BR112021019915A2 - Proteínas de ligação triespecíficas, métodos e usos dos mesmos - Google Patents
Proteínas de ligação triespecíficas, métodos e usos dos mesmosInfo
- Publication number
- BR112021019915A2 BR112021019915A2 BR112021019915A BR112021019915A BR112021019915A2 BR 112021019915 A2 BR112021019915 A2 BR 112021019915A2 BR 112021019915 A BR112021019915 A BR 112021019915A BR 112021019915 A BR112021019915 A BR 112021019915A BR 112021019915 A2 BR112021019915 A2 BR 112021019915A2
- Authority
- BR
- Brazil
- Prior art keywords
- binding
- binding proteins
- methods
- polypeptide
- proteins
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title abstract 6
- 108091008324 binding proteins Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
proteínas de ligação triespecíficas, métodos e usos dos mesmos. a presente invenção refere-se a proteínas de ligação triespecíficas e/ou trivalentes compreendendo quatro cadeias de polipeptídeo que formam três sítios de ligação ao antígeno que especificamente se ligam a uma ou mais proteínas alvo, em que um primeiro par de polipeptídeos formando a proteína de ligação possui domínios variáveis duplos tendo uma orientação cruzada, e em que um segundo par de polipeptídeos possui um domínio variável único formando um sítio de ligação ao antígeno único. em algumas formas de realização, as proteínas de ligação compreendem um sítio de ligação que se liga a um polipeptídeo cd28, um sítio de ligação que se liga a um polipeptídeo cd3, e um sítio de ligação que se liga um terceiro polipeptídeo, tal como, uma proteína alvo de tumor. a invenção também se refere a métodos para preparar proteínas de ligação triespecíficas e/ou trivalentes e usos de tais proteínas de ligação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962831572P | 2019-04-09 | 2019-04-09 | |
EP19306261 | 2019-10-02 | ||
PCT/US2020/027320 WO2020210392A1 (en) | 2019-04-09 | 2020-04-08 | Trispecific binding proteins, methods, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021019915A2 true BR112021019915A2 (pt) | 2021-12-07 |
Family
ID=72751423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021019915A BR112021019915A2 (pt) | 2019-04-09 | 2020-04-08 | Proteínas de ligação triespecíficas, métodos e usos dos mesmos |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP3953388A1 (pt) |
JP (1) | JP2022527994A (pt) |
KR (1) | KR20210149141A (pt) |
CN (1) | CN113950484A (pt) |
AU (1) | AU2020272839A1 (pt) |
BR (1) | BR112021019915A2 (pt) |
CA (1) | CA3136821A1 (pt) |
CO (1) | CO2021014918A2 (pt) |
IL (1) | IL286929A (pt) |
MX (1) | MX2021012386A (pt) |
SG (1) | SG11202111012QA (pt) |
TW (1) | TW202104261A (pt) |
WO (1) | WO2020210392A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024077118A2 (en) * | 2022-10-06 | 2024-04-11 | Bicara Therapeutics Inc. | Multispecific proteins and related methods |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9200061B2 (en) * | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
JOP20210044A1 (ar) * | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
TWI803876B (zh) * | 2011-03-28 | 2023-06-01 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
ES2808914T3 (es) * | 2014-09-04 | 2021-03-02 | Stemcell Tech Inc | Complejos de anticuerpo solubles para la activación y expansión de linfocitos T o células NK |
BR112017014805A2 (pt) * | 2015-01-23 | 2018-01-09 | Sanofi | anticorpos anti-cd3, anticorpos anti-cd123 e anticorpos biespecíficos que se ligam especificamente a cd3 e/ou cd123 |
JP2018524312A (ja) * | 2015-06-17 | 2018-08-30 | ジェネンテック, インコーポレイテッド | 抗her2抗体及び使用方法 |
RS62437B1 (sr) | 2015-10-25 | 2021-11-30 | Sanofi Sa | Trispecifični i/ili trivalentni vezujući proteini za prevenciju ili lečenje hiv infekcije |
WO2018120842A1 (zh) * | 2016-12-30 | 2018-07-05 | 上海欣百诺生物科技有限公司 | 一种双功能分子及其应用 |
EA201892312A1 (ru) | 2017-03-17 | 2019-04-30 | Санофи | Триспецифические и/или тривалентные связывающие белки |
CN117964758A (zh) * | 2017-10-10 | 2024-05-03 | 赛诺菲 | 抗cd38抗体及与抗cd3和抗cd28抗体的组合 |
