KR102574622B1 - 개선된 크레아티닌 측정 정확도를 위한 조성물과 방법, 및 그것의 사용 - Google Patents

개선된 크레아티닌 측정 정확도를 위한 조성물과 방법, 및 그것의 사용 Download PDF

Info

Publication number
KR102574622B1
KR102574622B1 KR1020207037324A KR20207037324A KR102574622B1 KR 102574622 B1 KR102574622 B1 KR 102574622B1 KR 1020207037324 A KR1020207037324 A KR 1020207037324A KR 20207037324 A KR20207037324 A KR 20207037324A KR 102574622 B1 KR102574622 B1 KR 102574622B1
Authority
KR
South Korea
Prior art keywords
creatinine
creatine
sensor
bmcs2
bmcs3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020207037324A
Other languages
English (en)
Korean (ko)
Other versions
KR20210013626A (ko
Inventor
시아오시안 쉬
프라사드 파미디
데이비드 래이몬디
루치카 말호트라
매튜 컬리
Original Assignee
인스트루멘테이션 래보라토리 컴퍼니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인스트루멘테이션 래보라토리 컴퍼니 filed Critical 인스트루멘테이션 래보라토리 컴퍼니
Publication of KR20210013626A publication Critical patent/KR20210013626A/ko
Application granted granted Critical
Publication of KR102574622B1 publication Critical patent/KR102574622B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/00091—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching by evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0011—Casting solutions therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0011—Casting solutions therefor
    • B01D67/00111—Polymer pretreatment in the casting solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B01D67/0009—Organic membrane manufacture by phase separation, sol-gel transition, evaporation or solvent quenching
    • B01D67/0013—Casting processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/107—Organic support material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • B01D69/1213—Laminated layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/142—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers"
    • B01D69/144—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes with "carriers" containing embedded or bound biomolecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/54—Polyureas; Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C12Q1/003—Functionalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/58—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving urea or urease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/308—Electrodes, e.g. test electrodes; Half-cells at least partially made of carbon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274—Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F30/00—Computer-aided design [CAD]
    • G06F30/30—Circuit design
    • G06F30/32—Circuit design at the digital level
    • G06F30/33—Design verification, e.g. functional simulation or model checking
    • G06F30/3308—Design verification, e.g. functional simulation or model checking using simulation
    • G06F30/331—Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/30—Microarray design
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2323/00—Details relating to membrane preparation
    • B01D2323/12—Specific ratios of components used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/34—Molecular weight or degree of polymerisation
    • B01D2325/341—At least two polymers of same structure but different molecular weight
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Electrochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Data Mining & Analysis (AREA)
  • Dispersion Chemistry (AREA)
  • Computational Mathematics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Mathematical Analysis (AREA)
  • Evolutionary Biology (AREA)
KR1020207037324A 2019-04-05 2019-06-03 개선된 크레아티닌 측정 정확도를 위한 조성물과 방법, 및 그것의 사용 Active KR102574622B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962830191P 2019-04-05 2019-04-05
US62/830,191 2019-04-05
PCT/US2019/035155 WO2020204974A1 (en) 2019-04-05 2019-06-03 Compositions and methods for improved creatinine measurement accuracy and uses thereof

Publications (2)

Publication Number Publication Date
KR20210013626A KR20210013626A (ko) 2021-02-04
KR102574622B1 true KR102574622B1 (ko) 2023-09-06

Family

ID=67138031

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020207037324A Active KR102574622B1 (ko) 2019-04-05 2019-06-03 개선된 크레아티닌 측정 정확도를 위한 조성물과 방법, 및 그것의 사용
KR1020207037741A Active KR102937635B1 (ko) 2019-04-05 2019-06-03 크레아티닌/크레아틴 센서에 대한 교정 정확도 개선 방법
KR1020207037321A Active KR102480669B1 (ko) 2019-04-05 2019-06-03 크레아티닌/크레아틴 센서용 외부막 조성물
KR1020207037318A Active KR102519406B1 (ko) 2019-04-05 2019-06-03 우레아 바이오센서 및 실온에서의 우레아 바이오센서의 안정화
KR1020207037316A Active KR102519408B1 (ko) 2019-04-05 2019-06-03 다중 효소 바이오센서 및 실온에서의 다중 효소 바이오센서의 안정화

