CA3104896A1 - Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature - Google Patents
Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature Download PDFInfo
- Publication number
- CA3104896A1 CA3104896A1 CA3104896A CA3104896A CA3104896A1 CA 3104896 A1 CA3104896 A1 CA 3104896A1 CA 3104896 A CA3104896 A CA 3104896A CA 3104896 A CA3104896 A CA 3104896A CA 3104896 A1 CA3104896 A1 CA 3104896A1
- Authority
- CA
- Canada
- Prior art keywords
- electrode
- biosensor
- enzyme
- enzymes
- creatinine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
- B01D67/00091—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching by evaporation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
- B01D67/0011—Casting solutions therefor
- B01D67/00111—Polymer pretreatment in the casting solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
- B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
- B01D67/0013—Casting processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/10—Supported membranes; Membrane supports
- B01D69/107—Organic support material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
- B01D69/1213—Laminated layers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/14—Dynamic membranes
- B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
- B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
- B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/54—Polyureas; Polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/002—Electrode membranes
- C12Q1/003—Functionalisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
- G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/30—Microarray design
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2323/00—Details relating to membrane preparation
- B01D2323/12—Specific ratios of components used
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2325/00—Details relating to properties of membranes
- B01D2325/34—Molecular weight or degree of polymerisation
- B01D2325/341—At least two polymers of same structure but different molecular weight
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F30/00—Computer-aided design [CAD]
- G06F30/30—Circuit design
- G06F30/32—Circuit design at the digital level
- G06F30/33—Design verification, e.g. functional simulation or model checking
- G06F30/3308—Design verification, e.g. functional simulation or model checking using simulation
- G06F30/331—Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Electrochemistry (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Data Mining & Analysis (AREA)
- Dispersion Chemistry (AREA)
- Computational Mathematics (AREA)
- Pure & Applied Mathematics (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Mathematical Analysis (AREA)
- Evolutionary Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830191P | 2019-04-05 | 2019-04-05 | |
| US62/830,191 | 2019-04-05 | ||
| PCT/US2019/035156 WO2020204975A1 (en) | 2019-04-05 | 2019-06-03 | Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3104896A1 true CA3104896A1 (en) | 2020-10-08 |
Family
ID=67138031
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3104896A Pending CA3104896A1 (en) | 2019-04-05 | 2019-06-03 | Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature |
| CA3105191A Pending CA3105191A1 (en) | 2019-04-05 | 2019-06-03 | Urea biosensors and stabilization of urea biosensors at room temperature |
| CA3105013A Active CA3105013C (en) | 2019-04-05 | 2019-06-03 | Outer membrane compositions for creatinine/creatine sensors |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3105191A Pending CA3105191A1 (en) | 2019-04-05 | 2019-06-03 | Urea biosensors and stabilization of urea biosensors at room temperature |
| CA3105013A Active CA3105013C (en) | 2019-04-05 | 2019-06-03 | Outer membrane compositions for creatinine/creatine sensors |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US11761921B2 (enExample) |
| EP (5) | EP3946697B1 (enExample) |
| JP (6) | JP7100162B2 (enExample) |
| KR (5) | KR102574622B1 (enExample) |
| CN (6) | CN112534058B (enExample) |
| AU (3) | AU2019439424B2 (enExample) |
| CA (3) | CA3104896A1 (enExample) |
| DK (2) | DK3947708T3 (enExample) |
| ES (1) | ES3038379T3 (enExample) |
| WO (5) | WO2020204973A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7100162B2 (ja) * | 2019-04-05 | 2022-07-12 | インストゥルメンテーション ラボラトリー カンパニー | 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用 |
