CA3019256A1 - Systeme et procede de desorption et de detection d'un analyte adsorbe sur un dispositif de microextraction en phase solide - Google Patents
Systeme et procede de desorption et de detection d'un analyte adsorbe sur un dispositif de microextraction en phase solide Download PDFInfo
- Publication number
- CA3019256A1 CA3019256A1 CA3019256A CA3019256A CA3019256A1 CA 3019256 A1 CA3019256 A1 CA 3019256A1 CA 3019256 A CA3019256 A CA 3019256A CA 3019256 A CA3019256 A CA 3019256A CA 3019256 A1 CA3019256 A1 CA 3019256A1
- Authority
- CA
- Canada
- Prior art keywords
- flow
- desorption
- solvent
- desorption chamber
- flow injector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002470 solid-phase micro-extraction Methods 0.000 title claims abstract description 90
- 239000012491 analyte Substances 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims description 56
- 238000003795 desorption Methods 0.000 claims abstract description 269
- 239000012530 fluid Substances 0.000 claims abstract description 126
- 239000002904 solvent Substances 0.000 claims abstract description 94
- 239000007788 liquid Substances 0.000 claims abstract description 19
- 239000011800 void material Substances 0.000 claims abstract description 16
- 238000001514 detection method Methods 0.000 claims description 14
- 239000006199 nebulizer Substances 0.000 claims description 13
- 238000012546 transfer Methods 0.000 claims description 13
- 238000011010 flushing procedure Methods 0.000 claims description 11
- 230000000903 blocking effect Effects 0.000 claims description 5
- 238000009792 diffusion process Methods 0.000 claims description 5
- 238000001871 ion mobility spectroscopy Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 238000009616 inductively coupled plasma Methods 0.000 claims description 3
- 238000004611 spectroscopical analysis Methods 0.000 claims description 3
- 230000003287 optical effect Effects 0.000 claims 2
- 238000003825 pressing Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 45
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 14
- 239000007789 gas Substances 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 239000000835 fiber Substances 0.000 description 9
- 238000000576 coating method Methods 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 229960003920 cocaine Drugs 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000000523 sample Substances 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000002594 sorbent Substances 0.000 description 4
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 3
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 3
- 229960001736 buprenorphine Drugs 0.000 description 3
- STJMRWALKKWQGH-UHFFFAOYSA-N clenbuterol Chemical compound CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1 STJMRWALKKWQGH-UHFFFAOYSA-N 0.000 description 3
- 229960001117 clenbuterol Drugs 0.000 description 3
- 229960004126 codeine Drugs 0.000 description 3
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 3
- 229960002085 oxycodone Drugs 0.000 description 3
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 description 3
- 229960002073 sertraline Drugs 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000008055 phosphate buffer solution Substances 0.000 description 2
- 229920002239 polyacrylonitrile Polymers 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004885 tandem mass spectrometry Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical group C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G01N30/724—Nebulising, aerosol formation or ionisation
- G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/71—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
- G01N21/714—Sample nebulisers for flame burners or plasma burners
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1445—Overpressure, pressurisation at sampling point