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020207037741A Active KR102937635B1 (ko) 2019-04-05 2019-06-03 크레아티닌/크레아틴 센서에 대한 교정 정확도 개선 방법
KR1020207037321A Active KR102480669B1 (ko) 2019-04-05 2019-06-03 크레아티닌/크레아틴 센서용 외부막 조성물
KR1020207037318A Active KR102519406B1 (ko) 2019-04-05 2019-06-03 우레아 바이오센서 및 실온에서의 우레아 바이오센서의 안정화
KR1020207037316A Active KR102519408B1 (ko) 2019-04-05 2019-06-03 다중 효소 바이오센서 및 실온에서의 다중 효소 바이오센서의 안정화

Country Status (10)

Country Link
US (6) US11761921B2 (enExample)
EP (5) EP3946697B1 (enExample)
JP (6) JP7100162B2 (enExample)
KR (5) KR102574622B1 (enExample)
CN (6) CN112534058B (enExample)
AU (3) AU2019439424B2 (enExample)
CA (3) CA3104896A1 (enExample)
DK (2) DK3947708T3 (enExample)
ES (1) ES3038379T3 (enExample)
WO (5) WO2020204973A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7100162B2 (ja) * 2019-04-05 2022-07-12 インストゥルメンテーション ラボラトリー カンパニー 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用
US12139741B2 (en) 2019-10-25 2024-11-12 Instrumentation Laboratory Company Biocide compositions compatible with enzyme biosensors and methods of use thereof
US12298268B2 (en) * 2020-05-21 2025-05-13 Nova Biomedical Corporation Single-use disposable reference sensor
WO2023015187A1 (en) * 2021-08-03 2023-02-09 Polymer Technology Systems, Inc. Systems and methods for quantifying the specific activity of creatininase
EP4476537B1 (en) 2022-02-09 2025-10-29 Instrumentation Laboratory Company Sensor for measuring ionized magnesium
CN114705674B (zh) * 2022-05-10 2025-07-22 光景生物科技(苏州)有限公司 一种全血中肌酸和肌酐的定量检测方法
AU2024316973A1 (en) * 2023-07-31 2026-01-22 Abbott Diabetes Care Inc. Background interference mitigation for high sensitivity creatinine sensing
KR102800865B1 (ko) 2024-07-31 2025-05-07 전남대학교 산학협력단 신규한 크레아티닌 정량 장치

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040256227A1 (en) 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
WO2005052596A1 (en) 2003-11-28 2005-06-09 Radiometer Medical Aps A reference solution
WO2008028011A2 (en) 2006-08-31 2008-03-06 Nanogen Inc. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US20080173064A1 (en) 2000-08-11 2008-07-24 Roche Diagnostics Operations, Inc. Creatinine Sensor Calibration
WO2009082699A1 (en) 2007-12-20 2009-07-02 I-Stat Corporation Compositions for forming immobiized biological layers for sensing
WO2016096725A1 (en) * 2014-12-18 2016-06-23 Radiometer Medical Aps Method for calibrating a device for measuring the concentration of creatinine

