CA3027124A1 - Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response - Google Patents

Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response Download PDF

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Publication number
CA3027124A1
CA3027124A1 CA3027124A CA3027124A CA3027124A1 CA 3027124 A1 CA3027124 A1 CA 3027124A1 CA 3027124 A CA3027124 A CA 3027124A CA 3027124 A CA3027124 A CA 3027124A CA 3027124 A1 CA3027124 A1 CA 3027124A1
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Prior art keywords
amino acid
cell
acid sequence
seq
sequence
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CA3027124A
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English (en)
French (fr)
Inventor
Jurgen Herbert Ernst Kuball
Anke JANSSEN
Dennis BERINGER
Paul Fisch
Jose Alberto VILLACORTA HIDALGO
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Albert Ludwigs Universitaet Freiburg
Gadeta Bv
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Albert Ludwigs Universitaet Freiburg
Gadeta Bv
UMC Utrecht Holding BV
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Publication of CA3027124A1 publication Critical patent/CA3027124A1/en
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
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    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CA3027124A 2016-06-10 2017-06-12 Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response Pending CA3027124A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16173986 2016-06-10
EP16173986.7 2016-06-10
EP16173970 2016-06-10
PCT/EP2017/064325 WO2017212074A1 (en) 2016-06-10 2017-06-12 Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response
EP16173970.1 2019-06-10

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Publication Number Publication Date
CA3027124A1 true CA3027124A1 (en) 2017-12-14

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CA3027124A Pending CA3027124A1 (en) 2016-06-10 2017-06-12 Novel method for identifying deltat-cell (or gammat-cell) receptor chains or parts thereof that mediate an anti-tumour or an anti-infective response
CA3026180A Pending CA3026180A1 (en) 2016-06-10 2017-06-12 Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof

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Application Number Title Priority Date Filing Date
CA3026180A Pending CA3026180A1 (en) 2016-06-10 2017-06-12 Human leukocyte antigen restricted gamma delta t cell receptors and methods of use thereof

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US (5) US11166984B2 (cg-RX-API-DMAC7.html)
EP (4) EP3469362B1 (cg-RX-API-DMAC7.html)
JP (1) JP2019525898A (cg-RX-API-DMAC7.html)
KR (1) KR102489954B1 (cg-RX-API-DMAC7.html)
CN (1) CN109997041B (cg-RX-API-DMAC7.html)
CA (2) CA3027124A1 (cg-RX-API-DMAC7.html)
ES (1) ES2987986T3 (cg-RX-API-DMAC7.html)
HU (1) HUE068936T2 (cg-RX-API-DMAC7.html)
PL (1) PL3469361T3 (cg-RX-API-DMAC7.html)
WO (2) WO2017212074A1 (cg-RX-API-DMAC7.html)

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EP3624823A1 (en) 2017-05-18 2020-03-25 UMC Utrecht Holding B.V. Compositions and methods for cell targeting therapies
WO2019156566A1 (en) * 2018-02-12 2019-08-15 Umc Utrecht Holding B.V. Bispecific molecules comprising gamma-delta tcr and t-cell or nk cell binding domain
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WO2019219979A1 (en) 2018-05-18 2019-11-21 Umc Utrecht Holding B.V. Compositions and methods for cell targeting therapies
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WO2021220132A1 (en) 2020-04-27 2021-11-04 Novartis Ag Methods and compositions for ocular cell therapy
EP4267604A1 (en) 2020-12-23 2023-11-01 Gadeta B.V. Chimeric, transmembrane proteins with bidirectional signalling activity
CN113046320B (zh) * 2021-02-19 2023-04-14 中国医学科学院基础医学研究所 胞外段为Vδ1(GTM)Vγ4的CAR分子及表达该分子的CAR-T细胞及其用途
EP4059955A1 (en) 2021-03-19 2022-09-21 Medizinische Hochschule Hannover Hla-dr-specific gamma delta tcr constructs and use thereof
WO2022214707A1 (en) 2021-04-09 2022-10-13 Gadeta B.V. Cellular reporter and methods of using the same
WO2022258606A1 (en) 2021-06-07 2022-12-15 Gadeta B.V. Delta T-cell or Gamma T-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
JP2024525727A (ja) 2021-07-14 2024-07-12 2セブンティ バイオ インコーポレイテッド 抗体由来の結合ドメインに融合した操作されたt細胞受容体
KR20250008809A (ko) 2022-04-08 2025-01-15 리제너론 파마슈티칼스 인코포레이티드 다분할 수용체 및 신호전달 복합체
WO2023227594A1 (en) 2022-05-24 2023-11-30 Gadeta Bv Novel deltat-cell receptor chains, gammat-cell receptor chains, or parts thereof
WO2023237541A1 (en) 2022-06-07 2023-12-14 Gadeta B.V. Delta t-cell or gamma t-cell receptor chains or parts thereof that mediate an anti-tumour or anti-infective response
WO2023242434A1 (en) 2022-06-17 2023-12-21 Gadeta B.V. Modified immune cells
US20240075068A1 (en) * 2022-07-15 2024-03-07 Gadeta B.V. Novel soluble gamma T-cell (or soluble delta T-cell) receptor chains (or soluble gammadelta T-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
US20240043496A1 (en) * 2022-07-26 2024-02-08 Gadeta B.V. Delta t-cell or gamma receptor chains or parts thereof for treating ovarian cancer
WO2025231488A1 (en) * 2024-05-03 2025-11-06 Northwestern University Gamma-delta t cell receptors for cancer therapy

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