CA3026327A1 - Methods and compositions for preventing infection by a vibrio species - Google Patents
Methods and compositions for preventing infection by a vibrio species Download PDFInfo
- Publication number
- CA3026327A1 CA3026327A1 CA3026327A CA3026327A CA3026327A1 CA 3026327 A1 CA3026327 A1 CA 3026327A1 CA 3026327 A CA3026327 A CA 3026327A CA 3026327 A CA3026327 A CA 3026327A CA 3026327 A1 CA3026327 A1 CA 3026327A1
- Authority
- CA
- Canada
- Prior art keywords
- phage
- strains
- icp
- cholerae
- infection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 108
- 238000000034 method Methods 0.000 title claims abstract description 70
- 241000607598 Vibrio Species 0.000 title claims abstract description 55
- 208000015181 infectious disease Diseases 0.000 title claims description 113
- 241000607626 Vibrio cholerae Species 0.000 claims abstract description 174
- 230000002101 lytic effect Effects 0.000 claims abstract description 76
- 241001515965 unidentified phage Species 0.000 claims abstract description 76
- 230000001580 bacterial effect Effects 0.000 claims abstract description 74
- 206010008631 Cholera Diseases 0.000 claims abstract description 66
- 241000894007 species Species 0.000 claims abstract description 24
- 230000003115 biocidal effect Effects 0.000 claims abstract description 16
- 241001465754 Metazoa Species 0.000 claims description 103
- 101001044255 Entamoeba histolytica Amoebiasin-2 Proteins 0.000 claims description 51
- 101001042083 Entamoeba histolytica Amoebiasin-1 Proteins 0.000 claims description 50
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 40
- 238000010171 animal model Methods 0.000 claims description 20
- 208000035143 Bacterial infection Diseases 0.000 claims description 16
- 239000002158 endotoxin Substances 0.000 claims description 16
- 229920006008 lipopolysaccharide Polymers 0.000 claims description 16
- 239000003242 anti bacterial agent Substances 0.000 claims description 15
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- 210000002845 virion Anatomy 0.000 claims description 15
- 208000024891 symptom Diseases 0.000 claims description 13
- 244000005700 microbiome Species 0.000 claims description 11
- 230000000069 prophylactic effect Effects 0.000 claims description 11
- 206010047400 Vibrio infections Diseases 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 229940118696 vibrio cholerae Drugs 0.000 claims description 10
- 229940124597 therapeutic agent Drugs 0.000 claims description 7
- 230000007613 environmental effect Effects 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 241001453243 Campylobacter sputorum subsp. bubulus Species 0.000 claims description 4
- 241000332146 Vibrio aerogenes Species 0.000 claims description 4
- 241001676766 Vibrio aestivus Species 0.000 claims description 4
- 241001135143 Vibrio aestuarianus Species 0.000 claims description 4
- 241001231453 Vibrio albensis Species 0.000 claims description 4
- 241000607594 Vibrio alginolyticus Species 0.000 claims description 4
- 241000544286 Vibrio anguillarum Species 0.000 claims description 4
- 241001500064 Vibrio areninigrae Species 0.000 claims description 4
- 241000452627 Vibrio artabrorum Species 0.000 claims description 4
- 241000607323 Vibrio campbellii Species 0.000 claims description 4
- 241000944835 Vibrio casei Species 0.000 claims description 4
- 241000607296 Vibrio cincinnatiensis Species 0.000 claims description 4
- 241001025870 Vibrio crassostreae Species 0.000 claims description 4
- 241000607306 Vibrio diazotrophicus Species 0.000 claims description 4
- 241001349548 Vibrio ezurae Species 0.000 claims description 4
- 241001180047 Vibrio gigantis Species 0.000 claims description 4
- 241000965623 Vibrio lentus Species 0.000 claims description 4
- 241001135144 Vibrio metschnikovii Species 0.000 claims description 4
- 241000501793 Vibrio mytili Species 0.000 claims description 4
- 241000607365 Vibrio natriegens Species 0.000 claims description 4
- 241000681718 Vibrio neptunius Species 0.000 claims description 4
- 241000607359 Vibrio nereis Species 0.000 claims description 4
- 241000690895 Vibrio pacinii Species 0.000 claims description 4
- 241000896074 Vibrio pectenicida Species 0.000 claims description 4
- 241001517161 Vibrio pomeroyi Species 0.000 claims description 4