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5861459A (ja) * 1981-10-07 1983-04-12 Hitachi Ltd クレアチンとクレアチニンの分析装置
JPS6475000A (en) 1987-09-14 1989-03-20 Shimadzu Corp Method and equipment for analyzing creatinine
US5464747A (en) * 1993-10-29 1995-11-07 Boehringer Mannheim Corporation Oxidation-resistant muteins of β-galactosidase fragments
EP0944731B1 (en) * 1996-11-14 2006-01-18 Radiometer Medical ApS Enzyme sensor
DE69810194T2 (de) * 1997-06-03 2003-11-20 Matsushita Electric Industrial Co. Ltd., Osaka Cholesterinsensor
JP3635263B2 (ja) 2000-03-01 2005-04-06 ラジオメーター・メディカル・アクティーゼルスカブ 固体状態参照系を持つ電極デバイス
AT408662B (de) * 2000-05-16 2002-02-25 Hoffmann La Roche Creatinin-sensor
US6960466B2 (en) 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6872297B2 (en) * 2001-05-31 2005-03-29 Instrumentation Laboratory Company Analytical instruments, biosensors and methods thereof
US6767441B1 (en) 2001-07-31 2004-07-27 Nova Biomedical Corporation Biosensor with peroxidase enzyme
ES2355333T3 (es) * 2001-08-22 2011-03-24 Instrumentation Laboratory Company Método y aparato para calibrar sensores .
AU2002321531B2 (en) 2001-08-24 2007-12-13 Sensortec Limited Methods for producing highly sensitive potentiometric sensors
US7285198B2 (en) 2004-02-23 2007-10-23 Mysticmd, Inc. Strip electrode with conductive nano tube printing
GB0227424D0 (en) * 2002-11-25 2002-12-31 Univ Warwick Coatings
EP1679508B1 (en) 2003-10-30 2010-07-21 Arkray, Inc. Biosensor and method for preparation thereof
US7699964B2 (en) * 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US7946984B2 (en) * 2004-07-13 2011-05-24 Dexcom, Inc. Transcutaneous analyte sensor
EP1885870A1 (en) 2005-05-17 2008-02-13 Radiometer Medical ApS Enzyme sensor including a water-containing spacer layer
CN102608176B (zh) 2005-05-17 2016-08-10 雷迪奥米特医学公司 用二价锰离子溶液稳定或再活化肌酸酐传感器的方法
WO2006122552A1 (en) 2005-05-17 2006-11-23 Radiometer Medical Aps Method of stabilising or reactivating a creatinine sensor with a solution of a divalent manganese ion
US7959791B2 (en) 2005-05-17 2011-06-14 Radiometer Medical Aps Enzyme sensor with a cover membrane layer covered by a hydrophilic polymer
KR100726963B1 (ko) * 2005-06-15 2007-06-14 김경훈 바이오센서용 우레아제 고정화막의 제조 방법
US7799195B2 (en) * 2005-09-02 2010-09-21 Vladislav Dolnik Neutral polysaccharide wall coating for electrophoretic separations in capillaries and microchannels
US8617366B2 (en) * 2005-12-12 2013-12-31 Nova Biomedical Corporation Disposable urea sensor and system for determining creatinine and urea nitrogen-to-creatinine ratio in a single device
US9556471B2 (en) * 2006-08-09 2017-01-31 Flir Detection, Inc. Enzyme containing liquid and delivery system for detection of analytes on surfaces
IES20070774A2 (en) 2007-10-24 2008-12-24 Nat Univ Ireland Maynooth Monitoring target endogenous species in the brain
WO2011037702A1 (en) 2009-09-24 2011-03-31 Fresenius Medical Care Holdings, Inc. Amperometric creatinine biosensor with immobilized enzyme-polymer composition and systems using same, and methods
US9233788B2 (en) 2010-01-22 2016-01-12 Bayer Healthcare Llc Biosensor desiccant system having enhanced measurement performance
JP2014153243A (ja) 2013-02-12 2014-08-25 Tanita Corp バイオセンサおよびこれを用いた測定方法
EP2972275B1 (en) 2013-03-14 2019-07-10 Instrumentation Laboratory Company Whole blood hemolysis sensor
US9487811B2 (en) * 2013-03-15 2016-11-08 Abbott Point Of Care Inc. Biosensor structures for improved point of care testing and methods of manufacture thereof
WO2016096683A1 (en) 2014-12-18 2016-06-23 Radiometer Medical Calibration concept for amperometric creatinine sensor correcting for endogenous modulators
DK3234564T3 (da) 2014-12-18 2025-02-10 Radiometer Medical Aps Fremgangsmåde til kalibrering af en indretning til måling af koncentrationen af kreatinin
CN108291889B (zh) 2015-11-27 2021-03-12 雷迪奥米特医学公司 用于酶传感器的外层
JP7011906B2 (ja) 2017-08-25 2022-01-27 国立大学法人 筑波大学 クレアチニンセンサ
EP3676306B1 (en) 2017-08-28 2022-05-25 DSM IP Assets B.V. Synthetic membrane composition comprising polyurethane blend
JP7100162B2 (ja) 2019-04-05 2022-07-12 インストゥルメンテーション ラボラトリー カンパニー 改善されたクレアチニン測定精度のための組成物及び方法並びにこれらの使用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080173064A1 (en) 2000-08-11 2008-07-24 Roche Diagnostics Operations, Inc. Creatinine Sensor Calibration
US20040256227A1 (en) 2003-02-11 2004-12-23 Jungwon Shin Electrochemical urea sensors and methods of making the same
WO2005052596A1 (en) 2003-11-28 2005-06-09 Radiometer Medical Aps A reference solution
WO2008028011A2 (en) 2006-08-31 2008-03-06 Nanogen Inc. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
WO2009082699A1 (en) 2007-12-20 2009-07-02 I-Stat Corporation Compositions for forming immobiized biological layers for sensing
WO2016096725A1 (en) * 2014-12-18 2016-06-23 Radiometer Medical Aps Method for calibrating a device for measuring the concentration of creatinine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J Clin Lab Anal,26(1):22-34. (2014.05.15.)
Microelectron Eng,187:43-49 (2017.12.02.)

