CA3005411C - Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 - Google Patents
Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 Download PDFInfo
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- CA3005411C CA3005411C CA3005411A CA3005411A CA3005411C CA 3005411 C CA3005411 C CA 3005411C CA 3005411 A CA3005411 A CA 3005411A CA 3005411 A CA3005411 A CA 3005411A CA 3005411 C CA3005411 C CA 3005411C
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- myd88
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Classifications
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Applications Claiming Priority (3)
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| US201562255878P | 2015-11-16 | 2015-11-16 | |
| US62/255,878 | 2015-11-16 | ||
| PCT/IB2016/001745 WO2017085550A1 (en) | 2015-11-16 | 2016-11-15 | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
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| CA3005411A1 CA3005411A1 (en) | 2017-05-26 |
| CA3005411C true CA3005411C (en) | 2024-01-09 |
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| EP (2) | EP3377630A4 (OSRAM) |
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| CN (1) | CN108699556B (OSRAM) |
| CA (1) | CA3005411C (OSRAM) |
| WO (1) | WO2017085550A1 (OSRAM) |
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| EP2631291B1 (en) | 2010-10-22 | 2019-05-15 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| KR101567576B1 (ko) | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도 |
| WO2017085550A1 (en) | 2015-11-16 | 2017-05-26 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| US10358648B2 (en) | 2016-02-02 | 2019-07-23 | Olix Pharmaceuticals, Inc. | Treatment of atopic dermatitis and asthma using RNA complexes that target IL4Rα, TRPA1, or F2RL1 |
| CN108779464B (zh) | 2016-02-02 | 2022-05-17 | 奥利克斯医药有限公司 | 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病 |
| KR102339886B1 (ko) | 2016-04-11 | 2021-12-17 | 올릭스 주식회사 | 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법 |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| WO2018146557A2 (en) | 2017-02-10 | 2018-08-16 | Dong Ki Lee | Long double-stranded rna for rna interference |
| WO2021241803A1 (ko) * | 2020-05-26 | 2021-12-02 | 올릭스 주식회사 | MyD88을 표적으로 하는 RNAi 제제 및 이의 용도 |
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| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US5837258A (en) | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| CN102180924A (zh) | 1999-05-04 | 2011-09-14 | 桑塔里斯制药公司 | L-核糖-lna类似物 |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| CZ302719B6 (cs) | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
| US20050282188A1 (en) | 2001-05-18 | 2005-12-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
| US20080188430A1 (en) | 2001-05-18 | 2008-08-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
| JP2005514005A (ja) | 2001-09-04 | 2005-05-19 | エクシコン エ／エス | 新規のｌｎａ組成物およびその使用 |
| WO2003035876A1 (de) | 2001-10-26 | 2003-05-01 | Ribopharma Ag | Verwendung einer doppelsträngigen ribonukleinsäure zur behandlung einer infektion mit einem (+)-strang-rna-virus |
| US20040138163A1 (en) | 2002-05-29 | 2004-07-15 | Mcswiggen James | RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| KR100464261B1 (ko) | 2002-01-24 | 2005-01-03 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| KR20030084444A (ko) | 2002-04-26 | 2003-11-01 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| DK1527176T4 (en) | 2002-08-05 | 2017-07-03 | Silence Therapeutics Gmbh | ADDITIONAL NEW FORMS OF INTERFERRING RNA MOLECULES |
| WO2006006948A2 (en) | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| EP1560931B1 (en) | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| EP2216407B1 (en) | 2003-03-07 | 2016-01-13 | Alnylam Pharmaceuticals, Inc. | Therapeutic compositions |
| US20040198640A1 (en) | 2003-04-02 | 2004-10-07 | Dharmacon, Inc. | Stabilized polynucleotides for use in RNA interference |