- 241001290502 Vibrio rumoiensis Species 0.000 claims description 4
- 241000193098 Vibrio scophthalmi Species 0.000 claims description 4
- 241001148079 Vibrio splendidus Species 0.000 claims description 4
- 241000510690 Vibrio tapetis Species 0.000 claims description 4
- 241001552442 Vibrio tasmaniensis Species 0.000 claims description 4
- 241000607265 Vibrio vulnificus Species 0.000 claims description 4
- 230000000670 limiting effect Effects 0.000 claims description 4
- 241000607337 Aliivibrio logei Species 0.000 claims description 3
- 241000305093 Enterovibrio calviensis Species 0.000 claims description 3
- 241000283073 Equus caballus Species 0.000 claims description 3
- 241001656470 Vibrio agarivorans Species 0.000 claims description 3
- 241000762753 Vibrio alfacsensis Species 0.000 claims description 3
- 241000549284 Vibrio atypicus Species 0.000 claims description 3
- 241000674191 Vibrio azureus Species 0.000 claims description 3
- 241001407018 Vibrio coralliilyticus Species 0.000 claims description 3
- 241000501799 Vibrio diabolicus Species 0.000 claims description 3
- 241000607291 Vibrio fluvialis Species 0.000 claims description 3
- 241001552433 Vibrio fortis Species 0.000 claims description 3
- 241001148070 Vibrio furnissii Species 0.000 claims description 3
- 241001407022 Vibrio gallicus Species 0.000 claims description 3
- 241000607339 Vibrio gazogenes Species 0.000 claims description 3
- 241001234514 Vibrio halioticoli Species 0.000 claims description 3
- 241000607618 Vibrio harveyi Species 0.000 claims description 3
- 241000210080 Vibrio hippocampi Species 0.000 claims description 3
- 241001268204 Vibrio ichthyoenteri Species 0.000 claims description 3
- 241000944752 Vibrio indicus Species 0.000 claims description 3
- 241000690894 Vibrio kanaloae Species 0.000 claims description 3
- 241000607334 Vibrio mediterranei Species 0.000 claims description 3
- 241001148073 Vibrio navarrensis Species 0.000 claims description 3
- 241001135145 Vibrio nigripulchritudo Species 0.000 claims description 3
- 241001135139 Vibrio ordalii Species 0.000 claims description 3
- 241001135140 Vibrio orientalis Species 0.000 claims description 3
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims description 3
- 241001490532 Vibrio penaeicida Species 0.000 claims description 3
- 241000607269 Vibrio proteolyticus Species 0.000 claims description 3
- 241001407024 Vibrio rotiferianus Species 0.000 claims description 3
- 241001086881 Vibrio ruber Species 0.000 claims description 3
- 241001517090 Vibrio superstes Species 0.000 claims description 3
- 241001148039 Vibrio tubiashii Species 0.000 claims description 3
- 241000681724 Vibrio xuii Species 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000002269 spontaneous effect Effects 0.000 claims description 3
- 241000251468 Actinopterygii Species 0.000 claims description 2
- 241000122170 Aliivibrio salmonicida Species 0.000 claims description 2
- 241000726096 Aratinga Species 0.000 claims description 2
- 101710116435 Outer membrane protein Proteins 0.000 claims description 2
- 241001520299 Phascolarctos cinereus Species 0.000 claims description 2
- 241000287531 Psittacidae Species 0.000 claims description 2
- 241000283984 Rodentia Species 0.000 claims description 2
- 241000607253 Vibrio mimicus Species 0.000 claims description 2
- 230000000843 anti-fungal effect Effects 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 230000000884 anti-protozoa Effects 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 235000013373 food additive Nutrition 0.000 claims description 2
- 239000002778 food additive Substances 0.000 claims description 2
- 230000000887 hydrating effect Effects 0.000 claims description 2
- 238000009155 rehydration therapy Methods 0.000 claims description 2
- 241001672646 Vibrio atlanticus Species 0.000 claims 2
- 241000690888 Vibrio chagasii Species 0.000 claims 2
- 241000694781 Vibrio hepatarius Species 0.000 claims 2
- 241000276415 Vibrio hispanicus Species 0.000 claims 2
- 241000681719 Vibrio brasiliensis Species 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 48
- 230000035772 mutation Effects 0.000 abstract description 30
- 201000010099 disease Diseases 0.000 abstract description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 23