Also Published As

Publication number Publication date
CN112534059B (zh) 2025-01-07
ES3038379T3 (en) 2025-10-13
WO2020204975A1 (en) 2020-10-08
US12529673B2 (en) 2026-01-20
KR102519406B1 (ko) 2023-04-10
JP2021527224A (ja) 2021-10-11
EP3947711B1 (en) 2023-12-20
KR20210013625A (ko) 2021-02-04
US20220187234A1 (en) 2022-06-16
WO2020204972A1 (en) 2020-10-08
CN112424369A (zh) 2021-02-26
US20200319134A1 (en) 2020-10-08
WO2020204973A1 (en) 2020-10-08
CN112534058A (zh) 2021-03-19
KR20210014667A (ko) 2021-02-09
EP3947708B1 (en) 2024-02-14
JP7127159B2 (ja) 2022-08-29
US11327042B2 (en) 2022-05-10
DK3947708T3 (da) 2024-03-11
JP2021524587A (ja) 2021-09-13
US20200319136A1 (en) 2020-10-08
DK3947711T3 (da) 2024-01-15
AU2019439465A1 (en) 2021-05-20
CA3104896A1 (en) 2020-10-08
KR20210149577A (ko) 2021-12-09
CN112534058B (zh) 2024-12-27
CA3105013C (en) 2023-03-28
JP7100162B2 (ja) 2022-07-12
US11761921B2 (en) 2023-09-19
CA3105191A1 (en) 2020-10-08
CA3105013A1 (en) 2020-10-08
US20200319210A1 (en) 2020-10-08
EP3946697B1 (en) 2025-08-06
JP2021527194A (ja) 2021-10-11
EP3946697A1 (en) 2022-02-09
JP7015401B2 (ja) 2022-02-02
KR102937635B1 (ko) 2026-03-12
US20200318152A1 (en) 2020-10-08
CN112534059A (zh) 2021-03-19
EP3947709A1 (en) 2022-02-09
US20200319211A1 (en) 2020-10-08
JP7082691B2 (ja) 2022-06-08
CA3101513A1 (en) 2020-10-08
AU2019439424B2 (en) 2022-10-13
EP3946697C0 (en) 2025-08-06
KR20210013626A (ko) 2021-02-04
CN112638513A (zh) 2021-04-09
KR102480669B1 (ko) 2022-12-26
WO2020204976A1 (en) 2020-10-08
EP3947710A1 (en) 2022-02-09
CA3105011A1 (en) 2020-10-08
EP3947711A1 (en) 2022-02-09
KR102519408B1 (ko) 2023-04-10
US11460431B2 (en) 2022-10-04
AU2019440163A1 (en) 2021-01-07
US11293890B2 (en) 2022-04-05
JP2021528640A (ja) 2021-10-21
CN119776481A (zh) 2025-04-08
WO2020204974A1 (en) 2020-10-08
CN112513285A (zh) 2021-03-16
AU2019439465B2 (en) 2025-01-02
JP7135121B2 (ja) 2022-09-12
CN112513285B (zh) 2024-06-25
KR20210014666A (ko) 2021-02-09
JP2022068299A (ja) 2022-05-09
AU2019439424A1 (en) 2021-01-07
JP2021525888A (ja) 2021-09-27
AU2019440163B2 (en) 2022-01-27
EP3947708A1 (en) 2022-02-09

