CA3080763A1 - Synthesis of boronate ester derivatives and uses thereof - Google Patents
Synthesis of boronate ester derivatives and uses thereof Download PDFInfo
- Publication number
- CA3080763A1 CA3080763A1 CA3080763A CA3080763A CA3080763A1 CA 3080763 A1 CA3080763 A1 CA 3080763A1 CA 3080763 A CA3080763 A CA 3080763A CA 3080763 A CA3080763 A CA 3080763A CA 3080763 A1 CA3080763 A1 CA 3080763A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- optionally substituted
- formula
- group
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
- B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
- B01J23/46—Ruthenium, rhodium, osmium or iridium
- B01J23/462—Ruthenium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762580343P | 2017-11-01 | 2017-11-01 | |
| US62/580,343 | 2017-11-01 | ||
| PCT/US2018/058143 WO2019089542A1 (en) | 2017-11-01 | 2018-10-30 | Synthesis of boronate ester derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3080763A1 true CA3080763A1 (en) | 2019-05-09 |
Family
ID=66245250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3080763A Pending CA3080763A1 (en) | 2017-11-01 | 2018-10-30 | Synthesis of boronate ester derivatives and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11999757B2 (enExample) |
| EP (1) | EP3704130A4 (enExample) |
| JP (1) | JP7480050B2 (enExample) |
| KR (1) | KR20200076730A (enExample) |
| CN (2) | CN111556872B (enExample) |
| AU (1) | AU2018360502B2 (enExample) |
| CA (1) | CA3080763A1 (enExample) |
| CL (1) | CL2020001143A1 (enExample) |
| CO (1) | CO2020006299A2 (enExample) |
| JO (1) | JOP20200101A1 (enExample) |
| MX (2) | MX2020004425A (enExample) |
| PH (1) | PH12020550544A1 (enExample) |
| SG (1) | SG11202003762VA (enExample) |
| WO (1) | WO2019089542A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3080763A1 (en) | 2017-11-01 | 2019-05-09 | Melinta Therapeutics, Inc. | Synthesis of boronate ester derivatives and uses thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| JP2852545B2 (ja) | 1989-11-14 | 1999-02-03 | チッソ株式会社 | 複数の不斉点を持つ光学活性化合物および製造法 |
| CA2165996C (en) | 1995-12-22 | 2002-01-29 | Murray Douglas Bailey | Stereoselective preparation of 2-substituted succinic derivatives |
| FR2745288B1 (fr) | 1996-02-27 | 1998-04-17 | Adir | Nouveaux derives de l'acide boronique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19917979A1 (de) | 1999-04-21 | 2000-10-26 | Clariant Gmbh | Verfahren zur Herstellung von substituierten Phenyl-boronsäuren |
| USRE39333E1 (en) | 1999-06-04 | 2006-10-10 | Kaneka Corporation | Process for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives |
| DE10032017A1 (de) | 2000-07-01 | 2002-01-10 | Clariant Gmbh | Verfahren zur Herstellung hochreiner Formylphenylboronsäuren |
| DE10112401A1 (de) * | 2001-03-13 | 2002-09-19 | Degussa | Alkohol-Dehydrogenase und deren Verwendung |
| DE10119274A1 (de) * | 2001-04-20 | 2002-10-31 | Juelich Enzyme Products Gmbh | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
| JP4824874B2 (ja) * | 2001-07-19 | 2011-11-30 | 高砂香料工業株式会社 | 光学活性γ−ブチロラクトンの製造方法 |
| ES2544579T3 (es) * | 2002-07-30 | 2015-09-01 | Takasago International Corporation | Procedimiento de producción de un beta-aminoácido ópticamente activo |
| TWI372725B (en) | 2004-01-30 | 2012-09-21 | Semequip Inc | Methods of synthesis of isotopically enriched borohydride and methods of synthesis of isotopically enriched boranes |
| DE102004022397A1 (de) * | 2004-05-06 | 2005-12-01 | Consortium für elektrochemische Industrie GmbH | Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen |
| WO2007034909A1 (ja) * | 2005-09-22 | 2007-03-29 | Kaneka Corporation | （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法 |