- 238000011282 treatment Methods 0.000 abstract description 22
- 230000000813 microbial effect Effects 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 61
- 241000699670 Mus sp. Species 0.000 description 55
- 210000000813 small intestine Anatomy 0.000 description 37
- 238000011321 prophylaxis Methods 0.000 description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 31
- 230000002829 reductive effect Effects 0.000 description 22
- 238000003556 assay Methods 0.000 description 21
- 239000012530 fluid Substances 0.000 description 21
- 238000004458 analytical method Methods 0.000 description 18
- 239000013543 active substance Substances 0.000 description 17
- 239000000427 antigen Substances 0.000 description 17
- 230000000968 intestinal effect Effects 0.000 description 17
- 108020003175 receptors Proteins 0.000 description 17
- 230000005540 biological transmission Effects 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- 230000012010 growth Effects 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 15
- 206010012735 Diarrhoea Diseases 0.000 description 13
- 239000008194 pharmaceutical composition Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 230000037396 body weight Effects 0.000 description 12
- 210000000936 intestine Anatomy 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 241000282412 Homo Species 0.000 description 11
- 210000001035 gastrointestinal tract Anatomy 0.000 description 11
- 241000699666 Mus <mouse, genus> Species 0.000 description 10
- 229940088710 antibiotic agent Drugs 0.000 description 10
- 244000052616 bacterial pathogen Species 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- 238000011161 development Methods 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 230000002147 killing effect Effects 0.000 description 9
- 101100214867 Autographa californica nuclear polyhedrosis virus AC53 gene Proteins 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 230000001717 pathogenic effect Effects 0.000 description 8
- 229920001223 polyethylene glycol Polymers 0.000 description 8
- 230000035945 sensitivity Effects 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 229920002101 Chitin Polymers 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 7
- 241000736262 Microbiota Species 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 230000001018 virulence Effects 0.000 description 7
- 108700023313 Bacteriophage Receptors Proteins 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- -1 calreticul in Chemical class 0.000 description 6
- 210000004534 cecum Anatomy 0.000 description 6
- 239000003937 drug carrier Substances 0.000 description 6
- 230000002458 infectious effect Effects 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 238000010172 mouse model Methods 0.000 description 6
- 238000007747 plating Methods 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 239000006137 Luria-Bertani broth Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000014509 gene expression Effects 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 238000002955 isolation Methods 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 238000011555 rabbit model Methods 0.000 description 5
- 201000009881 secretory diarrhea Diseases 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 206010022678 Intestinal infections Diseases 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 244000005709 gut microbiome Species 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 239000003701 inert diluent Substances 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 230000001320 lysogenic effect Effects 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 238000001066 phage therapy Methods 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 230000010076 replication Effects 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 239000007909 solid dosage form Substances 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 230000004580 weight loss Effects 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 238000010453 CRISPR/Cas method Methods 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000013505 freshwater Substances 0.000 description 3