BR112021006558A2 (pt) * | 2018-10-09 | 2021-07-13 | Sanofi | proteínas de ligação triespecíficas anti-cd38, anti-cd28 e anti-cd3 e métodos de uso para o tratamento de infecção viral |
-
2020
- 2020-04-08 WO PCT/US2020/027320 patent/WO2020210392A1/en unknown
- 2020-04-08 CN CN202080041550.1A patent/CN113950484A/zh active Pending
- 2020-04-08 AU AU2020272839A patent/AU2020272839A1/en active Pending
- 2020-04-08 SG SG11202111012QA patent/SG11202111012QA/en unknown
- 2020-04-08 CA CA3136821A patent/CA3136821A1/en active Pending
- 2020-04-08 MX MX2021012386A patent/MX2021012386A/es unknown
- 2020-04-08 BR BR112021019915A patent/BR112021019915A2/pt unknown
- 2020-04-08 KR KR1020217036094A patent/KR20210149141A/ko unknown
- 2020-04-08 JP JP2021559759A patent/JP2022527994A/ja active Pending
- 2020-04-08 EP EP20722422.1A patent/EP3953388A1/en active Pending
- 2020-04-08 TW TW109111809A patent/TW202104261A/zh unknown
-
2021
- 2021-10-03 IL IL286929A patent/IL286929A/en unknown
- 2021-11-04 CO CONC2021/0014918A patent/CO2021014918A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP3953388A1 (en) | 2022-02-16 |
CN113950484A (zh) | 2022-01-18 |
AU2020272839A1 (en) | 2021-12-02 |
WO2020210392A1 (en) | 2020-10-15 |
JP2022527994A (ja) | 2022-06-07 |
TW202104261A (zh) | 2021-02-01 |
CA3136821A1 (en) | 2020-10-15 |
KR20210149141A (ko) | 2021-12-08 |
IL286929A (en) | 2021-10-31 |
SG11202111012QA (en) | 2021-11-29 |
MX2021012386A (es) | 2022-01-18 |
CO2021014918A2 (es) | 2021-11-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018008011A2 (pt) | proteínas de ligação triespecíficas e/ou trivalentes para prevenção ou tratamento de infecção por hiv | |
EA201892312A1 (ru) | Триспецифические и/или тривалентные связывающие белки | |
MX2022009947A (es) | Anticuerpos y proteinas de fusion que se unen a ccr8 y usos de estos. | |
MX2023007520A (es) | Aglutinantes de albumina de suero mejorados. | |
MX2023005374A (es) | Aglutinantes de albumina serica mejorados. | |
UY37928A (es) | Anticuerpos anti-cd38 y métodos de uso | |
CY1124944T1 (el) | Βελτιστοποιημενα αμφιειδικα αντισωματα αντι-cd3 και χρησεις αυτων | |
CY1122564T1 (el) | Μορια δεσμευσης μονhς αλυσιδας που περιλαμβανουν ν-τελικο αβρ | |
MX2019008536A (es) | Aglutinantes de albumina serica mejorados. | |
EA201892691A1 (ru) | Однодоменный белок, связывающий сывороточный альбумин | |
BR112018005573A2 (pt) | ?polipeptídeos de ligação a cd3? | |
BR112017019785A2 (pt) | anticorpos terapêuticos e seus usos | |
BR112018002451A2 (pt) | estruturas de ligação com antígeno para moléculas alvo | |
BR112018010084A2 (pt) | ligantes de pd1 e/ou lag3 | |
EA201692504A1 (ru) | Триспецифичные связывающие молекулы и способы их применения | |
BR112017014771A2 (pt) | ?anticorpo, polinucleotídeo, unidade de expressão, célula hospedeira, métodos para produção de um anticorpo e para tratamento de um indivíduo, composição, uso de um anticorpo em um método de diagnóstico, e, vetor de expressão? | |
PH12019500609A1 (en) | Cd123 binding proteins and related compositions and methods | |
EA201290570A1 (ru) | Конструкты, связывающиеся с ron, и способы их использования | |
EA201890320A1 (ru) | Молекулы антител, которые связывают cd79 | |
BR112018069890A2 (pt) | polipeptídio de fusão que se liga de forma específica a um alvo, polipeptídio de fusão dimérico, ácido nucleico isolado, par de ácidos nucleicos isolados, célula hospedeira, método para produzir um polipeptídio de fusão, imunoconjugado, formulação farmacêutica, polipeptídio de fusão e uso do polipeptídio de fusão | |
BR112014001573B8 (pt) | Molécula fv ao antígeno multivalente | |
PH12020500137A1 (en) | Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods | |
MX2022009915A (es) | Anticuerpos anti-ror2, fragmentos de anticuerpos, sus inmunoconjugados y usos de los mismos. | |
BR112022011570A2 (pt) | Anticorpos anti-mertk e métodos de uso dos mesmos | |
EA202092085A1 (ru) | ТЕРАПЕВТИЧЕСКИЕ АНТИТЕЛА ПРОТИВ sPLA2-GIB И ИХ ПРИМЕНЕНИЕ |