CA3010678A1 - Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy - Google Patents

Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy Download PDF

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Publication number
CA3010678A1
CA3010678A1 CA3010678A CA3010678A CA3010678A1 CA 3010678 A1 CA3010678 A1 CA 3010678A1 CA 3010678 A CA3010678 A CA 3010678A CA 3010678 A CA3010678 A CA 3010678A CA 3010678 A1 CA3010678 A1 CA 3010678A1
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Prior art keywords
potency
enhancing
compositions
methods
cancer immunotherapy
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CA3010678A
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English (en)
French (fr)
Inventor
Asher Nathan
Michal Shahar
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Neotx Therapeutics Ltd
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Neotx Therapeutics Ltd
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    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
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  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3010678A 2016-01-10 2017-01-10 Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy Pending CA3010678A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662276955P 2016-01-10 2016-01-10
US62/276,955 2016-01-10
PCT/IB2017/000511 WO2017122098A2 (en) 2016-01-10 2017-01-10 Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy.

Publications (1)

Publication Number Publication Date
CA3010678A1 true CA3010678A1 (en) 2017-07-20

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Application Number Title Priority Date Filing Date
CA3010678A Pending CA3010678A1 (en) 2016-01-10 2017-01-10 Methods and compositions for enhancing the potency of superantigen mediated cancer immunotherapy

Country Status (13)

Country Link
US (4) US10314910B2 (https=)
EP (1) EP3411409B1 (https=)
JP (1) JP7161938B2 (https=)
KR (2) KR20250071286A (https=)
CN (2) CN117679499A (https=)
AU (1) AU2017206656B2 (https=)
CA (1) CA3010678A1 (https=)
EA (1) EA201891601A1 (https=)
ES (1) ES3052659T3 (https=)
IL (1) IL260423B2 (https=)
MX (1) MX2018008383A (https=)
WO (1) WO2017122098A2 (https=)
ZA (1) ZA201804565B (https=)

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AU2017206656B2 (en) 2016-01-10 2024-02-01 Neotx Therapeutics Ltd. Immunopotentiator enhanced superantigen mediated cancer immunotherapy
JP7536295B2 (ja) * 2018-05-16 2024-08-20 デューク ユニバーシティ 免疫毒素とチェックポイント阻害剤との組み合わせを用いるネオアジュバントがん処置
CN108840923B (zh) * 2018-06-22 2021-08-03 上海交通大学医学院附属仁济医院 一种靶向pd-l1的多肽及其应用
AU2020275142A1 (en) * 2019-05-15 2021-12-16 Neotx Therapeutics Ltd. Cancer treatment
WO2021087105A1 (en) 2019-10-30 2021-05-06 Duke University Immunotherapy with combination therapy comprising an immunotoxin
IL296103A (en) * 2020-03-05 2022-11-01 Neotx Therapeutics Ltd Methods and compositions for treating cancer with immune cells
US20230285588A1 (en) * 2020-07-20 2023-09-14 Neotx Therapeutics Ltd. Superantigen conjugate for use in methods and compositions for treating cancer
CN113527491B (zh) * 2020-08-19 2023-06-20 苏州易慕峰生物科技有限公司 人源化抗体、嵌合抗原受体、核酸、载体、细胞及应用
EP4326775A1 (en) * 2021-04-22 2024-02-28 Neotx Therapeutics Ltd. Methods and compositions for treating glioblastoma
EP4536278A2 (en) 2022-06-07 2025-04-16 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
CN116284448B (zh) * 2023-02-14 2024-06-21 浙江大学 一种超抗原参与的三功能t细胞衔接器及其应用

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