Similar Documents

Publication Publication Date Title
AU2024205186A1 (en) Spatial separation of particules in a particle containing solution for biomedical sensing and detection
CN112534059B (zh) 用于改进的肌酸酐测量准确度的组合物和方法及其用途
Ellison et al. Routes to improving the reliability of low level DNA analysis using real-time PCR
Johnson et al. Real-time quantitative PCR, pathogen detection and MIQE
US20190041411A1 (en) Automated on-instrument ph adjustment
Zhou et al. A SARS-CoV‑2 Reference Standard Quantified by Multiple Digital PCR Platforms for Quality Assessment of Molecular Tests
Talhouk et al. Single-patient molecular testing with NanoString nCounter data using a reference-based strategy for batch effect correction
Bénard et al. Measurement of enzyme activities and optimization of continuous and discontinuous assays
Luo et al. Multiplex digital nucleic acid analysis by a LAMP–argonaute coupling assay via a parallel droplet fusion SlipChip
Jing et al. Reference materials for molecular diagnostics: Current achievements and future strategies
Karthikeyan et al. Inorganic-organic composite matrix for the enzymatic detection of phosphate in food samples
Li et al. CRISPR-SDA: an integrated isothermal amplification and CRISPR-Cas12a biosensing platform for sensitive detection of microRNA-21
CA3105011C (en) Compositions and methods for improved creatinine measurement accuracy and uses thereof
Suzuki et al. Microfabricated flow system for ammonia and creatinine with an air-gap structure
Argyropoulos et al. Modeling bias and variation in the stochastic processes of small RNA sequencing
CA3101513C (en) Improved calibration accuracy method for creatinine/creatine sensors
Nagaraja et al. Development of quantitative enzymatic method and its validation for the assay of glucose in human serum
LU603644B1 (en) Self-calibrating dual-signal biosensor and its application in mirna detection
Khidir et al. Effect of Increasing Glucose Concentration on Estimation of Electrolytes by ion selective electrode
Cervera et al. New Chemistry Cartridge for the GEM Premier 4000 Critical Care Analyzer, Including Electrochemical Sensors for Creatinine, Urea, and Measured Bicarbonate
Apostolopoulos Conclusion: Build Stronger Assays by Addressing Core Development Challenges
Lê Best Practice# 1: Optimize Adapter Ligation Conditions

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20201224

Patent event code: PA01051R01D

Comment text: International Patent Application

PA0201 Request for examination
PG1501 Laying open of application
E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20220927

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20230329

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20230823

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20230831

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20230901

End annual number: 3

Start annual number: 1

PG1601 Publication of registration