| US12139741B2 (en) | 2019-10-25 | 2024-11-12 | Instrumentation Laboratory Company | Biocide compositions compatible with enzyme biosensors and methods of use thereof |
| US12298268B2 (en) * | 2020-05-21 | 2025-05-13 | Nova Biomedical Corporation | Single-use disposable reference sensor |
| WO2023015187A1 (en) * | 2021-08-03 | 2023-02-09 | Polymer Technology Systems, Inc. | Systems and methods for quantifying the specific activity of creatininase |
| EP4476537B1 (en) | 2022-02-09 | 2025-10-29 | Instrumentation Laboratory Company | Sensor for measuring ionized magnesium |
| CN114705674B (zh) * | 2022-05-10 | 2025-07-22 | 光景生物科技(苏州)有限公司 | 一种全血中肌酸和肌酐的定量检测方法 |
| AU2024316973A1 (en) * | 2023-07-31 | 2026-01-22 | Abbott Diabetes Care Inc. | Background interference mitigation for high sensitivity creatinine sensing |
| KR102800865B1 (ko) | 2024-07-31 | 2025-05-07 | 전남대학교 산학협력단 | 신규한 크레아티닌 정량 장치 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5861459A (ja) * | 1981-10-07 | 1983-04-12 | Hitachi Ltd | クレアチンとクレアチニンの分析装置 |
| JPS6475000A (en) | 1987-09-14 | 1989-03-20 | Shimadzu Corp | Method and equipment for analyzing creatinine |
| US5464747A (en) * | 1993-10-29 | 1995-11-07 | Boehringer Mannheim Corporation | Oxidation-resistant muteins of β-galactosidase fragments |
| EP0944731B1 (en) * | 1996-11-14 | 2006-01-18 | Radiometer Medical ApS | Enzyme sensor |
| DE69810194T2 (de) * | 1997-06-03 | 2003-11-20 | Matsushita Electric Industrial Co. Ltd., Osaka | Cholesterinsensor |
| JP3635263B2 (ja) | 2000-03-01 | 2005-04-06 | ラジオメーター・メディカル・アクティーゼルスカブ | 固体状態参照系を持つ電極デバイス |
| AT408662B (de) * | 2000-05-16 | 2002-02-25 | Hoffmann La Roche | Creatinin-sensor |
| AT409040B (de) | 2000-08-11 | 2002-05-27 | Roche Diagnostics Gmbh | Creatininsensor-kalibration |
| US6960466B2 (en) | 2001-05-31 | 2005-11-01 | Instrumentation Laboratory Company | Composite membrane containing a cross-linked enzyme matrix for a biosensor |
| US6872297B2 (en) * | 2001-05-31 | 2005-03-29 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
| US6767441B1 (en) | 2001-07-31 | 2004-07-27 | Nova Biomedical Corporation | Biosensor with peroxidase enzyme |
| ES2355333T3 (es) * | 2001-08-22 | 2011-03-24 | Instrumentation Laboratory Company | Método y aparato para calibrar sensores . |
| AU2002321531B2 (en) | 2001-08-24 | 2007-12-13 | Sensortec Limited | Methods for producing highly sensitive potentiometric sensors |
| US7285198B2 (en) | 2004-02-23 | 2007-10-23 | Mysticmd, Inc. | Strip electrode with conductive nano tube printing |
| GB0227424D0 (en) * | 2002-11-25 | 2002-12-31 | Univ Warwick | Coatings |
| US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
| EP1679508B1 (en) | 2003-10-30 | 2010-07-21 | Arkray, Inc. | Biosensor and method for preparation thereof |
| DK1692522T3 (da) | 2003-11-28 | 2012-04-02 | Radiometer Medical Aps | Referencevæske |
| US7699964B2 (en) * | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
| US7946984B2 (en) * | 2004-07-13 | 2011-05-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| EP1885870A1 (en) | 2005-05-17 | 2008-02-13 | Radiometer Medical ApS | Enzyme sensor including a water-containing spacer layer |
| CN102608176B (zh) | 2005-05-17 | 2016-08-10 | 雷迪奥米特医学公司 | 用二价锰离子溶液稳定或再活化肌酸酐传感器的方法 |
| WO2006122552A1 (en) | 2005-05-17 | 2006-11-23 | Radiometer Medical Aps | Method of stabilising or reactivating a creatinine sensor with a solution of a divalent manganese ion |
| US7959791B2 (en) | 2005-05-17 | 2011-06-14 | Radiometer Medical Aps | Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer |
| KR100726963B1 (ko) * | 2005-06-15 | 2007-06-14 | 김경훈 | 바이오센서용 우레아제 고정화막의 제조 방법 |
| US7799195B2 (en) * | 2005-09-02 | 2010-09-21 | Vladislav Dolnik | Neutral polysaccharide wall coating for electrophoretic separations in capillaries and microchannels |
| US8617366B2 (en) * | 2005-12-12 | 2013-12-31 | Nova Biomedical Corporation | Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device |
| US9556471B2 (en) * | 2006-08-09 | 2017-01-31 | Flir Detection, Inc. | Enzyme containing liquid and delivery system for detection of analytes on surfaces |
| US7687103B2 (en) | 2006-08-31 | 2010-03-30 | Gamida For Life B.V. | Compositions and methods for preserving permeation layers for use on active electronic matrix devices |
| IES20070774A2 (en) | 2007-10-24 | 2008-12-24 | Nat Univ Ireland Maynooth | Monitoring target endogenous species in the brain |