| GB2474687A (en) | 2009-10-23 | 2011-04-27 | Phoenix Chemicals Ltd | A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives) |
| HUE048859T2 (hu) * | 2010-08-10 | 2020-08-28 | Rempex Pharmaceuticals Inc | Gyûrûs bórsavészter származékok, eljárás elõállításukra, és terápiás alkalmazásuk |
| WO2013056163A1 (en) * | 2011-10-14 | 2013-04-18 | The Regents Of The University Of California | Beta-lactamase inhibitors |
| US20150119363A1 (en) * | 2012-02-15 | 2015-04-30 | Rempex Pharmaceuticals, Inc.. | Methods of treating bacterial infections |
| US20150105562A1 (en) | 2012-08-20 | 2015-04-16 | Manac Inc. | Method for preparing borinic acid derivatives and novel borinic acid derivatives |
| CN102965403A (zh) | 2012-11-19 | 2013-03-13 | 苏州汉酶生物技术有限公司 | (3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的生物制备方法 |
| KR102147420B1 (ko) | 2012-12-07 | 2020-08-25 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| LT3066071T (lt) | 2013-11-05 | 2018-09-10 | Bracco Imaging S.P.A. | Jopamidolio gamybos būdas |
| ES2750805T3 (es) | 2014-05-05 | 2020-03-27 | Rempex Pharmaceuticals Inc | Síntesis de sales de boronato y usos de las mismas |
| CA3080763A1 (en) | 2017-11-01 | 2019-05-09 | Melinta Therapeutics, Inc. | Synthesis of boronate ester derivatives and uses thereof |
-
2018
- 2018-10-30 CA CA3080763A patent/CA3080763A1/en active Pending
- 2018-10-30 AU AU2018360502A patent/AU2018360502B2/en active Active
- 2018-10-30 JO JOP/2020/0101A patent/JOP20200101A1/ar unknown
- 2018-10-30 JP JP2020543266A patent/JP7480050B2/ja active Active
- 2018-10-30 EP EP18874877.6A patent/EP3704130A4/en active Pending
- 2018-10-30 CN CN201880079247.3A patent/CN111556872B/zh active Active
- 2018-10-30 SG SG11202003762VA patent/SG11202003762VA/en unknown
- 2018-10-30 MX MX2020004425A patent/MX2020004425A/es unknown
- 2018-10-30 WO PCT/US2018/058143 patent/WO2019089542A1/en not_active Ceased
- 2018-10-30 CN CN202410485244.7A patent/CN118388347A/zh active Pending
- 2018-10-30 US US16/760,369 patent/US11999757B2/en active Active
- 2018-10-30 KR KR1020207015638A patent/KR20200076730A/ko not_active Ceased
- 2018-10-31 US US16/176,302 patent/US20190127396A1/en not_active Abandoned
-
2020
- 2020-04-30 CL CL2020001143A patent/CL2020001143A1/es unknown
- 2020-05-01 PH PH12020550544A patent/PH12020550544A1/en unknown
- 2020-05-26 CO CONC2020/0006299A patent/CO2020006299A2/es unknown
- 2020-07-13 MX MX2023000529A patent/MX2023000529A/es unknown
-
2024
- 2024-04-04 US US18/627,105 patent/US20240279248A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20190127396A1 (en) | 2019-05-02 |
| CN111556872A (zh) | 2020-08-18 |
| KR20200076730A (ko) | 2020-06-29 |
| MX2020004425A (es) | 2020-08-06 |
| CN111556872B (zh) | 2024-05-10 |
| SG11202003762VA (en) | 2020-05-28 |
| US20200308197A1 (en) | 2020-10-01 |
| JOP20200101A1 (ar) | 2022-10-30 |
| EP3704130A1 (en) | 2020-09-09 |
| CN118388347A (zh) | 2024-07-26 |
| CL2020001143A1 (es) | 2020-10-30 |
| JP2021501205A (ja) | 2021-01-14 |
| WO2019089542A1 (en) | 2019-05-09 |
| AU2018360502B2 (en) | 2024-05-02 |
| CO2020006299A2 (es) | 2020-06-09 |
| US20240279248A1 (en) | 2024-08-22 |
| BR112020008498A2 (pt) | 2020-10-20 |
| MX2023000529A (es) | 2023-02-13 |
| US11999757B2 (en) | 2024-06-04 |
| JP7480050B2 (ja) | 2024-05-09 |
| AU2018360502A1 (en) | 2020-06-04 |
| EP3704130A4 (en) | 2021-07-07 |
| PH12020550544A1 (en) | 2021-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220929 |
|
| EEER | Examination request |
Effective date: 20220929 |
|
| EEER | Examination request |
Effective date: 20220929 |