AU2017338916B2 - Variant ActRIIB proteins and uses thereof - Google Patents

Variant ActRIIB proteins and uses thereof Download PDF

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Publication number
AU2017338916B2
AU2017338916B2 AU2017338916A AU2017338916A AU2017338916B2 AU 2017338916 B2 AU2017338916 B2 AU 2017338916B2 AU 2017338916 A AU2017338916 A AU 2017338916A AU 2017338916 A AU2017338916 A AU 2017338916A AU 2017338916 B2 AU2017338916 B2 AU 2017338916B2
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Australia
Prior art keywords
amino acid
seq
polypeptide
actriib
acid sequence
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AU2017338916A
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AU2017338916A1 (en
Inventor
Asya Grinberg
Ravindra Kumar
Erik M. Vogan
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Publication of AU2017338916A1 publication Critical patent/AU2017338916A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2017338916A 2016-10-05 2017-10-05 Variant ActRIIB proteins and uses thereof Active AU2017338916B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022201698A AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof
AU2024200684A AU2024200684A1 (en) 2016-10-05 2024-02-05 Variant ActRIIB proteins and uses thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404718P 2016-10-05 2016-10-05
US62/404,718 2016-10-05
PCT/US2017/055421 WO2018067874A1 (en) 2016-10-05 2017-10-05 Variant actriib proteins and uses thereof

Related Child Applications (1)

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AU2022201698A Division AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof

Publications (2)

Publication Number Publication Date
AU2017338916A1 AU2017338916A1 (en) 2019-04-18
AU2017338916B2 true AU2017338916B2 (en) 2022-03-24

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Family Applications (3)

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AU2017338916A Active AU2017338916B2 (en) 2016-10-05 2017-10-05 Variant ActRIIB proteins and uses thereof
AU2022201698A Abandoned AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof
AU2024200684A Pending AU2024200684A1 (en) 2016-10-05 2024-02-05 Variant ActRIIB proteins and uses thereof

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AU2022201698A Abandoned AU2022201698A1 (en) 2016-10-05 2022-03-11 Variant ActRIIB proteins and uses thereof
AU2024200684A Pending AU2024200684A1 (en) 2016-10-05 2024-02-05 Variant ActRIIB proteins and uses thereof

Country Status (10)

Country Link
US (2) US11267865B2 (enExample)
EP (1) EP3523328A4 (enExample)
JP (2) JP7280182B2 (enExample)
KR (2) KR102595559B1 (enExample)
CN (1) CN110036025B (enExample)
AU (3) AU2017338916B2 (enExample)
BR (1) BR112019006918A2 (enExample)
CA (1) CA3039525A1 (enExample)
MA (1) MA46471A (enExample)
WO (1) WO2018067874A1 (enExample)

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SMT202300166T1 (it) 2014-12-03 2023-07-20 Celgene Corp Antagonisti di attivina- actrii e usi per il trattamento di sindrome mielodisplastica
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WO2018067874A1 (en) 2016-10-05 2018-04-12 Acceleron Pharma Inc. Variant actriib proteins and uses thereof
JOP20190085A1 (ar) * 2016-10-20 2019-04-17 Biogen Ma Inc طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة
EP3538123A4 (en) 2016-11-10 2020-10-14 Keros Therapeutics, Inc. ACTIVIN RECEPTOR TYPE IIA VARIANTS AND THEIR METHODS OF USE
CA3082146A1 (en) 2017-11-09 2019-05-16 Keros Therapeutics, Inc. Activin receptor type iia variants and methods of use thereof
CN120399032A (zh) 2018-01-12 2025-08-01 科乐斯疗法公司 激活素受体iib型变体及其使用方法
JP2021522793A (ja) 2018-05-03 2021-09-02 アクセルロン ファーマ インコーポレイテッド ＴＧＦβスーパーファミリーリガンドの多特異性バインダーおよびその使用
EP3788067A4 (en) * 2018-05-03 2022-01-19 Acceleron Pharma Inc. NOVEL BINDERS OF TGFBETA SUPERFAMILY LIGANDS AND THEIR USES
EP3790572A4 (en) 2018-05-09 2022-03-16 Keros Therapeutics, Inc. ACTIVIN RECEPTOR TYPE IIA VARIANTS AND METHODS OF USE THEREOF
EP3807308A4 (en) * 2018-06-15 2022-03-16 Acceleron Pharma Inc. BI AND TRIFUNCTIONAL FUSION PROTEINS AND THEIR USES
CN109293763B (zh) * 2018-10-26 2021-10-26 中国农业科学院特产研究所 水貂激活素b蛋白及其制备与应用
KR20220088699A (ko) 2019-09-27 2022-06-28 디스크 메디슨, 인크. 골수섬유증 및 관련 상태의 치료 방법
BR112022015387A2 (pt) * 2020-02-03 2022-10-11 Acceleron Pharma Inc Proteínas actriib variantes e usos das mesmas
EP4121088A4 (en) * 2020-03-20 2024-07-03 Keros Therapeutics, Inc. Methods of using activin receptor type iib variants
WO2021189006A1 (en) * 2020-03-20 2021-09-23 Keros Therapeutics, Inc. Methods of using activin receptor type iia variants
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
EP4171603A4 (en) * 2020-06-25 2024-06-26 Gliknik Inc. ACE2-FC FUSION PROTEINS AND METHODS OF USE
US12186370B1 (en) 2020-11-05 2025-01-07 Celgene Corporation ACTRIIB ligand trap compositions and uses thereof
EP4274600A4 (en) * 2021-01-08 2024-11-20 Acceleron Pharma Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF PULMONARY HYPERTENSION
IL314280A (en) 2022-01-28 2024-09-01 35Pharma Inc Type IIB activin receptor variants and their uses

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Also Published As

Publication number Publication date
CA3039525A1 (en) 2018-04-12
CN110036025A (zh) 2019-07-19
EP3523328A4 (en) 2020-04-01
KR102761094B1 (ko) 2025-02-03
US11267865B2 (en) 2022-03-08
MA46471A (fr) 2021-05-19
BR112019006918A2 (pt) 2019-06-25
KR102595559B1 (ko) 2023-10-30
JP7617962B2 (ja) 2025-01-20
CN110036025B (zh) 2024-03-22
US12240887B2 (en) 2025-03-04
JP2023033573A (ja) 2023-03-10
AU2024200684A1 (en) 2024-02-22
WO2018067874A1 (en) 2018-04-12
AU2017338916A1 (en) 2019-04-18
US20200055919A1 (en) 2020-02-20
JP2019536440A (ja) 2019-12-19
JP7280182B2 (ja) 2023-05-23
KR20230152811A (ko) 2023-11-03
EP3523328A1 (en) 2019-08-14
KR20190073414A (ko) 2019-06-26
US20220306724A1 (en) 2022-09-29
AU2022201698A1 (en) 2022-04-07

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