EA038834B1 - 5'-фосфоротиоатные аналоги 5'-конца (кэпа) мрнк, содержащая их мрнк, способ их получения и применение - Google Patents
5'-фосфоротиоатные аналоги 5'-конца (кэпа) мрнк, содержащая их мрнк, способ их получения и применение Download PDFInfo
- Publication number
- EA038834B1 EA038834B1 EA201891429A EA201891429A EA038834B1 EA 038834 B1 EA038834 B1 EA 038834B1 EA 201891429 A EA201891429 A EA 201891429A EA 201891429 A EA201891429 A EA 201891429A EA 038834 B1 EA038834 B1 EA 038834B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- deoxy
- mrna
- thioguanosine
- methyl
- cap
- Prior art date
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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Landscapes
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| PL415967A PL415967A1 (pl) | 2016-01-29 | 2016-01-29 | 5'-tiofosforanowe analogi końca 5' mRNA (kapu), sposób ich otrzymywania i zastosowanie |
| PCT/IB2017/050447 WO2017130151A1 (en) | 2016-01-29 | 2017-01-27 | 5'-phosphorothiolate mrna 5'-end (cap) analogs, mrna comprising the same, method of obtaining and uses thereof |
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| EA201891429A1 EA201891429A1 (ru) | 2019-02-28 |
| EA038834B1 true EA038834B1 (ru) | 2021-10-26 |
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| DE112020002327T5 (de) * | 2019-05-10 | 2022-07-14 | New England Biolabs, Inc. | Chemisches verkappen für matrizenwechsel |
| CN110907358B (zh) * | 2019-12-09 | 2022-08-30 | 福建师范大学 | 一种光微流微泡腔铅离子传感器的实现装置及方法 |
| PL432884A1 (pl) * | 2020-02-12 | 2021-08-16 | Uniwersytet Warszawski | Nowe analogi kapu końca 5' mRNA, cząsteczka RNA je zawierająca, ich zastosowania i sposób syntezy cząsteczki RNA i peptydu |
| CN113234780A (zh) * | 2020-08-20 | 2021-08-10 | 深圳市瑞吉生物科技有限公司 | 一种Cap2结构5′帽子类似物及其制备方法和应用 |
| CN116368226A (zh) | 2020-09-04 | 2023-06-30 | 维乎医疗有限公司 | 用于加帽rna的组合物和方法 |
| WO2023167880A2 (en) * | 2022-03-01 | 2023-09-07 | Verve Therapeutics, Inc. | Compositions and methods for capping rnas |
| CN114685588B (zh) * | 2022-05-05 | 2024-03-29 | 江苏申基生物科技有限公司 | 一种含开环核苷结构的起始加帽寡核苷酸引物 |
| CN116143855B (zh) * | 2022-11-08 | 2023-11-28 | 江苏申基生物科技有限公司 | 一种乙烯基膦酸修饰的mRNA帽类似物及其制备方法和应用 |
| EP4464713A1 (en) | 2023-05-18 | 2024-11-20 | Siec Badawcza Lukasiewicz - PORT Polski Osrodek Rozwoju Technologii | Circular rna analogs, preparation and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008157688A2 (en) * | 2007-06-19 | 2008-12-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| WO2009149253A2 (en) * | 2008-06-06 | 2009-12-10 | Uniwersytet Warszawski | Mrna cap analogs |
| EP2281579A1 (en) * | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
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| JP2008546424A (ja) | 2005-06-28 | 2008-12-25 | アジェンコート パーソナル ジェノミクス コーポレイション | 修飾ポリヌクレオチドを作製する方法および配列決定する方法 |
| EP2970351B1 (en) * | 2013-03-14 | 2017-09-13 | Translate Bio, Inc. | Ribonucleic acids with 4'-thio-modified nucleotides and related methods |
| HRP20200250T1 (hr) | 2013-08-08 | 2020-05-29 | The Scripps Research Institute | Metoda site-specifično enzimsko obilježavanje nukleinskih kiselina in vitro ugradnjom neprirodnih nukleotida |
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- 2017-01-27 CA CA3011663A patent/CA3011663C/en active Active
- 2017-01-27 WO PCT/IB2017/050447 patent/WO2017130151A1/en not_active Ceased
- 2017-01-27 PL PL17712541T patent/PL3408276T3/pl unknown
- 2017-01-27 CN CN201780013350.3A patent/CN109071589A/zh active Pending
- 2017-01-27 EA EA201891429A patent/EA038834B1/ru unknown
- 2017-01-27 JP JP2018537845A patent/JP7144050B2/ja active Active
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- 2017-01-27 US US16/073,499 patent/US11066436B2/en active Active
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| WO2008157688A2 (en) * | 2007-06-19 | 2008-12-24 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| WO2009149253A2 (en) * | 2008-06-06 | 2009-12-10 | Uniwersytet Warszawski | Mrna cap analogs |
| EP2281579A1 (en) * | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
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| ANNA WYPIJEWSKA DEL NOGAL, MARIUS D. SURLEAC, JOANNA KOWALSKA, MACIEJ LUKASZEWICZ, JACEK JEMIELITY, MARTIN BISAILLON, EDWARD DARZY: "Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding", THE FEBS JOURNAL, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 280, no. 24, 23 December 2013 (2013-12-23), GB , pages 6508 - 6527, XP055367414, ISSN: 1742-464X, DOI: 10.1111/febs.12553 * |
| JOANNA KOWALSKA, MAGDALENA LEWDOROWICZ, JOANNA ZUBEREK, EWA GRUDZIEN-NOGALSKA, ELZBIETA BOJARSKA, JANUSZ STEPINSKI, ROBERT E. RHOA: "Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS", RNA, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 14, no. 6, 1 June 2008 (2008-06-01), US , pages 1119 - 1131, XP002554206, ISSN: 1355-8382, DOI: 10.1261/rna.990208 * |
Also Published As
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| AU2017211693B2 (en) | 2021-09-09 |
| US20190300563A1 (en) | 2019-10-03 |
| CA3011663A1 (en) | 2017-08-03 |
| JP2019504837A (ja) | 2019-02-21 |
| EP3408276B1 (en) | 2021-04-07 |
| AU2017211693A1 (en) | 2018-08-09 |
| ES2879802T3 (es) | 2021-11-23 |
| JP7144050B2 (ja) | 2022-09-29 |
| US11066436B2 (en) | 2021-07-20 |
| CA3011663C (en) | 2023-10-31 |
| KR102742219B1 (ko) | 2024-12-13 |
| EA201891429A1 (ru) | 2019-02-28 |
| EP3408276A1 (en) | 2018-12-05 |
| CN109071589A (zh) | 2018-12-21 |
| PL415967A1 (pl) | 2017-07-31 |
| WO2017130151A1 (en) | 2017-08-03 |
| PL3408276T3 (pl) | 2021-10-25 |
| KR20180100595A (ko) | 2018-09-11 |
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