producing polysaccharides in bacterial cell culture

Country Status (13)

Country Link
US (3) US10947494B2 (https=)
EP (1) EP3377613A1 (https=)
JP (3) JP7311966B2 (https=)
KR (1) KR102069988B1 (https=)
CN (1) CN108473945A (https=)
AU (1) AU2016357567B2 (https=)
BR (1) BR112018008864A8 (https=)
CA (2) CA3138763A1 (https=)
HK (1) HK1259103A1 (https=)
IL (2) IL319202A (https=)
MX (2) MX385736B (https=)
RU (2) RU2761633C2 (https=)
WO (1) WO2017085602A1 (https=)

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BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
KR102906912B1 (ko) 2016-09-02 2026-01-05 사노피 파스퇴르 인크 네이세리아 메닌기티디스 백신
CN110225764A (zh) 2017-01-31 2019-09-10 默沙东公司 制备多糖-蛋白缀合物的方法
CA3050120A1 (en) 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates
CN111065387B (zh) 2017-09-07 2023-08-25 默沙东有限责任公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
WO2019050813A1 (en) 2017-09-07 2019-03-14 Merck Sharp & Dohme Corp. ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER
TWI725359B (zh) 2017-12-06 2021-04-21 美商默沙東藥廠 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法
EP3787673A4 (en) 2018-04-30 2022-04-27 Merck Sharp & Dohme Corp. Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates
JP7397000B2 (ja) 2018-04-30 2023-12-12 メルク・シャープ・アンド・ドーム・エルエルシー 凍結乾燥変異ジフテリア毒素のジメチルスルホキシド中均一溶液を提供する方法
US12144855B2 (en) 2018-04-30 2024-11-19 Merck Sharp & Dohme Llc Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres
KR102609289B1 (ko) * 2018-12-06 2023-12-01 인벤트프라이즈 인크. 비-동물성 배지에서의 박테리아 증식
WO2020123524A1 (en) * 2018-12-11 2020-06-18 Erbi Biosystems, Inc. Methods of manufacturing cell based products using small volume perfusion processes
GEAP202415690A (en) 2018-12-19 2024-01-10 Merck Sharp & Dohme Llc Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof
CN111254103B (zh) * 2019-11-19 2023-06-02 河南省生物工程技术研究中心 一种非洲猪瘟基因工程疫苗高密度发酵补料培养基及发酵工艺
AU2021259110B2 (en) * 2020-04-20 2026-04-02 Evonik Operations Gmbh Compositions comprising Cys-peptides
EP4168032A2 (en) 2020-06-19 2023-04-26 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
CN114015622A (zh) * 2021-12-14 2022-02-08 塔里木大学 无乳链球菌培养基及其制备方法
WO2023131588A1 (en) * 2022-01-05 2023-07-13 Nordmark Pharma Gmbh Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases
CN114181872B (zh) * 2022-01-07 2023-11-24 北京大北农科技集团股份有限公司 一种屎肠球菌高密度发酵培养方法
KR102864280B1 (ko) * 2022-12-27 2025-09-26 (주)진성유니텍 포도상구균 증균을 위한 최소배지 및 이를 이용한 포도상구균 증균방법
KR102866798B1 (ko) * 2022-12-27 2025-10-01 (주)진성유니텍 살모넬라균 증균을 위한 최소배지 및 이를 이용한 살모넬라균 증균방법
CN117821342B (zh) * 2024-02-29 2024-06-04 北京民海生物科技有限公司 一种14型肺炎链球菌的发酵方法
KR102894728B1 (ko) 2024-11-27 2025-12-08 한국콜마주식회사 피지 생성 억제 효능, 모공 개선 효능 및 피부 장벽 강화 효능이 우수한 흑효모 발효물 및 이의 제조방법

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US7491517B2 (en) * 2006-07-19 2009-02-17 Jeeri R Reddy Method of producing meningococcal meningitis vaccine for Neisseria meningitidis serotypes A,C,Y, and W-135
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GB0818453D0 (en) * 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
WO2011151841A1 (en) 2010-05-31 2011-12-08 Panacea Biotec Limited Fermentation process for streptococcus pneumoniae
JP5763203B2 (ja) * 2011-05-17 2015-08-12 チャイナ ナショナル リサーチ インスティテュート オブ フード アンド ファーメンテーション インダストリーズ トウモロコシ降圧活性ペプチドを調製するための工業的方法
BR112014014656B1 (pt) * 2011-12-15 2020-03-17 Serum Institute Of India Ltd. Método de cultivo de bactérias para produção volumétrica superior de polioses capsulares em comparação com a fermentação em batelada
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Also Published As

Publication number Publication date
IL319202A (en) 2025-04-01
US20190292513A1 (en) 2019-09-26
KR20180073699A (ko) 2018-07-02
MX2021010518A (es) 2021-10-01
JP7311966B2 (ja) 2023-07-20
RU2018118035A (ru) 2019-12-18
HK1259103A1 (zh) 2019-11-22
US10947494B2 (en) 2021-03-16
CN108473945A (zh) 2018-08-31
IL259404B2 (en) 2025-08-01
KR102069988B1 (ko) 2020-01-23
AU2016357567B2 (en) 2020-05-07
CA3005308A1 (en) 2017-05-26
IL259404A (en) 2018-07-31
EP3377613A1 (en) 2018-09-26
US20210180008A1 (en) 2021-06-17
AU2016357567A1 (en) 2018-05-17
US20260008994A1 (en) 2026-01-08
JP2022017529A (ja) 2022-01-25
JP7814142B2 (ja) 2026-02-16
JP2018533366A (ja) 2018-11-15
WO2017085602A1 (en) 2017-05-26
BR112018008864A2 (pt) 2018-11-06
MX2018006063A (es) 2018-09-17
BR112018008864A8 (pt) 2019-02-26
IL259404B1 (en) 2025-04-01
RU2018118035A3 (https=) 2019-12-18
MX385736B (es) 2025-03-18
RU2761633C2 (ru) 2021-12-13
RU2021135165A (ru) 2021-12-29
CA3005308C (en) 2022-01-04
JP2024037949A (ja) 2024-03-19

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