CA3070100A1 - Regions de liaison a un antigene dirigees contre les domaines de la fibronectine de type iii et leurs procedes d'utilisation - Google Patents
Regions de liaison a un antigene dirigees contre les domaines de la fibronectine de type iii et leurs procedes d'utilisation Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne des anticorps des domaines de la fibronectine de type III (FN3), des polynucléotides pouvant coder pour les anticorps des domaines FN3 ou les fragments de liaison à un antigène, des cellules exprimant les anticorps du domaine FN3 ou les fragments de liaison à un antigène, ainsi que des vecteurs associés et des anticorps du domaine FN3 ou des fragments de liaison à un antigène marqués de manière détectable pouvant être utilisés pour concevoir des récepteurs d'antigènes chimériques (CAR) ciblant le domaine FN3. Les procédés permettant de produire les anticorps des domaines FN3, les CAR et les cellules immunitaires modifiées, et les procédés d'utilisation des cellules immunitaires modifiées peuvent être appliqués pour traiter des maladies, dont le cancer.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762533341P | 2017-07-17 | 2017-07-17 | |
| US62/533,341 | 2017-07-17 | ||
| US201862625576P | 2018-02-02 | 2018-02-02 | |
| US62/625,576 | 2018-02-02 | ||
| PCT/US2018/042495 WO2019018402A2 (fr) | 2017-07-17 | 2018-07-17 | Régions de liaison à un antigène dirigées contre les domaines de la fibronectine de type iii et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3070100A1 true CA3070100A1 (fr) | 2019-01-24 |
Family
ID=65000212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3070100A Pending CA3070100A1 (fr) | 2017-07-17 | 2018-07-17 | Regions de liaison a un antigene dirigees contre les domaines de la fibronectine de type iii et leurs procedes d'utilisation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11161897B2 (fr) |
| EP (1) | EP3655026A4 (fr) |
| JP (1) | JP7280238B2 (fr) |
| KR (1) | KR20200028447A (fr) |
| CN (1) | CN111093696B (fr) |
| AU (1) | AU2018304173A1 (fr) |
| CA (1) | CA3070100A1 (fr) |
| IL (1) | IL271982A (fr) |
| MA (1) | MA49652A (fr) |
| MX (1) | MX2020000595A (fr) |
| WO (1) | WO2019018402A2 (fr) |
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| TW202118792A (zh) * | 2019-07-26 | 2021-05-16 | 美商健生生物科技公司 | 抗hk2嵌合抗原受體(car) |
| JP2022551204A (ja) * | 2019-10-14 | 2022-12-07 | アロ・バイオセラピューティクス・カンパニー | Ｃｄ７１結合フィブロネクチンｉｉｉ型ドメイン |
| WO2021087356A1 (fr) * | 2019-11-01 | 2021-05-06 | The Trustees Of The University Of Pennsylvania | Récepteurs d'antigènes chimériques ciblant la fibronectine (car) |
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| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
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| DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
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| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
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| AR094271A1 (es) | 2012-12-21 | 2015-07-22 | Aveo Pharmaceuticals Inc | Anticuerpos anti-gdf15 |
| EP3744736A1 (fr) | 2013-02-20 | 2020-12-02 | Novartis AG | Ciblage efficace de la leucémie primaire humaine au moyen de lymphocytes t génétiquement modifiés des récepteurs d'antigènes chimériques anti-cd123 |
| US9790282B2 (en) * | 2013-03-25 | 2017-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-CD276 polypeptides, proteins, and chimeric antigen receptors |