| US7211668B2 (en) | 2003-07-28 | 2007-05-01 | Panagene, Inc. | PNA monomer and precursor |
| US20050136437A1 (en) | 2003-08-25 | 2005-06-23 | Nastech Pharmaceutical Company Inc. | Nanoparticles for delivery of nucleic acids and stable double-stranded RNA |
| BRPI0413930A (pt) * | 2003-09-18 | 2006-10-24 | Isis Pharmaceuticals Inc | composto oligomérico ou sal farmaceuticamente aceitável deste, composição farmacêutica ou veterinária, métodos para inibir a expressão de eif4e em uma célula, tecido ou órgão, para diminuir a proliferação de uma célula em que eif4e é expressado, e para prevenir ou tratar uma condição ou doença métodos para prevenir ou diminuir a angiogênese, e o crescimento de tumor em um paciente, oligonucleotìdeo de anti-sentido, composição farmacêutica ou veterinária, e, uso de um composto oligomérico ou sal farmaceuticamente aceitável deste |
| US20060134787A1 (en) | 2004-12-22 | 2006-06-22 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA |
| WO2005062937A2 (en) | 2003-12-22 | 2005-07-14 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna |
| US20060069050A1 (en) | 2004-02-17 | 2006-03-30 | University Of Massachusetts | Methods and compositions for mediating gene silencing |
| WO2005087926A2 (en) | 2004-03-05 | 2005-09-22 | Benitec, Inc. | Multiple promoter expression cassettes for simultaneous delivery of rnai agents |
| EP2636739B1 (en) | 2004-03-12 | 2014-12-10 | Alnylam Pharmaceuticals Inc. | iRNA agents targeting VEGF |
| KR101147147B1 (ko) | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| JP2008512500A (ja) | 2004-09-10 | 2008-04-24 | ソマジェニックス インコーポレーティッド | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| NZ554214A (en) | 2004-09-24 | 2009-10-30 | Alnylam Pharmaceuticals Inc | Rnai modulation of apob and uses thereof |
| US20060142228A1 (en) | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| TWI386225B (zh) | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
| KR20070118703A (ko) | 2005-04-08 | 2007-12-17 | 나스텍 파마수티컬 컴퍼니 인코포레이티드 | 호흡기 바이러스 감염을 치료하는 알엔에이 아이 |
| EP1891216B1 (en) | 2005-05-25 | 2012-02-22 | The University Of York | Hybrid interfering rna |
| MX2007016083A (es) | 2005-06-24 | 2008-03-10 | Intervet Int Bv | Vacunas quimericas inactivadas y metodos relacionados de uso. |
| FR2890859B1 (fr) | 2005-09-21 | 2012-12-21 | Oreal | Oligonucleotide d'arn double brin inhibant l'expression de la tyrosinase |
| US7825099B2 (en) * | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| AU2007210034A1 (en) | 2006-01-26 | 2007-08-09 | University Of Massachusetts | RNA silencing agents for use in therapy and nanotransporters for efficient delivery of same |
| JP5829373B2 (ja) | 2006-01-27 | 2015-12-09 | バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． | Ｎｏｇｏレセプターアンタゴニスト |
| US20070218495A1 (en) | 2006-03-16 | 2007-09-20 | Dharmacon, Inc. | Methods, libraries and computer program products for gene silencing with reduced off-target effects |
| US7700541B2 (en) | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| GB0608838D0 (en) | 2006-05-04 | 2006-06-14 | Novartis Ag | Organic compounds |
| US20100105134A1 (en) | 2007-03-02 | 2010-04-29 | Mdrna, Inc. | Nucleic acid compounds for inhibiting gene expression and uses thereof |
| EP2121924A1 (en) | 2007-03-02 | 2009-11-25 | MDRNA, Inc. | Nucleic acid compounds for inhibiting vegf family gene expression and uses thereof |
| CA2691617C (en) | 2007-05-31 | 2020-07-21 | University Of Iowa Research Foundation | Reduction of off-target rna interference toxicity |
| US20090004668A1 (en) | 2007-06-22 | 2009-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Pre-miRNA loop-modulated target regulation |
| EP2319926B1 (en) * | 2007-07-05 | 2016-08-31 | Arrowhead Research Corporation | DSRNA for treating viral infection |
