IL286929A - Trispecific binding proteins, methods, and uses thereof - Google Patents
Trispecific binding proteins, methods, and uses thereofInfo
- Publication number
- IL286929A IL286929A IL286929A IL28692921A IL286929A IL 286929 A IL286929 A IL 286929A IL 286929 A IL286929 A IL 286929A IL 28692921 A IL28692921 A IL 28692921A IL 286929 A IL286929 A IL 286929A
- Authority
- IL
- Israel
- Prior art keywords
- methods
- binding proteins
- trispecific binding
- trispecific
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962831572P | 2019-04-09 | 2019-04-09 | |
EP19306261 | 2019-10-02 | ||
PCT/US2020/027320 WO2020210392A1 (en) | 2019-04-09 | 2020-04-08 | Trispecific binding proteins, methods, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL286929A true IL286929A (en) | 2021-10-31 |
Family
ID=72751423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL286929A IL286929A (en) | 2019-04-09 | 2021-10-03 | Trispecific binding proteins, methods, and uses thereof |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP3953388A1 (en) |
JP (1) | JP2022527994A (en) |
KR (1) | KR20210149141A (en) |
CN (1) | CN113950484A (en) |
AU (1) | AU2020272839A1 (en) |
BR (1) | BR112021019915A2 (en) |
CA (1) | CA3136821A1 (en) |
CO (1) | CO2021014918A2 (en) |
IL (1) | IL286929A (en) |
MX (1) | MX2021012386A (en) |
SG (1) | SG11202111012QA (en) |
TW (1) | TW202104261A (en) |
WO (1) | WO2020210392A1 (en) |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
JOP20210044A1 (en) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | Anti-cd38 antibodies |
TWI803876B (en) * | 2011-03-28 | 2023-06-01 | 法商賽諾菲公司 | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
CA2996848C (en) * | 2014-09-04 | 2021-01-05 | Stemcell Technologies Inc. | Soluble antibody complexes for t cell or nk cell activation and expansion |
TW202130662A (en) * | 2015-01-23 | 2021-08-16 | 法商賽諾菲公司 | Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123 |
AU2016280159A1 (en) * | 2015-06-17 | 2017-12-07 | Genentech, Inc. | Anti-HER2 antibodies and methods of use |
CN116675776A (en) | 2015-10-25 | 2023-09-01 | 赛诺菲 | Trispecific and/or trivalent binding proteins for the prevention or treatment of HIV infection |
CR20180539A (en) | 2016-04-13 | 2019-02-15 | Sanofi Sa | THREE-SPECIFIC AND / OR TRIVAL UNION PROTEINS |
US20230242876A1 (en) * | 2016-12-30 | 2023-08-03 | Shanghai Sinobio Biotech Co., Ltd. | Bifunctional molecule and use thereof |
JP7036909B2 (en) * | 2017-10-10 | 2022-03-15 | サノフイ | Anti-CD38 antibody and usage |
CN113166254A (en) * | 2018-10-09 | 2021-07-23 | 赛诺菲 | Trispecific anti-CD 38, anti-CD 28, and anti-CD 3 binding proteins and methods of use for treating viral infections |
-
2020
- 2020-04-08 JP JP2021559759A patent/JP2022527994A/en active Pending
- 2020-04-08 AU AU2020272839A patent/AU2020272839A1/en active Pending
- 2020-04-08 TW TW109111809A patent/TW202104261A/en unknown
- 2020-04-08 SG SG11202111012QA patent/SG11202111012QA/en unknown
- 2020-04-08 EP EP20722422.1A patent/EP3953388A1/en active Pending
- 2020-04-08 CA CA3136821A patent/CA3136821A1/en active Pending
- 2020-04-08 WO PCT/US2020/027320 patent/WO2020210392A1/en unknown
- 2020-04-08 KR KR1020217036094A patent/KR20210149141A/en unknown
- 2020-04-08 BR BR112021019915A patent/BR112021019915A2/en unknown
- 2020-04-08 MX MX2021012386A patent/MX2021012386A/en unknown
- 2020-04-08 CN CN202080041550.1A patent/CN113950484A/en active Pending
-
2021
- 2021-10-03 IL IL286929A patent/IL286929A/en unknown
- 2021-11-04 CO CONC2021/0014918A patent/CO2021014918A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN113950484A (en) | 2022-01-18 |
SG11202111012QA (en) | 2021-11-29 |
AU2020272839A1 (en) | 2021-12-02 |
CO2021014918A2 (en) | 2021-11-19 |
MX2021012386A (en) | 2022-01-18 |
WO2020210392A1 (en) | 2020-10-15 |
TW202104261A (en) | 2021-02-01 |
EP3953388A1 (en) | 2022-02-16 |
BR112021019915A2 (en) | 2021-12-07 |
JP2022527994A (en) | 2022-06-07 |
KR20210149141A (en) | 2021-12-08 |
CA3136821A1 (en) | 2020-10-15 |
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