- 238000012268 genome sequencing Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000003362 replicative effect Effects 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 229960005322 streptomycin Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- 239000000304 virulence factor Substances 0.000 description 3
- 230000007923 virulence factor Effects 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 2
- 241001600138 Aliivibrio wodanis Species 0.000 description 2
- 241000416162 Astragalus gummifer Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 description 2
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 238000012313 Kruskal-Wallis test Methods 0.000 description 2
- 239000006142 Luria-Bertani Agar Substances 0.000 description 2
- 102400000058 Neuregulin-1 Human genes 0.000 description 2
- 108090000556 Neuregulin-1 Proteins 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 102000013275 Somatomedins Human genes 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 102000009618 Transforming Growth Factors Human genes 0.000 description 2
- 108010009583 Transforming Growth Factors Proteins 0.000 description 2
- 240000004381 Verbena brasiliensis Species 0.000 description 2
- 241000602423 Vibrio cholerae O1 Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 235000012216 bentonite Nutrition 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 229920002988 biodegradable polymer Polymers 0.000 description 2
- 239000004621 biodegradable polymer Substances 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 230000001332 colony forming effect Effects 0.000 description 2
- 235000012343 cottonseed oil Nutrition 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000007123 defense Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000002224 dissection Methods 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 229940126864 fibroblast growth factor Drugs 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000008297 liquid dosage form Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000011201 multiple comparisons test Methods 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000000346 nonvolatile oil Substances 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 101150055431 ompU gene Proteins 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000003305 oral gavage Methods 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 101150021331 toxR gene Proteins 0.000 description 2
- 239000000196 tragacanth Substances 0.000 description 2
- 235000010487 tragacanth Nutrition 0.000 description 2
- 229940116362 tragacanth Drugs 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 238000012070 whole genome sequencing analysis Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- CUKWUWBLQQDQAC-VEQWQPCFSA-N (3s)-3-amino-4-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s,3s)-1-[[(2s)-1-[(2s)-2-[[(1s)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-ox Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 CUKWUWBLQQDQAC-VEQWQPCFSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 101100284517 Aneurinibacillus thermoaerophilus hddC gene Proteins 0.000 description 1
- QMMRCKSBBNJCMR-KMZPNFOHSA-N Angiotensin III Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCN=C(N)N)C(C)C)C1=CC=C(O)C=C1 QMMRCKSBBNJCMR-KMZPNFOHSA-N 0.000 description 1
- 102400000345 Angiotensin-2 Human genes 0.000 description 1
- 101800000733 Angiotensin-2 Proteins 0.000 description 1
- 102400000348 Angiotensin-3 Human genes 0.000 description 1
- 101800000738 Angiotensin-3 Proteins 0.000 description 1
- 235000003276 Apios tuberosa Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000010744 Arachis villosulicarpa Nutrition 0.000 description 1
- 241001243567 Atlanticus Species 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 108700003860 Bacterial Genes Proteins 0.000 description 1
- 208000034309 Bacterial disease carrier Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000282805 Ceratotherium simum Species 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000777300 Congiopodidae Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 208000027244 Dysbiosis Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 208000032163 Emerging Communicable disease Diseases 0.000 description 1
- 241000194033 Enterococcus Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 101710105759 Major outer membrane porin Proteins 0.000 description 1