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N2030/009—Extraction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N2030/062—Preparation extracting sample from raw material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
Abstract
L'invention concerne un système de désorption et de détection d'un analyte adsorbé sur un dispositif de microextraction en phase solide (SPME). Le système comprend une chambre de désorption dimensionnée de manière à accueillir le dispositif SPME tout en délimitant un volume vide inférieur à environ 50 µl; un injecteur de flux en communication fluidique avec la chambre de désorption, la chambre de désorption et l'injecteur de flux étant mis en communication fluidique par au moins un raccord de fluide à isolation de flux; une source de solvant en communication fluidique avec l'injecteur de flux; et un commutateur de fluide qui : dans une position de désorption, permet au solvant d'être pulvérisé par l'injecteur de flux tout en isolant du flux toute solution de désorption dans la chambre de désorption, et dans une position de détection, met hors circuit la source de solvant tout en maintenant la communication fluidique entre l'injecteur de flux et la chambre de désorption, transférant la solution de désorption à travers le raccord de fluide à isolation de flux vers l'injecteur de flux sous la forme d'un bouchon de liquide sensiblement non dilué.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662333934P | 2016-05-10 | 2016-05-10 | |
| US62/333,934 | 2016-05-10 | ||
| PCT/CA2017/050562 WO2017193213A1 (fr) | 2016-05-10 | 2017-05-10 | Système et procédé de désorption et de détection d'un analyte adsorbé sur un dispositif de microextraction en phase solide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3019256A1 true CA3019256A1 (fr) | 2017-11-16 |
Family
ID=60266052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3019256A Pending CA3019256A1 (fr) | 2016-05-10 | 2017-05-10 | Systeme et procede de desorption et de detection d'un analyte adsorbe sur un dispositif de microextraction en phase solide |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10429362B2 (fr) |
| EP (1) | EP3455870A4 (fr) |
| JP (1) | JP6803400B2 (fr) |
| CA (1) | CA3019256A1 (fr) |
| WO (1) | WO2017193213A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109844901B (zh) * | 2016-10-14 | 2022-06-14 | Dh科技发展私人贸易有限公司 | 提高用于质谱分析的直接取样接口灵敏度的方法和系统 |
| CN112640032A (zh) * | 2018-07-17 | 2021-04-09 | Dh科技发展私人贸易有限公司 | 开放端口探头接口 |
| WO2022113053A1 (fr) * | 2020-11-30 | 2022-06-02 | Dh Technologies Development Pte. Ltd. | Système d'échantillonnage pour une sonde à orifice ouvert |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140653A (en) | 1975-09-30 | 1979-02-20 | Toyo Soda Manufacturing Co., Ltd. | Solid support for liquid chromatography |
| US4476231A (en) | 1981-07-22 | 1984-10-09 | International Remote Imaging Systems, Inc. | Method of analyzing the distribution of a reagent between particles and liquid in a suspension |
| US4616652A (en) | 1983-10-19 | 1986-10-14 | Advanced Cardiovascular Systems, Inc. | Dilatation catheter positioning apparatus |
| US5120510A (en) | 1986-10-10 | 1992-06-09 | Minnesota Mining And Manufacturing Company | Sensor and method for sensing the concentration of a component in a medium |
| US5047437A (en) | 1988-11-23 | 1991-09-10 | American Cyanamid | Porous polyacrylonitrile beads and process for their production |
| US5081871A (en) | 1989-02-02 | 1992-01-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Breath sampler |
| US5691206A (en) | 1990-04-02 | 1997-11-25 | Pawliszyn; Janusz B. | Method and device for solid phase microextraction and desorption |
| GB9007356D0 (en) | 1990-04-02 | 1990-05-30 | Pawliszyn Janusz B | Micro solid phase extraction with fused silica optical fibres |
