AU2017338916B2 - Variant ActRIIB proteins and uses thereof - Google Patents

Variant ActRIIB proteins and uses thereof Download PDF

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Publication number
AU2017338916B2
AU2017338916B2 AU2017338916A AU2017338916A AU2017338916B2 AU 2017338916 B2 AU2017338916 B2 AU 2017338916B2 AU 2017338916 A AU2017338916 A AU 2017338916A AU 2017338916 A AU2017338916 A AU 2017338916A AU 2017338916 B2 AU2017338916 B2 AU 2017338916B2
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amino acid
seq
polypeptide
actriib
acid sequence
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AU2017338916A
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AU2017338916A1 (en
Inventor
Asya Grinberg
Ravindra Kumar
Erik M. Vogan
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2017338916A 2016-10-05 2017-10-05 Variant ActRIIB proteins and uses thereof Active AU2017338916B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022201698A AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof
AU2024200684A AU2024200684A1 (en) 2016-10-05 2024-02-05 Variant ActRIIB proteins and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404718P 2016-10-05 2016-10-05
US62/404,718 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

Related Child Applications (1)

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AU2022201698A Division AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof

Publications (2)

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AU2017338916A1 AU2017338916A1 (en) 2019-04-18
AU2017338916B2 true AU2017338916B2 (en) 2022-03-24

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AU2017338916A Active AU2017338916B2 (en) 2016-10-05 2017-10-05 Variant ActRIIB proteins and uses thereof
AU2022201698A Abandoned AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof
AU2024200684A Abandoned AU2024200684A1 (en) 2016-10-05 2024-02-05 Variant ActRIIB proteins and uses thereof

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AU2024200684A Abandoned AU2024200684A1 (en) 2016-10-05 2024-02-05 Variant ActRIIB proteins and uses thereof

Country Status (10)

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US (2) US11267865B2 (enExample)
EP (1) EP3523328A4 (enExample)
JP (2) JP7280182B2 (enExample)
KR (2) KR102595559B1 (enExample)
CN (1) CN110036025B (enExample)
AU (3) AU2017338916B2 (enExample)
BR (1) BR112019006918A2 (enExample)
CA (1) CA3039525A1 (enExample)
MA (1) MA46471A (enExample)
WO (1) WO2018067874A1 (enExample)

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EP3706777B1 (en) 2017-11-09 2024-05-22 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
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AU2019262139A1 (en) * 2018-05-03 2020-11-26 Acceleron Pharma Inc. Multispecific binders of TGFβ-superfamily ligands and uses thereof
IL278546B2 (en) * 2018-05-09 2026-03-01 Keros Therapeutics Inc Activin receptor type IIA variants and methods of using them
US20220089683A1 (en) * 2018-06-15 2022-03-24 Acceleron Pharma Inc. Bi-and tri-functional fusion proteins and uses thereof
CN109293763B (zh) * 2018-10-26 2021-10-26 中国农业科学院特产研究所 水貂激活素b蛋白及其制备与应用
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US20230183319A1 (en) * 2020-02-03 2023-06-15 Acceleron Pharma Inc. Variant actriib proteins and uses thereof
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EP4121078A4 (en) 2020-03-20 2024-08-14 Keros Therapeutics, Inc. ACTIVIN RECEPTOR TYPE II CHIMERAS AND METHODS OF USE THEREOF
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AU2021273014A1 (en) 2020-05-13 2022-11-17 AbbVie Deutschland GmbH & Co. KG Anti-hemojuvelin (HJV) antibodies for treating anemia of chronic disease
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US20240181007A1 (en) * 2021-01-08 2024-06-06 Acceleron Pharma Inc. Compositions and methods for treating pulmonary hypertension
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MA46471A (fr) 2021-05-19
KR102595559B1 (ko) 2023-10-30
US12240887B2 (en) 2025-03-04
AU2024200684A1 (en) 2024-02-22
KR20190073414A (ko) 2019-06-26
JP2023033573A (ja) 2023-03-10
CN110036025A (zh) 2019-07-19
KR102761094B1 (ko) 2025-02-03
JP2019536440A (ja) 2019-12-19
BR112019006918A2 (pt) 2019-06-25
US11267865B2 (en) 2022-03-08
CN110036025B (zh) 2024-03-22
AU2017338916A1 (en) 2019-04-18
CA3039525A1 (en) 2018-04-12
EP3523328A1 (en) 2019-08-14
US20220306724A1 (en) 2022-09-29
WO2018067874A1 (en) 2018-04-12
KR20230152811A (ko) 2023-11-03
JP7617962B2 (ja) 2025-01-20
AU2022201698A1 (en) 2022-04-07
US20200055919A1 (en) 2020-02-20
JP7280182B2 (ja) 2023-05-23
EP3523328A4 (en) 2020-04-01

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