CA3136821A1 - Proteines de liaison trispecifiques, procedes et utilisations connexes - Google Patents
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne des protéines de liaison trispécifiques et/ou trivalentes comprenant quatre chaînes polypeptidiques qui forment trois sites de liaison à l'antigène qui se lient de manière spécifique à une ou plusieurs protéines cibles, une première paire de polypeptides qui forme la protéine de liaison possédant des domaines variables doubles ayant une orientation croisée et une seconde paire de polypeptides possédant un domaine variable unique formant un site de liaison à l'antigène unique. Dans certains modes de réalisation, les protéines de liaison comprennent un site de liaison qui se lie à un polypeptide CD28, un site de liaison qui se lie à un polypeptide CDS, et un site de liaison qui se lie à un troisième polypeptide, tel qu'une protéine cible tumorale. L'invention concerne également des procédés de production de protéines de liaison trispécifiques et/ou trivalentes et des utilisations de telles protéines de liaison.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962831572P | 2019-04-09 | 2019-04-09 | |
| US62/831,572 | 2019-04-09 | ||
| EP19306261.9 | 2019-10-02 | ||
| EP19306261 | 2019-10-02 | ||
| PCT/US2020/027320 WO2020210392A1 (fr) | 2019-04-09 | 2020-04-08 | Protéines de liaison trispécifiques, procédés et utilisations connexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3136821A1 true CA3136821A1 (fr) | 2020-10-15 |
Family
ID=72751423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3136821A Pending CA3136821A1 (fr) | 2019-04-09 | 2020-04-08 | Proteines de liaison trispecifiques, procedes et utilisations connexes |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP3953388A1 (fr) |
| JP (1) | JP2022527994A (fr) |
| KR (1) | KR20210149141A (fr) |
| CN (1) | CN113950484A (fr) |
| AU (1) | AU2020272839A1 (fr) |
| BR (1) | BR112021019915A2 (fr) |
| CA (1) | CA3136821A1 (fr) |
| CO (1) | CO2021014918A2 (fr) |
| IL (1) | IL286929A (fr) |
| MX (1) | MX2021012386A (fr) |
| SG (1) | SG11202111012QA (fr) |
| TW (1) | TW202104261A (fr) |
| WO (1) | WO2020210392A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202104274A (zh) * | 2019-04-09 | 2021-02-01 | 法商賽諾菲公司 | 用於治療ｈｉｖ感染之三特異性及／或三價結合蛋白 |
| WO2024077118A2 (fr) * | 2022-10-06 | 2024-04-11 | Bicara Therapeutics Inc. | Protéines multispécifiques et procédés associés |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
| TWI588156B (zh) * | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| CA2996848C (fr) * | 2014-09-04 | 2021-01-05 | Stemcell Technologies Inc. | Complexes d'anticorps solubles pour l'activation et la proliferation de cellules t ou de cellules nk |
| BR112017007086A2 (pt) * | 2014-11-20 | 2018-01-16 | Hoffmann La Roche | moléculas de ligação, anticorpo biespecífico, variante de afinidade de uma molécula de ligação, polipeptídeos isolados, polinucleotídeos isolados, vetor, célula hospedeira, método para produzir a molécula de ligação, composição farmacêutica, uso da molécula de ligação, métodos de tratamento de uma doença e para induzir a lise de uma célula |
| JP7164949B2 (ja) * | 2014-11-20 | 2022-11-02 | エフ．ホフマン－ラ ロシュ アーゲー | 共通軽鎖および使用方法 |
| MY191964A (en) * | 2015-01-23 | 2022-07-21 | Sanofi Sa | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
| KR20180012859A (ko) * | 2015-06-17 | 2018-02-06 | 제넨테크, 인크. | 항-her2 항체 및 이용 방법 |
| US20180142010A1 (en) * | 2015-06-26 | 2018-05-24 | Alexion Pharmaceuticals, Inc. | Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| EA201891028A1 (ru) | 2015-10-25 | 2019-02-28 | Санофи | Триспецифические и/или тривалентные связывающие белки для предупреждения или лечения инфекции, вызываемой hiv |
| IL262241B2 (en) * | 2016-04-13 | 2024-05-01 | Sanofi Sa | Trispecific and/or trivalent binding proteins with an arm that has a cross-linking dual variable domain and a traditional FAB antibody arm, the pharmaceutical composition that includes said binding proteins and their uses in the prevention and/or treatment of cancer or inflammatory diseases |
| EP3484516A4 (fr) * | 2016-07-14 | 2020-03-18 | Fred Hutchinson Cancer Research Center | Constructions multiples de domaines de liaison bi-spécifiques ayant une liaison à l'épitope différente pour traiter le cancer |
| US20230242876A1 (en) * | 2016-12-30 | 2023-08-03 | Shanghai Sinobio Biotech Co., Ltd. | Bifunctional molecule and use thereof |
| BR112020007002A2 (pt) * | 2017-10-10 | 2020-11-17 | Sanofi | anticorpos anti-cd38 e métodos de uso |
| CN113166254A (zh) * | 2018-10-09 | 2021-07-23 | 赛诺菲 | 三特异性抗cd38、抗cd28和抗cd3结合蛋白和用于治疗病毒感染的使用方法 |
-
2020
- 2020-04-08 KR KR1020217036094A patent/KR20210149141A/ko unknown
- 2020-04-08 EP EP20722422.1A patent/EP3953388A1/fr active Pending
- 2020-04-08 SG SG11202111012QA patent/SG11202111012QA/en unknown
- 2020-04-08 CA CA3136821A patent/CA3136821A1/fr active Pending
- 2020-04-08 WO PCT/US2020/027320 patent/WO2020210392A1/fr unknown
- 2020-04-08 JP JP2021559759A patent/JP2022527994A/ja active Pending
- 2020-04-08 TW TW109111809A patent/TW202104261A/zh unknown
- 2020-04-08 BR BR112021019915A patent/BR112021019915A2/pt unknown
- 2020-04-08 CN CN202080041550.1A patent/CN113950484A/zh active Pending
- 2020-04-08 AU AU2020272839A patent/AU2020272839A1/en active Pending
- 2020-04-08 MX MX2021012386A patent/MX2021012386A/es unknown
-
2021
- 2021-10-03 IL IL286929A patent/IL286929A/en unknown
- 2021-11-04 CO CONC2021/0014918A patent/CO2021014918A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020272839A1 (en) | 2021-12-02 |
| CN113950484A (zh) | 2022-01-18 |
| IL286929A (en) | 2021-10-31 |
| EP3953388A1 (fr) | 2022-02-16 |
| SG11202111012QA (en) | 2021-11-29 |
| CO2021014918A2 (es) | 2021-11-19 |
| WO2020210392A1 (fr) | 2020-10-15 |
| MX2021012386A (es) | 2022-01-18 |
| JP2022527994A (ja) | 2022-06-07 |
| BR112021019915A2 (pt) | 2021-12-07 |
| TW202104261A (zh) | 2021-02-01 |
| KR20210149141A (ko) | 2021-12-08 |
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