| US6042787A (en) * | 1990-02-04 | 2000-03-28 | Pawliszyn; Janusz B. | Device for solid phase microextraction and desorption |
| US5424187A (en) | 1991-06-14 | 1995-06-13 | Board Of Regents Of The University Of Washington | Method of screening for arterial chlamydial granuloma |
| FI96379C (fi) | 1992-10-16 | 1996-06-25 | Instrumentarium Oy | Menetelmä ja laitteisto näytteen analysoimiseksi |
| US5460813A (en) | 1993-04-05 | 1995-10-24 | National Jewish Center For Immunology And Respiratory Medicine | Method for treating Kawasaki syndrome by administration of an anti-TSST-1 agent which is not gamma globulin |
| DE69432791T2 (de) | 1993-05-28 | 2004-06-03 | Baylor College Of Medicine, Houston | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| US5464395A (en) | 1994-04-05 | 1995-11-07 | Faxon; David P. | Catheter for delivering therapeutic and/or diagnostic agents to the tissue surrounding a bodily passageway |
| US5640470A (en) | 1995-03-27 | 1997-06-17 | Abbott Laboratories | Fiber-optic detectors with terpolymeric analyte-permeable matrix coating |
| US5693228A (en) | 1995-09-28 | 1997-12-02 | Varian Associates, Inc. | Method and device for vibration during solid phase microextraction |
| US6750031B1 (en) | 1996-01-11 | 2004-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Displacement assay on a porous membrane |
| US5830184A (en) | 1996-03-06 | 1998-11-03 | Medical Components, Inc. | Composite catheter stabilizing devices, methods of making the same and catheter extracting device |
| US5808300A (en) | 1996-05-10 | 1998-09-15 | Board Of Regents, The University Of Texas System | Method and apparatus for imaging biological samples with MALDI MS |
| US6103535A (en) | 1996-05-31 | 2000-08-15 | University Of Maryland | Optical fiber evanescent field excited fluorosensor and method of manufacture |
| US5798266A (en) | 1996-08-27 | 1998-08-25 | K-Quay Enterprises, Llc | Methods and kits for obtaining and assaying mammary fluid samples for breast diseases, including cancer |
| US6743180B1 (en) | 1997-08-15 | 2004-06-01 | Rijksuniversiteit Leiden | Pressure sensor for use in an artery |
| JP3481828B2 (ja) | 1997-08-26 | 2003-12-22 | 株式会社日立製作所 | 電気泳動分析装置，電気泳動分析方法及びそれに用いる試料容器 |
| US6360588B1 (en) | 1998-10-27 | 2002-03-26 | Edward Allan Ross | Materials and methods for the analysis of substances passing through a membrane |
| DE19905239B4 (de) | 1999-02-02 | 2006-08-24 | Wendt, Oliver, Dipl.-Ing. | Positioniereinrichtung zur Positionierung von medizinischen Werkzeugen zur MR-gestützten Untersuchung und Behandlung von Körperteilen |
| EP1161223A4 (fr) * | 1999-03-02 | 2002-07-24 | Shaw Mudge & Company | Compositions de parfums et de saveurs contenant des agents d'elimination d'odeurs |
| US6815216B2 (en) | 1999-03-26 | 2004-11-09 | Gerstel Systemtechnik Gmbh & Co. Kg | Method for solid-phase microextraction and analysis, and a collector for this method |
| KR20020022653A (ko) | 1999-04-29 | 2002-03-27 | 사이퍼젠 바이오시스템스, 인코오포레이티드 | 기체상 질량 분광계용 소수성 코팅을 구비한 샘플 홀더 |
| US6167297A (en) | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
| US6905031B1 (en) | 1999-09-13 | 2005-06-14 | The Regents Of The University Of California | Solid phase microextraction device using aerogel |
| GB0006046D0 (en) | 2000-03-13 | 2000-05-03 | Univ Warwick | Time of flight mass spectrometry apparatus |
| ES2223814T3 (es) | 2000-03-17 | 2005-03-01 | Alain Pompidou | Dispositivo de analisis y/o de tratamiento con un vastago flexible. |
| US6651124B1 (en) | 2000-04-28 | 2003-11-18 | Hewlett-Packard Development Company, L.P. | Method and apparatus for preventing deadlock in a distributed shared memory system |
| AU2001278133A1 (en) | 2000-08-01 | 2002-02-13 | Surromed, Inc. | Methods for solid phase nanoextraction and desorption |
| US20040005582A1 (en) | 2000-08-10 | 2004-01-08 | Nanobiodynamics, Incorporated | Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators |
