KR102595559B1 - 변이체 actriib 단백질 및 이의 용도 - Google Patents

변이체 actriib 단백질 및 이의 용도 Download PDF

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Publication number
KR102595559B1
KR102595559B1 KR1020197012902A KR20197012902A KR102595559B1 KR 102595559 B1 KR102595559 B1 KR 102595559B1 KR 1020197012902 A KR1020197012902 A KR 1020197012902A KR 20197012902 A KR20197012902 A KR 20197012902A KR 102595559 B1 KR102595559 B1 KR 102595559B1
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amino acid
seq
polypeptide
fusion protein
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KR20190073414A (ko
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라빈드라 쿠마르
이스야 그린버그
에릭 엠. 보간
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악셀레론 파마 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197012902A 2016-10-05 2017-10-05 변이체 actriib 단백질 및 이의 용도 Active KR102595559B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237036672A KR102761094B1 (ko) 2016-10-05 2017-10-05 변이체 actriib 단백질 및 이의 용도

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404718P 2016-10-05 2016-10-05
US62/404,718 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

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KR20190073414A KR20190073414A (ko) 2019-06-26
KR102595559B1 true KR102595559B1 (ko) 2023-10-30

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US (2) US11267865B2 (enExample)
EP (1) EP3523328A4 (enExample)
JP (2) JP7280182B2 (enExample)
KR (2) KR102595559B1 (enExample)
CN (1) CN110036025B (enExample)
AU (3) AU2017338916B2 (enExample)
BR (1) BR112019006918A2 (enExample)
CA (1) CA3039525A1 (enExample)
MA (1) MA46471A (enExample)
WO (1) WO2018067874A1 (enExample)

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AU2015358469B2 (en) 2014-12-03 2021-05-27 Acceleron Pharma Inc. Activin-ActRII antagonists and uses for treating anemia
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US20170306027A1 (en) 2016-04-06 2017-10-26 Acceleron Pharma Inc. Alk7 antagonists and uses thereof
CN110036025B (zh) 2016-10-05 2024-03-22 阿塞勒隆制药公司 变体ActRIIB蛋白及其用途
JOP20190085A1 (ar) 2016-10-20 2019-04-17 Biogen Ma Inc طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة
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JP7258021B2 (ja) 2017-11-09 2023-04-14 ケロス セラピューティクス インコーポレイテッド アクチビンＩＩａ型受容体変異体を含む医薬組成物
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CN109293763B (zh) * 2018-10-26 2021-10-26 中国农业科学院特产研究所 水貂激活素b蛋白及其制备与应用
JP2022549506A (ja) 2019-09-27 2022-11-25 ディスク・メディシン・インコーポレイテッド 骨髄線維症および関連状態を処置するための方法
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JP2023033573A (ja) 2023-03-10
BR112019006918A2 (pt) 2019-06-25
WO2018067874A1 (en) 2018-04-12
AU2017338916B2 (en) 2022-03-24
EP3523328A1 (en) 2019-08-14
US20200055919A1 (en) 2020-02-20
US11267865B2 (en) 2022-03-08
CA3039525A1 (en) 2018-04-12
CN110036025B (zh) 2024-03-22
KR20230152811A (ko) 2023-11-03
JP2019536440A (ja) 2019-12-19
AU2024200684A1 (en) 2024-02-22
AU2017338916A1 (en) 2019-04-18
EP3523328A4 (en) 2020-04-01
CN110036025A (zh) 2019-07-19
US12240887B2 (en) 2025-03-04
JP7280182B2 (ja) 2023-05-23
US20220306724A1 (en) 2022-09-29
KR102761094B1 (ko) 2025-02-03
JP7617962B2 (ja) 2025-01-20
AU2022201698A1 (en) 2022-04-07
MA46471A (fr) 2021-05-19
KR20190073414A (ko) 2019-06-26

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