| US8268604B2 (en) | 2007-12-20 | 2012-09-18 | Abbott Point Of Care Inc. | Compositions for forming immobilized biological layers for sensing |
| WO2011037702A1 (en) | 2009-09-24 | 2011-03-31 | Fresenius Medical Care Holdings, Inc. | Amperometric creatinine biosensor with immobilized enzyme-polymer composition and systems using same, and methods |
| US9233788B2 (en) | 2010-01-22 | 2016-01-12 | Bayer Healthcare Llc | Biosensor desiccant system having enhanced measurement performance |
| JP2014153243A (ja) | 2013-02-12 | 2014-08-25 | Tanita Corp | バイオセンサおよびこれを用いた測定方法 |
| EP2972275B1 (en) | 2013-03-14 | 2019-07-10 | Instrumentation Laboratory Company | Whole blood hemolysis sensor |
| US9487811B2 (en) * | 2013-03-15 | 2016-11-08 | Abbott Point Of Care Inc. | Biosensor structures for improved point of care testing and methods of manufacture thereof |
| WO2016096725A1 (en) | 2014-12-18 | 2016-06-23 | Radiometer Medical Aps | Method for calibrating a device for measuring the concentration of creatinine |
| WO2016096683A1 (en) | 2014-12-18 | 2016-06-23 | Radiometer Medical | Calibration concept for amperometric creatinine sensor correcting for endogenous modulators |
| DK3234564T3 (da) | 2014-12-18 | 2025-02-10 | Radiometer Medical Aps | Fremgangsmåde til kalibrering af en indretning til måling af koncentrationen af kreatinin |
| CN108291889B (zh) | 2015-11-27 | 2021-03-12 | 雷迪奥米特医学公司 | 用于酶传感器的外层 |
| JP7011906B2 (ja) | 2017-08-25 | 2022-01-27 | 国立大学法人 筑波大学 | クレアチニンセンサ |
| EP3676306B1 (en) | 2017-08-28 | 2022-05-25 | DSM IP Assets B.V. | Synthetic membrane composition comprising polyurethane blend |
| JP7100162B2 (ja) | 2019-04-05 | 2022-07-12 | インストゥルメンテーション ラボラトリー カンパニー | 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用 |
-
2019
- 2019-06-03 JP JP2020570732A patent/JP7100162B2/ja active Active
- 2019-06-03 US US16/430,057 patent/US11761921B2/en active Active
- 2019-06-03 CN CN201980043624.2A patent/CN112534058B/zh active Active
- 2019-06-03 AU AU2019439424A patent/AU2019439424B2/en active Active
- 2019-06-03 WO PCT/US2019/035153 patent/WO2020204973A1/en not_active Ceased
- 2019-06-03 EP EP19740656.4A patent/EP3946697B1/en active Active
- 2019-06-03 AU AU2019439465A patent/AU2019439465B2/en active Active
- 2019-06-03 WO PCT/US2019/035157 patent/WO2020204976A1/en not_active Ceased
- 2019-06-03 WO PCT/US2019/035155 patent/WO2020204974A1/en not_active Ceased
- 2019-06-03 CN CN201980042702.7A patent/CN112424369A/zh active Pending
- 2019-06-03 US US16/429,886 patent/US12529673B2/en active Active
- 2019-06-03 JP JP2020570972A patent/JP7015401B2/ja active Active
- 2019-06-03 KR KR1020207037324A patent/KR102574622B1/ko active Active
- 2019-06-03 ES ES19740656T patent/ES3038379T3/es active Active
- 2019-06-03 WO PCT/US2019/035152 patent/WO2020204972A1/en not_active Ceased
- 2019-06-03 JP JP2020570928A patent/JP7135121B2/ja active Active
- 2019-06-03 EP EP19734962.4A patent/EP3947708B1/en active Active
- 2019-06-03 JP JP2020571701A patent/JP7127159B2/ja active Active
- 2019-06-03 KR KR1020207037741A patent/KR102937635B1/ko active Active
- 2019-06-03 KR KR1020207037321A patent/KR102480669B1/ko active Active
- 2019-06-03 CN CN201980043652.4A patent/CN112534059B/zh active Active
- 2019-06-03 CN CN201980045247.6A patent/CN112513285B/zh active Active
- 2019-06-03 EP EP19734963.2A patent/EP3947709A1/en active Pending
- 2019-06-03 KR KR1020207037318A patent/KR102519406B1/ko active Active
- 2019-06-03 KR KR1020207037316A patent/KR102519408B1/ko active Active
- 2019-06-03 EP EP19739734.2A patent/EP3947711B1/en active Active
- 2019-06-03 CA CA3104896A patent/CA3104896A1/en active Pending
- 2019-06-03 WO PCT/US2019/035156 patent/WO2020204975A1/en not_active Ceased
- 2019-06-03 JP JP2020567148A patent/JP7082691B2/ja active Active
- 2019-06-03 DK DK19734962.4T patent/DK3947708T3/da active
- 2019-06-03 CN CN201980043651.XA patent/CN112638513A/zh active Pending
- 2019-06-03 US US16/429,922 patent/US11293890B2/en active Active
- 2019-06-03 DK DK19739734.2T patent/DK3947711T3/da active
- 2019-06-03 CA CA3105191A patent/CA3105191A1/en active Pending
- 2019-06-03 US US16/430,028 patent/US11460431B2/en active Active
- 2019-06-03 US US16/429,993 patent/US11327042B2/en active Active
- 2019-06-03 CN CN202411896882.4A patent/CN119776481A/zh active Pending
- 2019-06-03 EP EP19734964.0A patent/EP3947710A1/en active Pending
- 2019-06-03 AU AU2019440163A patent/AU2019440163B2/en active Active