| WO2002025268A1 (fr) * | 2000-09-25 | 2002-03-28 | Gl Sciences Incorporated | Procede et dispositif servant a recueillir et a concentrer un echantillon |
| US6625433B1 (en) | 2000-09-29 | 2003-09-23 | Agere Systems Inc. | Constant compression automatic gain control circuit |
| JP4520621B2 (ja) * | 2000-11-01 | 2010-08-11 | 信和化工株式会社 | クロマトグラフィー用分離カラム、固相抽出用媒体、及びクロマトグラフィーの試料注入システム |
| US6498927B2 (en) | 2001-03-28 | 2002-12-24 | Gct Semiconductor, Inc. | Automatic gain control method for highly integrated communication receiver |
| US7468281B2 (en) | 2001-04-26 | 2008-12-23 | Varian, Inc. | Hollow fiber membrane sample preparation devices |
| US6816607B2 (en) | 2001-05-16 | 2004-11-09 | Siemens Corporate Research, Inc. | System for modeling static and dynamic three dimensional anatomical structures by 3-D models |
| US20020182746A1 (en) * | 2001-05-31 | 2002-12-05 | Zoltan Mester | Method and device for sample introduction of volatile analytes |
| US20040191537A1 (en) * | 2001-06-13 | 2004-09-30 | Dieter Lubda | Restricted access material for spme |
| US6871556B2 (en) | 2001-07-27 | 2005-03-29 | The Regents Of The University Of California | Porous protective solid phase micro-extractor sheath |
| WO2003046517A1 (fr) | 2001-11-26 | 2003-06-05 | Pawliszyn Janusz B | Dispositif et procede de micro-extraction et desorption de sorbant |
| US20030135195A1 (en) | 2002-01-16 | 2003-07-17 | Oscar Jimenez | Highly lubricious hydrophilic coating utilizing dendrimers |
| WO2003076927A1 (fr) | 2002-03-05 | 2003-09-18 | North Carolina State University | Procede et appareil pour determiner un descripteur moleculaire d'absorption pour un candidat compose |
| US7232689B2 (en) | 2002-03-11 | 2007-06-19 | Pawliszyn Janusz B | Calibration procedure for investigating biological systems |
| US9733234B2 (en) | 2002-03-11 | 2017-08-15 | Jp Scientific Limited | Probe for extraction of molecules of interest from a sample |
| ATE416675T1 (de) * | 2002-03-11 | 2008-12-15 | Janusz B Pawliszyn | Mikrovorrichtungen zur untersuchung von biologischen systemen |
| US7259019B2 (en) * | 2002-03-11 | 2007-08-21 | Pawliszyn Janusz B | Multiple sampling device and method for investigating biological systems |
| US8598325B2 (en) | 2002-03-11 | 2013-12-03 | Janusz B. Pawliszyn | Solid-phase microextraction coatings and methods for their preparation |
| US20090026122A1 (en) | 2002-03-11 | 2009-01-29 | Janusz | Biocompatible solid-phase microextraction coatings and methods for their preparation |
| US9870907B2 (en) | 2002-03-11 | 2018-01-16 | Jp Scientific Limited | Probe for extraction of molecules of interest from a sample |
| US7151167B2 (en) | 2002-06-10 | 2006-12-19 | Phynexus, Inc. | Open channel solid phase extraction systems and methods |
| US7122640B2 (en) | 2002-06-10 | 2006-10-17 | Phynexus, Inc. | Open channel solid phase extraction systems and methods |
| JP4521271B2 (ja) | 2002-06-28 | 2010-08-11 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 変形可能な３次元対象の頭頂の動きに関する情報を表示する画像処理システム |
| KR20110019357A (ko) | 2002-08-06 | 2011-02-25 | 더 존스 홉킨스 유니버시티 | 난소암의 검출을 위한 생물 마커의 용도 |
| US7460589B2 (en) | 2002-10-08 | 2008-12-02 | Broadcom Corporation | Eye monitoring and reconstruction using CDR and sub-sampling ADC |
| US7537803B2 (en) | 2003-04-08 | 2009-05-26 | New Jersey Institute Of Technology | Polymer coating/encapsulation of nanoparticles using a supercritical antisolvent process |
| US6891156B2 (en) | 2003-04-30 | 2005-05-10 | Perkin Elmer Instruments Llc | Sample plate for matrix-assisted laser desorption and ionization mass spectrometry |
| US20040241721A1 (en) | 2003-05-08 | 2004-12-02 | Gjerde Douglas T. | Open channel solid phase extraction systems and methods |
| US7667010B2 (en) | 2003-11-18 | 2010-02-23 | Phynexus, Inc. | Open channel solid phase extraction systems and methods |