- 101710164702 Major outer membrane protein Proteins 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010048723 Multiple-drug resistance Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000701553 Myoviridae Species 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 241000702072 Podoviridae Species 0.000 description 1
- 229920002732 Polyanhydride Polymers 0.000 description 1
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 206010039438 Salmonella Infections Diseases 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- SSZBUIDZHHWXNJ-UHFFFAOYSA-N Stearinsaeure-hexadecylester Natural products CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCC SSZBUIDZHHWXNJ-UHFFFAOYSA-N 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 102000002938 Thrombospondin Human genes 0.000 description 1
- 108060008245 Thrombospondin Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 241000219284 Vibrio cyclitrophicus Species 0.000 description 1
- 241000369309 Vibrio litoralis Species 0.000 description 1
- 241000092104 Vibrio ponticus Species 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229950006323 angiotensin ii Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 210000003578 bacterial chromosome Anatomy 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960002903 benzyl benzoate Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960005004 cholera vaccine Drugs 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000002442 collagenase inhibitor Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000000741 diarrhetic effect Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 230000007140 dysbiosis Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229940093499 ethyl acetate Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 230000005567 fecaloral disease transmission Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 230000005182 global health Effects 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 101150039741 hldD gene Proteins 0.000 description 1
- 244000005702 human microbiome Species 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 230000028744 lysogeny Effects 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000012768 mass vaccination Methods 0.000 description 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 description 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000007479 molecular analysis Methods 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 208000037971 neglected tropical disease Diseases 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 230000001937 non-anti-biotic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- UEHGPSGGFKLPTD-KVTDHHQDSA-N perosamine Chemical compound C[C@@H](O)[C@@H](N)[C@H](O)[C@H](O)C=O UEHGPSGGFKLPTD-KVTDHHQDSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- MFZOSKPPVCIFMT-UHFFFAOYSA-N pinazepam Chemical compound C12=CC(Cl)=CC=C2N(CC#C)C(=O)CN=C1C1=CC=CC=C1 MFZOSKPPVCIFMT-UHFFFAOYSA-N 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000000899 pressurised-fluid extraction Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 1
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000008261 resistance mechanism Effects 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 206010039447 salmonellosis Diseases 0.000 description 1
- 238000013341 scale-up Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013376 serial cultivation Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 101150101459 tx gene Proteins 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00032—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662316704P | 2016-04-01 | 2016-04-01 | |
| US62/316,704 | 2016-04-01 | ||
| PCT/US2017/025305 WO2017173229A1 (en) | 2016-04-01 | 2017-03-31 | Methods and compositions for preventing infection by a vibrio species |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3026327A1 true CA3026327A1 (en) | 2017-10-05 |
Family
ID=59966476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3026327A Abandoned CA3026327A1 (en) | 2016-04-01 | 2017-03-31 | Methods and compositions for preventing infection by a vibrio species |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10953053B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3436611A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2019510052A (cg-RX-API-DMAC7.html) |