- 2019-06-03 CA CA3105013A patent/CA3105013C/en active Active
-
2022
- 2022-02-18 JP JP2022024293A patent/JP2022068299A/ja active Pending
- 2022-02-25 US US17/680,487 patent/US20220187234A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220187234A1 (en) | Multi-enzymatic biosensors and stabilization of multi-enzymatic biosensors at room temperature | |
| Berners et al. | Online measurement of brain glutamate with an enzyme/polymer-coated tubular electrode | |
| Vadgama | Enzyme electrodes as practical biosensors | |
| US7888061B2 (en) | Method of stabilising or reactivating a creatinine sensor with a divalent manganese ion | |
| Palleschi et al. | Ideal hydrogen peroxide-based glucose sensor | |
| WO2006058779A1 (en) | Diffusion and enzyme layer for an enzyme-based sensor application | |
| Yuan et al. | Eliminating the interference of ascorbic acid and uric acid to the amperometric glucose biosensor by cation exchangers membrane and size exclusion membrane | |
| JP2021524587A5 (enExample) | ||
| Palmisano et al. | An in situ electrosynthesized amperometric biosensor based on lactate oxidase immobilized in a poly-o-phenylenediamine film: Determination of lactate in serum by flow injection analysis | |
| Rhemrev-Boom et al. | On-line continuous monitoring of glucose or lactate by ultraslow microdialysis combined with a flow-through nanoliter biosensor based on poly (m-phenylenediamine) ultra-thin polymer membrane as enzyme electrode | |
| Ferri et al. | A Glucose Biosensor Based on Electro‐Enzyme Catalyzed Oxidation of Glucose Using a HRP‐GOD Layered Assembly | |
| Guilbault et al. | Preparation and analytical uses of immobilized enzymes | |
| Böhm et al. | A flow-through amperometric sensor based on dialysis tubing and free enzyme reactors | |
| Compagnone et al. | Amperometric glutathione electrodes | |
| Collins et al. | Interference elimination in glutamate monitoring with chip integrated enzyme microreactors | |
| Campanella et al. | Enzyme-entrapping membranes for enzyme sensors | |
| Demirkiran et al. | Immobilization of glucose oxidase in silica sol-gel film for application to biosensor and amperometric determination of glucose | |
| Vokhmyanina et al. | Prussian Blue-Based Thin-Layer Flow-Injection Multibiosensor for Simultaneous Determination of Glucose and Lactate | |
| Boero et al. | Long-term biosensors for metabolite monitoring by using carbon nanotubes | |
| Yasukawa et al. | Immobilization of glucose oxidase on a poly (dimethylsiloxane) layer by using poly (L-lysine) as a polymer backbone | |
| LEEb | Assay Galactose by Biosensors | |
| CS241022B2 (cs) | Molekulárně selektivní senzor a způsob jeho výroby | |
| Shaban | Comparison of Two Glucose-detecting Carbon Paste Electrodes using Different Enzyme Immobilization Techniques | |
| HK1116834A (en) | Diffusion and enzyme layer for an enzyme-based sensor application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20201222 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION Effective date: 20240711 |
|
| B12 | Application deemed to be withdrawn, abandoned or lapsed |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION Effective date: 20240916 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT Effective date: 20241231 |
|
| P11 | Amendment of application requested |
Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT Effective date: 20250116 |
|
| P13 | Application amended |
Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED Effective date: 20250116 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 6TH ANNIV.) - STANDARD Year of fee payment: 6 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250530 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250530 |
|
| MFA | Maintenance fee for application paid |
Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 7TH ANNIV.) - STANDARD Year of fee payment: 7 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20260529 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-2-2-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20260529 |
|
| D22 | Grant of ip right intended |
Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D22-D128 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: ALLOWANCE REQUIREMENTS DETERMINED COMPLIANT Effective date: 20260624 |
|
| W00 | Other event occurred |
Free format text: ST27 STATUS EVENT CODE: A-2-2-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT Effective date: 20260625 |