| KR102220382B1 (ko) | 2013-05-13 | 2021-02-25 | 셀렉티스 | 면역요법을 위한 매우 활성인 ｔ 세포를 조작하는 방법 |
| LT3546572T (lt) | 2013-05-13 | 2024-05-27 | Cellectis | Cd19 specifinis chimerinis antigeno receptorius ir jo panaudojimas |
| US9890393B2 (en) | 2013-05-29 | 2018-02-13 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system |
| RU2694659C2 (ru) | 2014-01-06 | 2019-07-16 | Ф. Хоффманн-Ля Рош Аг | Одновалентные модули-переносчики через гематоэнцефалический барьер |
| HUE054588T2 (hu) * | 2014-04-07 | 2021-09-28 | Novartis Ag | Rák kezelése CD19 elleni, kiméra antigénreceptor alkalmazásával |
| PT3653221T (pt) | 2015-02-19 | 2022-11-08 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
| SI3280729T1 (sl) * | 2015-04-08 | 2022-09-30 | Novartis Ag | Terapije CD20, terapije CD22 in kombinacija terapij s celico, ki izraža himerni antigenski receptor CD19 (CAR) |
| BR112017023798A2 (pt) * | 2015-05-06 | 2018-10-16 | Janssen Biotech Inc | domínios fibronectina tipo iii de ligação a antígeno prostático específico de membrana |
| TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Ｔｉｇｉｔ結合劑和彼之用途 |
| EP3318577A4 (fr) * | 2015-06-30 | 2019-01-23 | Osaka University | Anticorps agoniste d'antiplexine a1 |
| US11078286B2 (en) | 2015-09-20 | 2021-08-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies specific for fibroblast growth factor receptor 4 (FGFR4) and methods of their use |
| MY187325A (en) * | 2015-11-24 | 2021-09-22 | Byondis Bv | Anti-5t4 antibodies and antibody-drug conjugates |
| EP3401336A4 (fr) * | 2016-01-05 | 2020-01-22 | Jiangsu Hengrui Medicine Co., Ltd. | Anticorps anti-pcsk9, fragment de liaison à l'antigène associé et application médicale associée |
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| JP2021506243A (ja) * | 2017-12-13 | 2021-02-22 | ヤンセン バイオテツク，インコーポレーテツド | Ｔ細胞受容体及びβ２ミクログロブリン発現を排除するように遺伝子改変された不死化ＣＡＲ−Ｔ細胞 |
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2018
- 2018-07-17 US US16/037,340 patent/US11161897B2/en active Active
- 2018-07-17 EP EP18835568.9A patent/EP3655026A4/fr active Pending
- 2018-07-17 CN CN201880060303.9A patent/CN111093696B/zh active Active
- 2018-07-17 AU AU2018304173A patent/AU2018304173A1/en active Pending
- 2018-07-17 KR KR1020207004214A patent/KR20200028447A/ko not_active Application Discontinuation
- 2018-07-17 WO PCT/US2018/042495 patent/WO2019018402A2/fr unknown
- 2018-07-17 MA MA049652A patent/MA49652A/fr unknown
- 2018-07-17 MX MX2020000595A patent/MX2020000595A/es unknown
- 2018-07-17 JP JP2020502225A patent/JP7280238B2/ja active Active
- 2018-07-17 CA CA3070100A patent/CA3070100A1/fr active Pending
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2020
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2021
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| AU2018304173A1 (en) | 2020-01-30 |
| US11161897B2 (en) | 2021-11-02 |
| CN111093696A (zh) | 2020-05-01 |
| JP2020530766A (ja) | 2020-10-29 |
| MX2020000595A (es) | 2020-09-10 |
| US20190016789A1 (en) | 2019-01-17 |
| EP3655026A2 (fr) | 2020-05-27 |
| EP3655026A4 (fr) | 2021-07-28 |
| WO2019018402A3 (fr) | 2019-02-28 |
| MA49652A (fr) | 2020-05-27 |
| JP7280238B2 (ja) | 2023-05-23 |
| WO2019018402A2 (fr) | 2019-01-24 |
| CN111093696B (zh) | 2023-10-27 |
| KR20200028447A (ko) | 2020-03-16 |
| US20220127343A1 (en) | 2022-04-28 |
| IL271982A (en) | 2020-02-27 |
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