| KR (4) | KR102755264B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109310722A (cg-RX-API-DMAC7.html) |
| CA (1) | CA3026327A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017173229A1 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109517804A (zh) * | 2018-11-19 | 2019-03-26 | 扬州大学 | 一种具有跨种裂解特性的拟态弧菌噬菌体oy-1、制备方法及其应用 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0811530B1 (pt) | 2007-05-14 | 2019-01-02 | Research Foundation Of State Univ Of New York | composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície |
| CN107904214A (zh) * | 2017-10-13 | 2018-04-13 | 深圳先进技术研究院 | 溶藻弧菌噬菌体及包含该噬菌体的杀菌组合物 |
| CN107904211B (zh) * | 2017-10-13 | 2024-03-19 | 深圳先进技术研究院 | 副溶血弧菌噬菌体及包含该噬菌体的杀菌组合物 |
| CN107904213A (zh) * | 2017-10-13 | 2018-04-13 | 深圳先进技术研究院 | 溶藻弧菌噬菌体及包含该噬菌体的杀菌组合物 |
| CN107904212A (zh) * | 2017-10-13 | 2018-04-13 | 深圳先进技术研究院 | 溶藻弧菌噬菌体及包含该噬菌体的杀菌组合物 |
| CN107805630B (zh) * | 2017-10-13 | 2024-03-19 | 深圳先进技术研究院 | 副溶血弧菌噬菌体及包含该噬菌体的杀菌组合物 |
| CN107805629B (zh) * | 2017-10-13 | 2023-03-21 | 深圳先进技术研究院 | 溶藻弧菌噬菌体及包含该噬菌体的杀菌组合物 |
| CN108048409A (zh) * | 2017-11-20 | 2018-05-18 | 深圳先进技术研究院 | 裂性弧菌噬菌体ValLY-3及包含该噬菌体的杀菌组合物及其应用 |
| CN108048412A (zh) * | 2017-11-20 | 2018-05-18 | 深圳先进技术研究院 | 裂性弧菌噬菌体ValLY-4及包含该噬菌体的杀菌组合物及其应用 |
| CN107988171A (zh) * | 2017-11-20 | 2018-05-04 | 深圳先进技术研究院 | 裂性弧菌噬菌体ValSw4-1及包含该噬菌体的杀菌组合物及其应用 |
| CN108070570A (zh) * | 2017-11-20 | 2018-05-25 | 深圳先进技术研究院 | 裂性弧菌噬菌体ValDsh-1及包含该噬菌体的杀菌组合物及其应用 |
| CN108048411A (zh) * | 2017-11-20 | 2018-05-18 | 深圳先进技术研究院 | 裂性弧菌噬菌体ValLY-2及包含该噬菌体的杀菌组合物及其应用 |
| CN108048410B (zh) * | 2017-11-20 | 2023-06-27 | 深圳先进技术研究院 | 裂性弧菌噬菌体VspSw-1及包含该噬菌体的杀菌组合物及其应用 |
| CN107988172A (zh) * | 2017-11-20 | 2018-05-04 | 深圳先进技术研究院 | 裂性弧菌噬菌体VpaJT-1及包含该噬菌体的杀菌组合物及其应用 |
| EP3798304B1 (en) * | 2018-05-22 | 2024-12-11 | Jichi Medical University | Antibacterial phage, treatment composition, disinfectant, food, kit for identifying bacteria, method for producing treatment composition, method for eliminating bacteria, method for identifying bacteria, and method for treating animals |
| CN110352880B (zh) * | 2019-08-13 | 2021-04-20 | 宁波大学 | 一种紫菜黄斑病的治疗方法 |
| CN112391358B (zh) * | 2019-08-14 | 2023-12-01 | 宁波大学 | 地中海弧菌烈性噬菌体vB_VmeM-Yong及其应用 |
| CN111826309A (zh) * | 2020-06-30 | 2020-10-27 | 武汉合缘绿色生物股份有限公司 | 一种液体生物营养菌剂及其制备方法 |
| CN112029733B (zh) * | 2020-09-24 | 2021-11-26 | 瑞科盟(青岛)生物工程有限公司 | 一株高裂解性溶藻弧菌噬菌体rdp-vp-19001及其应用 |
| CN112011520B (zh) * | 2020-10-30 | 2021-01-19 | 中国科学院南海海洋研究所 | 一种调控珊瑚菌群的温和噬菌体VneM1及其应用 |
| CN112553171B (zh) * | 2020-12-27 | 2022-06-21 | 威海长青海洋科技股份有限公司 | 一种弧菌噬菌体制剂及其应用 |
| CN112646786A (zh) * | 2021-01-21 | 2021-04-13 | 海南海壹水产种苗有限公司 | 一株坎式弧菌噬菌体快速初步分离方法 |
| CN113201505B (zh) * | 2021-04-02 | 2023-12-29 | 青岛诺安百特生物技术有限公司 | 一株具备跨种裂解能力的溶藻弧菌噬菌体、其噬菌体组合物及其应用 |
| KR102774411B1 (ko) * | 2021-10-27 | 2025-02-27 | 전북대학교산학협력단 | 재증식 풀 컬쳐 기반 박테리오파지 스크리닝 방법 |
| CN116103183A (zh) * | 2022-03-30 | 2023-05-12 | 山东科技大学 | 一株脱除高盐硬水中钙离子的巨大弧菌及其应用 |
| CN114774371B (zh) * | 2022-06-21 | 2022-09-13 | 中国海洋大学 | 一种弧菌噬菌体及其应用 |
| CN115820569B (zh) * | 2022-08-09 | 2025-01-14 | 青岛诺安百特生物技术有限公司 | 一株奥氏弧菌噬菌体、其噬菌体组合物及其应用 |
| KR20240058217A (ko) | 2022-10-25 | 2024-05-03 | 주식회사 엘지에너지솔루션 | 고분자 고체 전해질 및 이의 제조방법 |
| CN120058874B (zh) * | 2025-04-29 | 2025-09-09 | 中国疾病预防控制中心传染病预防控制所 | 噬菌体蛋白Gp37及其在制备抑制霍乱弧菌定植和毒素分泌的制剂中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU699322B2 (en) | 1994-04-05 | 1998-12-03 | Exponential Biotherapies, Inc. | Antibacterial therapy with genotypically modified bacteriophage |
| JP2003519650A (ja) | 2000-01-11 | 2003-06-24 | イントラリティックス，インコーポレーテッド | 生体複合材料を製造するための生分解性マトリックスとしてのポリマーブレンド |
| US8956628B2 (en) * | 2007-12-13 | 2015-02-17 | Zoetis Products Llc | Bacteriophage preparations and method of use thereof |
| CL2012002902A1 (es) * | 2012-10-17 | 2013-05-03 | Univ Chile | Cepas de bacteriofagos especifica contra bacterias pertenecientes al genero vibrio para la profilaxis y terapia de vibrio anguillarum; y composicion antibacteriana que comprende dicha cepas. |
| WO2014070225A1 (en) * | 2012-10-30 | 2014-05-08 | Deerland Enzymes, Inc. | Prebiotic compositions comprising one or more types of bacteriophage |
| EP3041498B1 (en) * | 2013-09-05 | 2022-02-16 | Massachusetts Institute of Technology | Tuning microbial populations with programmable nucleases |
-
2017
