CA3047288A1 - Thiazine derivatives as beta-secretase inhibitors and methods of use - Google Patents

Thiazine derivatives as beta-secretase inhibitors and methods of use Download PDF

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Publication number
CA3047288A1
CA3047288A1 CA3047288A CA3047288A CA3047288A1 CA 3047288 A1 CA3047288 A1 CA 3047288A1 CA 3047288 A CA3047288 A CA 3047288A CA 3047288 A CA3047288 A CA 3047288A CA 3047288 A1 CA3047288 A1 CA 3047288A1
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CA
Canada
Prior art keywords
tautomer
compound
pharmaceutically acceptable
dihydro
acceptable salt
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CA3047288A
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English (en)
French (fr)
Inventor
Matthew P. Bourbeau
Paul E. Harrington
Qingyian Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
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Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA3047288A1 publication Critical patent/CA3047288A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CA3047288A 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use Pending CA3047288A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434714P 2016-12-15 2016-12-15
US62/434,714 2016-12-15
PCT/US2017/066179 WO2018112083A1 (en) 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use

Publications (1)

Publication Number Publication Date
CA3047288A1 true CA3047288A1 (en) 2018-06-21

Family

ID=60888745

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3047288A Pending CA3047288A1 (en) 2016-12-15 2017-12-13 Thiazine derivatives as beta-secretase inhibitors and methods of use

Country Status (9)

Country Link
US (1) US10889579B2 (https=)
EP (1) EP3555084B1 (https=)
JP (1) JP7149272B2 (https=)
AU (1) AU2017376444B2 (https=)
CA (1) CA3047288A1 (https=)
ES (1) ES2910791T3 (https=)
MA (1) MA54100A (https=)
MX (1) MX388697B (https=)
WO (1) WO2018112083A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3555085B1 (en) 2016-12-15 2020-12-02 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
JP7149271B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としての１，４－チアジンジオキシドおよび１，２，４－チアジアジンジオキシド誘導体ならびに使用方法
WO2018112084A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
US10947223B2 (en) 2016-12-15 2021-03-16 Amgen Inc. Substituted oxazines as beta-secretase inhibitors
JP7149272B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法

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Publication number Publication date
ES2910791T3 (es) 2022-05-13
MX388697B (es) 2025-03-20
MA54100A (fr) 2021-10-20
US20200062743A1 (en) 2020-02-27
JP2020503292A (ja) 2020-01-30
AU2017376444B2 (en) 2021-09-30
EP3555084A1 (en) 2019-10-23
JP7149272B2 (ja) 2022-10-06
WO2018112083A1 (en) 2018-06-21
AU2017376444A1 (en) 2019-07-04
US10889579B2 (en) 2021-01-12
MX2019007102A (es) 2019-12-16
EP3555084B1 (en) 2022-03-16

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