CA3039525A1 - Variant actriib proteins and uses thereof - Google Patents

Variant actriib proteins and uses thereof Download PDF

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Publication number
CA3039525A1
CA3039525A1 CA3039525A CA3039525A CA3039525A1 CA 3039525 A1 CA3039525 A1 CA 3039525A1 CA 3039525 A CA3039525 A CA 3039525A CA 3039525 A CA3039525 A CA 3039525A CA 3039525 A1 CA3039525 A1 CA 3039525A1
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CA
Canada
Prior art keywords
amino acid
polypeptide
seq
heteromultimer
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3039525A
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English (en)
French (fr)
Inventor
Ravindra Kumar
Asya Grinberg
Erik M. Vogan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acceleron Pharma Inc
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Acceleron Pharma Inc
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Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of CA3039525A1 publication Critical patent/CA3039525A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3039525A 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof Pending CA3039525A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404718P 2016-10-05 2016-10-05
US62/404,718 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

Publications (1)

Publication Number Publication Date
CA3039525A1 true CA3039525A1 (en) 2018-04-12

Family

ID=61831930

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3039525A Pending CA3039525A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

Country Status (10)

Country Link
US (2) US11267865B2 (enExample)
EP (1) EP3523328A4 (enExample)
JP (2) JP7280182B2 (enExample)
KR (2) KR102595559B1 (enExample)
CN (1) CN110036025B (enExample)
AU (3) AU2017338916B2 (enExample)
BR (1) BR112019006918A2 (enExample)
CA (1) CA3039525A1 (enExample)
MA (1) MA46471A (enExample)
WO (1) WO2018067874A1 (enExample)

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CA3043184A1 (en) 2016-11-10 2018-05-17 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
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Also Published As

Publication number Publication date
MA46471A (fr) 2021-05-19
KR102595559B1 (ko) 2023-10-30
US12240887B2 (en) 2025-03-04
AU2024200684A1 (en) 2024-02-22
KR20190073414A (ko) 2019-06-26
AU2017338916B2 (en) 2022-03-24
JP2023033573A (ja) 2023-03-10
CN110036025A (zh) 2019-07-19
KR102761094B1 (ko) 2025-02-03
JP2019536440A (ja) 2019-12-19
BR112019006918A2 (pt) 2019-06-25
US11267865B2 (en) 2022-03-08
CN110036025B (zh) 2024-03-22
AU2017338916A1 (en) 2019-04-18
EP3523328A1 (en) 2019-08-14
US20220306724A1 (en) 2022-09-29
WO2018067874A1 (en) 2018-04-12
KR20230152811A (ko) 2023-11-03
JP7617962B2 (ja) 2025-01-20
AU2022201698A1 (en) 2022-04-07
US20200055919A1 (en) 2020-02-20
JP7280182B2 (ja) 2023-05-23
EP3523328A4 (en) 2020-04-01

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