CA3011663C - 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof - Google Patents
5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof Download PDFInfo
- Publication number
- CA3011663C CA3011663C CA3011663A CA3011663A CA3011663C CA 3011663 C CA3011663 C CA 3011663C CA 3011663 A CA3011663 A CA 3011663A CA 3011663 A CA3011663 A CA 3011663A CA 3011663 C CA3011663 C CA 3011663C
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- Prior art keywords
- mrna
- phosphorothiolate
- cap
- cap analog
- deoxy
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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| PCT/IB2017/050447 WO2017130151A1 (en) | 2016-01-29 | 2017-01-27 | 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof |
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| CA3011663A1 CA3011663A1 (en) | 2017-08-03 |
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| DE112020002327T5 (de) * | 2019-05-10 | 2022-07-14 | New England Biolabs, Inc. | Chemisches verkappen für matrizenwechsel |
| CN110907358B (zh) * | 2019-12-09 | 2022-08-30 | 福建师范大学 | 一种光微流微泡腔铅离子传感器的实现装置及方法 |
| PL432884A1 (pl) * | 2020-02-12 | 2021-08-16 | Uniwersytet Warszawski | Nowe analogi kapu końca 5' mRNA, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA i peptydu |
| CN113278665A (zh) * | 2020-08-20 | 2021-08-20 | 深圳市瑞吉生物科技有限公司 | 一种Cap2结构5′帽子类似物及其制备方法和应用 |
| WO2022051677A1 (en) | 2020-09-04 | 2022-03-10 | Verve Therapeutics, Inc. | Compositions and methods for capping rnas |
| CN119137271A (zh) * | 2022-03-01 | 2024-12-13 | 维乎医疗有限公司 | 用于加帽rna的组合物和方法 |
| CN114685588B (zh) * | 2022-05-05 | 2024-03-29 | 江苏申基生物科技有限公司 | 一种含开环核苷结构的起始加帽寡核苷酸引物 |
| CN116143855B (zh) * | 2022-11-08 | 2023-11-28 | 江苏申基生物科技有限公司 | 一种乙烯基膦酸修饰的mRNA帽类似物及其制备方法和应用 |
| EP4464713A1 (en) | 2023-05-18 | 2024-11-20 | Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii | Circular rna analogs, preparation and application thereof |
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| JP2008546424A (ja) * | 2005-06-28 | 2008-12-25 | アジェンコート パーソナル ジェノミクス コーポレイション | 修飾ポリヌクレオチドを作製する方法および配列決定する方法 |
| SI2167523T1 (sl) * | 2007-06-19 | 2014-09-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Sinteza in uporaba anti-reverznih fosforotioatnih analogov kape obveščevalne RNA |
| PL215513B1 (pl) * | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| EP2281579A1 (en) * | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| JP6567494B2 (ja) * | 2013-03-14 | 2019-08-28 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ４’−チオ−修飾ヌクレオチドを有するリボ核酸及び関連方法 |
| RS59991B1 (sr) * | 2013-08-08 | 2020-04-30 | Scripps Research Inst | Metoda enzimskog in vitro obeležavanja specifičnog za položaj nukleinskih kiselina uvođenjem neprirodnih nukleotida |
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| EP3408276A1 (en) | 2018-12-05 |
| CN109071589A (zh) | 2018-12-21 |
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| ES2879802T3 (es) | 2021-11-23 |
| JP7144050B2 (ja) | 2022-09-29 |
| CA3011663A1 (en) | 2017-08-03 |
| AU2017211693B2 (en) | 2021-09-09 |
| JP2019504837A (ja) | 2019-02-21 |
| US20190300563A1 (en) | 2019-10-03 |
| AU2017211693A1 (en) | 2018-08-09 |
| KR20180100595A (ko) | 2018-09-11 |
| EP3408276B1 (en) | 2021-04-07 |
| PL3408276T3 (pl) | 2021-10-25 |
| EA201891429A1 (ru) | 2019-02-28 |
| PL415967A1 (pl) | 2017-07-31 |
| US11066436B2 (en) | 2021-07-20 |
| EA038834B1 (ru) | 2021-10-26 |
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