| US8362219B2 (en) | 2003-05-08 | 2013-01-29 | Phynexus, Inc. | Open channel solid phase extraction systems and methods |
| CN2630850Y (zh) * | 2003-07-15 | 2004-08-04 | 武汉大学 | 固相微萃取与液相色谱联用装置 |
| WO2005033663A2 (fr) | 2003-09-30 | 2005-04-14 | Sequenom, Inc. | Procedes de fabrication de substrats pour analyse par spectrometrie de masse et dispositifs associes |
| US20050112650A1 (en) | 2003-10-20 | 2005-05-26 | Ciphergen Biosystems, Inc. | Reactive polyurethane-based polymers |
| US7981362B2 (en) | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
| US7030373B2 (en) | 2003-12-19 | 2006-04-18 | Applera Corporation | MALDI plate construction with grid |
| WO2005063977A1 (fr) | 2003-12-25 | 2005-07-14 | Riken | Procede d'amplification d'acides nucleiques et procede de detection d'acides nucleiques mutes l'utilisant |
| US7110724B1 (en) | 2004-12-16 | 2006-09-19 | Rf Micro Devices, Inc. | System and method for detecting compression of a power amplifier circuit |
| US7822246B2 (en) | 2004-12-20 | 2010-10-26 | Koninklijke Philips Electronics N.V. | Method, a system and a computer program for integration of medical diagnostic information and a geometric model of a movable body |
| US8399055B2 (en) | 2005-07-21 | 2013-03-19 | Rania Bakry | Open channel solid phase extraction systems and methods |
| US20080023630A1 (en) | 2005-11-22 | 2008-01-31 | Ciphergen Biosystems Inc. | Polymer probe doped with conductive material for mass spectrometry |
| US7738605B2 (en) | 2005-12-23 | 2010-06-15 | Agere Systems Inc. | Method and apparatus for adjusting receiver gain based on received signal envelope detection |
| US9108217B2 (en) | 2006-01-31 | 2015-08-18 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
| US7570934B2 (en) | 2006-04-18 | 2009-08-04 | Analog Devices, Inc. | Automatic gain control circuit |
| JP2009539114A (ja) | 2006-05-26 | 2009-11-12 | イオンセンス インコーポレイテッド | 表面イオン化技術で用いるための固体を保持する器具 |
| US20080193772A1 (en) | 2006-07-07 | 2008-08-14 | Bio-Rad Laboratories, Inc | Mass spectrometry probes having hydrophobic coatiings |
| US7778617B2 (en) | 2007-03-30 | 2010-08-17 | Broadcom Corporation | Three stage algorithm for automatic gain control in a receiver system |
| US8137979B2 (en) | 2007-06-25 | 2012-03-20 | Qinetiq Limited | Preconcentrator device |
| US20100130796A1 (en) | 2007-06-25 | 2010-05-27 | Combes David J | Heater suitable for use in a preconcentrator device |
| US20090058531A1 (en) | 2007-08-31 | 2009-03-05 | Nanoamp Solutions Inc. (Cayman) | Variable gain amplifier |
| US8150119B2 (en) | 2008-01-24 | 2012-04-03 | Siemens Aktiengesellschaft | Method and system for left ventricle endocardium surface segmentation using constrained optimal mesh smoothing |
| CN101971213A (zh) | 2008-02-29 | 2011-02-09 | 新加坡科技研究局 | 图像中解剖结构分割与建模的方法及系统 |
| US8620233B2 (en) | 2008-04-11 | 2013-12-31 | Samsung Electroncs Co., Ltd. | Method of power amplifier predistortion adaptation using compression detection |
| US8148161B2 (en) | 2008-05-02 | 2012-04-03 | The United States Of America, As Represented By The Secretary Of The Navy | Selective membranes/thin films for analytical applications |
| US20090317916A1 (en) | 2008-06-23 | 2009-12-24 | Ewing Kenneth J | Chemical sample collection and detection device using atmospheric pressure ionization |
| US20100249591A1 (en) | 2009-03-24 | 2010-09-30 | Andreas Heimdal | System and method for displaying ultrasound motion tracking information |
| US8494236B2 (en) | 2009-10-07 | 2013-07-23 | Siemens Aktiengesellschaft | System and method for cardiac segmentation in MR-cine data using inverse consistent non-rigid registration |
| US8364033B2 (en) | 2009-12-08 | 2013-01-29 | Telcordia Technologies, Inc. | Differential eye diagrams |
| US8843094B2 (en) | 2010-07-01 | 2014-09-23 | Broadcom Corporation | Method and system for blocker detecton and automatic gain control |