- 2017-03-31 KR KR1020237030274A patent/KR102755264B1/ko active Active
- 2017-03-31 KR KR1020237043358A patent/KR20240005101A/ko not_active Ceased
- 2017-03-31 EP EP17776749.8A patent/EP3436611A4/en not_active Withdrawn
- 2017-03-31 WO PCT/US2017/025305 patent/WO2017173229A1/en not_active Ceased
- 2017-03-31 CA CA3026327A patent/CA3026327A1/en not_active Abandoned
- 2017-03-31 CN CN201780033655.0A patent/CN109310722A/zh active Pending
- 2017-03-31 JP JP2018551147A patent/JP2019510052A/ja active Pending
- 2017-03-31 KR KR1020187031275A patent/KR20190005846A/ko not_active Ceased
- 2017-03-31 KR KR1020227033895A patent/KR20220138015A/ko not_active Ceased
-
2018
- 2018-09-28 US US16/145,836 patent/US10953053B2/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109517804A (zh) * | 2018-11-19 | 2019-03-26 | 扬州大学 | 一种具有跨种裂解特性的拟态弧菌噬菌体oy-1、制备方法及其应用 |
| CN109517804B (zh) * | 2018-11-19 | 2022-06-14 | 扬州大学 | 一种具有跨种裂解特性的拟态弧菌噬菌体oy-1、制备方法及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019510052A (ja) | 2019-04-11 |
| KR20230132886A (ko) | 2023-09-18 |
| US10953053B2 (en) | 2021-03-23 |
| EP3436611A4 (en) | 2019-11-06 |
| KR20220138015A (ko) | 2022-10-12 |
| KR20190005846A (ko) | 2019-01-16 |
| WO2017173229A1 (en) | 2017-10-05 |
| CN109310722A (zh) | 2019-02-05 |
| KR20240005101A (ko) | 2024-01-11 |
| EP3436611A1 (en) | 2019-02-06 |
| KR102755264B1 (ko) | 2025-01-21 |
| US20190099459A1 (en) | 2019-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10953053B2 (en) | Methods and compositions for preventing infection by a Vibrio species | |
| Yuan et al. | Efficacy of a phage cocktail in controlling phage resistance development in multidrug resistant Acinetobacter baumannii | |
| JP2019510052A5 (cg-RX-API-DMAC7.html) | ||
| KR101070938B1 (ko) | 신규한 박테리오파지 및 이를 포함하는 항균 조성물 | |
| Islam et al. | Application of a novel phage ZPAH7 for controlling multidrug-resistant Aeromonas hydrophila on lettuce and reducing biofilms | |
| TWI459951B (zh) | 新穎噬菌體及含該噬菌體之抗菌組成物 | |
| JP5666016B2 (ja) | 新規バクテリオファージ及びそれを含む抗菌組成物 | |
| US8846368B2 (en) | Bacteriophage and antibacterial composition comprising the same | |
| US20190321424A1 (en) | Escherichia coli bacteriophage esc-cop-7, and use thereof for suppressing proliferation of pathogenic escherichia coli | |
| Nicolas et al. | In ovo administration of a phage cocktail partially prevents colibacillosis in chicks | |
| Royam et al. | Isolation, characterization, and efficacy of bacteriophages isolated against Citrobacter spp. an in vivo approach in a zebrafish model (Danio rerio) | |
| US10898531B2 (en) | Vibrio parahaemolyticus bacteriophage Vib-PAP-5 and use thereof for suppressing proliferation of Vibrio parahaemolyticus bacteria | |
| CN113891721A (zh) | 用于调节炎症性肠病的噬菌体 | |
| US11826391B2 (en) | Antibacterial formulation comprising a mixture of bacteriophages; use and method for preventing or treating diseases caused by salmonella spp. in farm animals by oral administration of the formulation | |
| US8771936B2 (en) | Bacteriophage and antibacterial composition comprising the same | |
| Islam et al. | Determination of optimum survivability factors of highly pathogenic Vibrio cholerae 01 serogroup specific bacteriophage JSF4ϕ | |
| Acton | A Functional Genomics Approach for Improved Bacteriophage Cocktail Design | |
| Jumaniyazova et al. | Isolation and characterization of a novel Salmonella polyvalent bacteriophage ‘MediPhag’in Uzbekistan | |
| Fong | Comparative analysis of Salmonella-infecting bacteriophages and characterization of bacteriophage-host interactions | |
| US11351210B2 (en) | Lactococcus garvieae bacteriophage Lac-GAP-3 and use thereof in inhibiting proliferation of Lactococcus garvieae bacteria | |
| Zaib et al. | In-vitro evaluation and efficacy of bacteriophage isolated from commercial poultry farms against Salmonella typhimurium | |
| TAMALE et al. | Bacteriophage Action against Tilapia Fish Aeromonasis in Aquarium Tanks in Uganda | |
| Soltys | Linking Epidemiologically Distinct Genotypes to Phenotypes of Salmonella Kentucky | |
| CN120866235A (zh) | 一株新型烈性副溶血性弧菌噬菌体vB_VpS_CC6及其应用 | |
| 김현중 | Identification of causative agents with high mortality in marine bivalve and application of bacteriophage to prevent Vibrio coralliilyiticus infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20230628 |