JP7280182B2 - バリアントＡｃｔＲＩＩＢタンパク質およびその使用 - Google Patents

バリアントＡｃｔＲＩＩＢタンパク質およびその使用 Download PDF

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JP7280182B2
JP7280182B2 JP2019518302A JP2019518302A JP7280182B2 JP 7280182 B2 JP7280182 B2 JP 7280182B2 JP 2019518302 A JP2019518302 A JP 2019518302A JP 2019518302 A JP2019518302 A JP 2019518302A JP 7280182 B2 JP7280182 B2 JP 7280182B2
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amino acid
polypeptide
seq
actriib
acid sequence
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JP2019536440A (ja
JP2019536440A5 (enExample
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ラビンドラ クマール，
アシャ グリンバーグ，
エリック エム． ヴォガン，
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アクセルロン ファーマ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2019518302A 2016-10-05 2017-10-05 バリアントＡｃｔＲＩＩＢタンパク質およびその使用 Active JP7280182B2 (ja)

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JP2023006458A JP7617962B2 (ja) 2016-10-05 2023-01-19 バリアントＡｃｔＲＩＩＢタンパク質およびその使用

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US201662404718P 2016-10-05 2016-10-05
US62/404,718 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

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JP2019536440A JP2019536440A (ja) 2019-12-19
JP2019536440A5 JP2019536440A5 (enExample) 2020-11-12
JP7280182B2 true JP7280182B2 (ja) 2023-05-23

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US (2) US11267865B2 (enExample)
EP (1) EP3523328A4 (enExample)
JP (2) JP7280182B2 (enExample)
KR (2) KR102595559B1 (enExample)
CN (1) CN110036025B (enExample)
AU (3) AU2017338916B2 (enExample)
BR (1) BR112019006918A2 (enExample)
CA (1) CA3039525A1 (enExample)
MA (1) MA46471A (enExample)
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023033573A (ja) * 2016-10-05 2023-03-10 アクセルロン ファーマ インコーポレイテッド バリアントＡｃｔＲＩＩＢタンパク質およびその使用

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US20170306027A1 (en) 2016-04-06 2017-10-26 Acceleron Pharma Inc. Alk7 antagonists and uses thereof
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CA3043184A1 (en) 2016-11-10 2018-05-17 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
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US20240181007A1 (en) * 2021-01-08 2024-06-06 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
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JP2023033573A (ja) * 2016-10-05 2023-03-10 アクセルロン ファーマ インコーポレイテッド バリアントＡｃｔＲＩＩＢタンパク質およびその使用
JP7617962B2 (ja) 2016-10-05 2025-01-20 アクセルロン ファーマ インコーポレイテッド バリアントＡｃｔＲＩＩＢタンパク質およびその使用
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MA46471A (fr) 2021-05-19
KR102595559B1 (ko) 2023-10-30
US12240887B2 (en) 2025-03-04
AU2024200684A1 (en) 2024-02-22
KR20190073414A (ko) 2019-06-26
AU2017338916B2 (en) 2022-03-24
JP2023033573A (ja) 2023-03-10
CN110036025A (zh) 2019-07-19
KR102761094B1 (ko) 2025-02-03
JP2019536440A (ja) 2019-12-19
BR112019006918A2 (pt) 2019-06-25
US11267865B2 (en) 2022-03-08
CN110036025B (zh) 2024-03-22
AU2017338916A1 (en) 2019-04-18
CA3039525A1 (en) 2018-04-12
EP3523328A1 (en) 2019-08-14
US20220306724A1 (en) 2022-09-29
WO2018067874A1 (en) 2018-04-12
KR20230152811A (ko) 2023-11-03
JP7617962B2 (ja) 2025-01-20
AU2022201698A1 (en) 2022-04-07
US20200055919A1 (en) 2020-02-20
EP3523328A4 (en) 2020-04-01

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