| US10321892B2 (en) | 2010-09-27 | 2019-06-18 | Siemens Medical Solutions Usa, Inc. | Computerized characterization of cardiac motion in medical diagnostic ultrasound |
| US20120160038A1 (en) * | 2010-12-22 | 2012-06-28 | Agilent Technologies, Inc. | Large-area solid phase extraction apparatus and methods |
| US8822949B2 (en) | 2011-02-05 | 2014-09-02 | Ionsense Inc. | Apparatus and method for thermal assisted desorption ionization systems |
| EP2699907A1 (fr) | 2011-04-19 | 2014-02-26 | Porex Corporation | Plaquettes de stockage et d'introduction d'échantillons constituées de plastique poreux fritté |
| CN102890824B (zh) | 2011-07-19 | 2015-07-29 | 株式会社东芝 | 运动对象轮廓跟踪方法和装置 |
| US8879815B2 (en) | 2011-08-23 | 2014-11-04 | Siemens Aktiengesellschaft | Automatic initialization for 2D/3D registration |
| FR2988620B1 (fr) * | 2012-03-29 | 2014-04-25 | Commissariat Energie Atomique | Dispositif et procede d'extraction de composes contenus dans un echantillon liquide en vue de leur analyse |
| CN102698720A (zh) | 2012-05-28 | 2012-10-03 | 河海大学 | 基于聚（甲基丙烯酸-乙二醇二甲基丙烯酸酯）的微固相萃取萃取探头的制备方法 |
| US20140040220A1 (en) | 2012-07-31 | 2014-02-06 | Hideaki Kimura | Methods and systems for deadlock detection |
| CN102847524A (zh) | 2012-09-21 | 2013-01-02 | 厦门大学 | 用于丙烯酰胺检测的固相微萃取萃取头及制备方法与应用 |
| US9268695B2 (en) | 2012-12-12 | 2016-02-23 | Avago Technologies General Ip (Singapore) Pte. Ltd. | Methods and structure for using region locks to divert I/O requests in a storage controller having multiple processing stacks |
| WO2015108969A1 (fr) | 2014-01-14 | 2015-07-23 | 908 Devices Inc. | Collecte d'échantillons dans des systèmes compacts de spectrométrie de masse |
| US9337007B2 (en) | 2014-06-15 | 2016-05-10 | Ionsense, Inc. | Apparatus and method for generating chemical signatures using differential desorption |
-
2017
- 2017-05-10 CA CA3019256A patent/CA3019256A1/fr active Pending
- 2017-05-10 EP EP17795219.9A patent/EP3455870A4/fr active Pending
- 2017-05-10 WO PCT/CA2017/050562 patent/WO2017193213A1/fr unknown
- 2017-05-10 JP JP2018558400A patent/JP6803400B2/ja active Active
-
2018
- 2018-10-16 US US16/162,034 patent/US10429362B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019521320A (ja) | 2019-07-25 |
| US10429362B2 (en) | 2019-10-01 |
| WO2017193213A1 (fr) | 2017-11-16 |
| EP3455870A4 (fr) | 2019-12-11 |
| JP6803400B2 (ja) | 2020-12-23 |
| US20190049415A1 (en) | 2019-02-14 |
| EP3455870A1 (fr) | 2019-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20170241877A1 (en) | System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device | |
| US10429362B2 (en) | System and method for desorbing and detecting an analyte sorbed on a solid phase microextraction device | |
| US11817302B2 (en) | Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis | |
| US10309928B2 (en) | Apparatus and method for ion mobility spectrometry and sample introduction | |
| US20100282962A1 (en) | Introduction of additives for an ionization interface at atmospheric pressure at the input to a spectrometer | |
| JP6423878B2 (ja) | 液体サンプルのための増大された噴霧形成 | |
| JPS583592B2 (ja) | 質量分析計への試料導入方法及び装置 | |
| JP2017504024A (ja) | 液体をイオン源に送達するためのシステムおよび方法 | |
| US11002715B2 (en) | Method for liquid chromatographic mass spectrometry and liquid chromatograph mass spectrometer | |
| JP2016532263A (ja) | 質量分析計供給源中への液体流れからの気泡除去 | |
| JP2019521320A5 (fr) | ||
| JPH06308087A (ja) | パーティクル・発生器および液体クロマトグラフ／質量分析計システム | |
| JP6801794B2 (ja) | 液体クロマトグラフ | |
| JP7142374B2 (ja) | 気相成分分析装置及び気相成分分析方法 | |
| US20210405000A1 (en) | Gas phase component analysis device and gas phase component analysis method | |
| US20160341696A1 (en) | Ion Mobility Spectrometer | |
| CN108027347B (zh) | 离子分析装置 | |
| JPH0961413A (ja) | キャピラリ−パイプの洗浄方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |
|
| EEER | Examination request |
Effective date: 20200205 |