CA3070100A1 - Regions de liaison a un antigene dirigees contre les domaines de la fibronectine de type iii et leurs procedes d'utilisation - Google Patents
Regions de liaison a un antigene dirigees contre les domaines de la fibronectine de type iii et leurs procedes d'utilisation Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L'invention concerne des anticorps des domaines de la fibronectine de type III (FN3), des polynucléotides pouvant coder pour les anticorps des domaines FN3 ou les fragments de liaison à un antigène, des cellules exprimant les anticorps du domaine FN3 ou les fragments de liaison à un antigène, ainsi que des vecteurs associés et des anticorps du domaine FN3 ou des fragments de liaison à un antigène marqués de manière détectable pouvant être utilisés pour concevoir des récepteurs d'antigènes chimériques (CAR) ciblant le domaine FN3. Les procédés permettant de produire les anticorps des domaines FN3, les CAR et les cellules immunitaires modifiées, et les procédés d'utilisation des cellules immunitaires modifiées peuvent être appliqués pour traiter des maladies, dont le cancer.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762533341P | 2017-07-17 | 2017-07-17 | |
| US62/533,341 | 2017-07-17 | ||
| US201862625576P | 2018-02-02 | 2018-02-02 | |
| US62/625,576 | 2018-02-02 | ||
| PCT/US2018/042495 WO2019018402A2 (fr) | 2017-07-17 | 2018-07-17 | Régions de liaison à un antigène dirigées contre les domaines de la fibronectine de type iii et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3070100A1 true CA3070100A1 (fr) | 2019-01-24 |
Family
ID=65000212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3070100A Pending CA3070100A1 (fr) | 2017-07-17 | 2018-07-17 | Regions de liaison a un antigene dirigees contre les domaines de la fibronectine de type iii et leurs procedes d'utilisation |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11161897B2 (fr) |
| EP (1) | EP3655026A4 (fr) |
| JP (1) | JP7280238B2 (fr) |
| KR (1) | KR20200028447A (fr) |
| CN (1) | CN111093696B (fr) |
| AU (1) | AU2018304173A1 (fr) |
| CA (1) | CA3070100A1 (fr) |
| IL (1) | IL271982B1 (fr) |
| MA (1) | MA49652A (fr) |
| MX (1) | MX2020000595A (fr) |
| WO (1) | WO2019018402A2 (fr) |
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|---|---|---|---|---|
| UY38800A (es) | 2019-07-26 | 2021-01-29 | Janssen Biotech Inc | Receptor de antígeno quimérico (car) anti-hk2 |
| WO2021076546A1 (fr) * | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Domaines de type iii de fibronectine de liaison à cd137 |
| WO2021087356A1 (fr) * | 2019-11-01 | 2021-05-06 | The Trustees Of The University Of Pennsylvania | Récepteurs d'antigènes chimériques ciblant la fibronectine (car) |
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| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| EP0435911B1 (fr) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Milieu de culture de cellules pour l'amelioration de la croissance des cellules, de la longivite de la culture et de l'expression du produit |
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| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
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| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
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| EA038645B1 (ru) * | 2012-12-21 | 2021-09-28 | Авео Фармасьютикалз, Инк. | Антитела к gdf15 |
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| WO2014160627A1 (fr) * | 2013-03-25 | 2014-10-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polypeptides anti-cd276, protéines, et récepteurs d'antigènes chimériques |
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| PL2997141T3 (pl) | 2013-05-13 | 2023-02-06 | Cellectis | Chimeryczny receptor antygenowy swoisty względem cd19 i jego zastosowania |
| EP3004337B1 (fr) | 2013-05-29 | 2017-08-02 | Cellectis | Procédé de manipulation de cellules t pour l'immunothérapie au moyen d'un système de nucléase cas guidé par l'arn |
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-
2018
- 2018-07-17 EP EP18835568.9A patent/EP3655026A4/fr active Pending
- 2018-07-17 AU AU2018304173A patent/AU2018304173A1/en active Pending
- 2018-07-17 MA MA049652A patent/MA49652A/fr unknown
- 2018-07-17 CA CA3070100A patent/CA3070100A1/fr active Pending
- 2018-07-17 KR KR1020207004214A patent/KR20200028447A/ko not_active Application Discontinuation
- 2018-07-17 JP JP2020502225A patent/JP7280238B2/ja active Active
- 2018-07-17 WO PCT/US2018/042495 patent/WO2019018402A2/fr unknown
- 2018-07-17 US US16/037,340 patent/US11161897B2/en active Active
- 2018-07-17 CN CN201880060303.9A patent/CN111093696B/zh active Active
- 2018-07-17 MX MX2020000595A patent/MX2020000595A/es unknown
- 2018-07-17 IL IL271982A patent/IL271982B1/en unknown
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2021
- 2021-10-04 US US17/493,032 patent/US20220127343A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL271982A (en) | 2020-02-27 |
| MX2020000595A (es) | 2020-09-10 |
| EP3655026A4 (fr) | 2021-07-28 |
| KR20200028447A (ko) | 2020-03-16 |
| US20190016789A1 (en) | 2019-01-17 |
| IL271982B1 (en) | 2024-10-01 |
| WO2019018402A2 (fr) | 2019-01-24 |
| JP7280238B2 (ja) | 2023-05-23 |
| MA49652A (fr) | 2020-05-27 |
| CN111093696A (zh) | 2020-05-01 |
| AU2018304173A1 (en) | 2020-01-30 |
| US11161897B2 (en) | 2021-11-02 |
| WO2019018402A3 (fr) | 2019-02-28 |
| US20220127343A1 (en) | 2022-04-28 |
| CN111093696B (zh) | 2023-10-27 |
| EP3655026A2 (fr) | 2020-05-27 |
| JP2020530766A (ja) | 2020-10-29 |
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