| EP2167135A2 (en) | 2007-07-12 | 2010-03-31 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| WO2009020344A2 (en) | 2007-08-06 | 2009-02-12 | Postech Acad Ind Found | Small interfering rnas (sirnas) controlling multiple target genes and method for preparing the same |
| ES2617877T3 (es) | 2007-08-27 | 2017-06-20 | 1Globe Health Institute Llc | Composiciones de ARN interferente asimétrico y uso de las mismas |
| DK2195428T3 (en) | 2007-09-19 | 2014-03-03 | Applied Biosystems Llc | SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF |
| US8614309B2 (en) | 2007-10-03 | 2013-12-24 | Quark Pharmaceuticals, Inc. | Double-stranded RNA directed to CASP2 and methods of use thereof |
| US20090131358A1 (en) | 2007-11-15 | 2009-05-21 | Alcon Research, Ltd. | LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED siRNA DELIVERY |
| US8614311B2 (en) | 2007-12-12 | 2013-12-24 | Quark Pharmaceuticals, Inc. | RTP801L siRNA compounds and methods of use thereof |
| KR100949791B1 (ko) | 2007-12-18 | 2010-03-30 | 이동기 | 오프-타겟 효과를 최소화하고 ＲＮＡｉ 기구를 포화시키지않는 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
| US8481508B2 (en) | 2008-02-21 | 2013-07-09 | University Of Kentucky Research Foundation | Ultra-small RNAs as toll-like receptor-3 antagonists |
| US8324366B2 (en) | 2008-04-29 | 2012-12-04 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for delivering RNAI using lipoproteins |
| CA2731779A1 (en) | 2008-07-24 | 2010-01-28 | Rxi Pharmaceuticals Corporation | Rnai constructs and uses therof |
| EP2341914A2 (en) * | 2008-08-04 | 2011-07-13 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 3 expression by antisense oligonucleotides |
| KR20110036966A (ko) | 2008-08-08 | 2011-04-12 | 이데라 파마슈티칼즈, 인코포레이티드 | 안티센스 올리고누클레오티드에 의한 골수 분화 일차 반응 유전자 ８８ （ｍｙｄ８８） 발현의 조절 |
| JP5294344B2 (ja) | 2008-09-08 | 2013-09-18 | 学校法人福岡大学 | 白血病治療用医薬組成物 |
| CA2753338A1 (en) | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Neutral nanotransporters |
| US20100227920A1 (en) | 2008-09-29 | 2010-09-09 | The Regents Of The University Of California | Aldehyde dehydrogenase inhibitors as novel depigmenting agents |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| JP2012517815A (ja) | 2009-02-18 | 2012-08-09 | サイレンス・セラピューティクス・アーゲー | Ａｎｇ２の発現を阻害するための手段 |
| JP2012520683A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いた結合組織増殖因子（ＣＴＧＦ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| ES2921573T3 (es) | 2009-04-03 | 2022-08-29 | Dicerna Pharmaceuticals Inc | Métodos y composiciones para la inhibición específica de KRAS por RNA bicatenario asimétrico |
| US8472766B2 (en) | 2009-08-14 | 2013-06-25 | Massachusetts Institute Of Technology | Waveguide coupler having continuous three-dimensional tapering |
| KR101207561B1 (ko) | 2009-12-15 | 2012-12-04 | 주식회사 코리아나화장품 | 티로시나제의 발현을 저해하는 ｓｉＲＮＡ 올리고뉴클레오타이드 및 이를 함유하는 화장료 조성물 |
| WO2011084193A1 (en) | 2010-01-07 | 2011-07-14 | Quark Pharmaceuticals, Inc. | Oligonucleotide compounds comprising non-nucleotide overhangs |
| NZ601737A (en) | 2010-02-24 | 2013-06-28 | Arrowhead Res Corp | Compositions for targeted delivery of sirna |
| EP3578183B1 (en) | 2010-03-24 | 2021-09-08 | Phio Pharmaceuticals Corp. | Rna interference in ocular indications |
| WO2011140659A1 (en) | 2010-05-12 | 2011-11-17 | Centre Hospitalier De L'universite De Montreal | Screening assays based on mag and/or abhd6 for selecting insulin secretion promoting agents |
| JP2013541334A (ja) | 2010-09-15 | 2013-11-14 | アルニラム ファーマスーティカルズ インコーポレイテッド | 修飾されたｉＲＮＡ剤 |
| EP2631291B1 (en) | 2010-10-22 | 2019-05-15 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| AU2011338682B2 (en) | 2010-12-06 | 2017-04-27 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising threose modifications |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| BR122020024394B1 (pt) | 2010-12-29 | 2021-05-11 | F. Hoffmann-La Roche Ag | conjugado e composição farmacêutica |
| SG193280A1 (en) * | 2011-03-03 | 2013-10-30 | Quark Pharmaceuticals Inc | Oligonucleotide modulators of the toll-like receptor pathway |
| CN102719432B (zh) | 2011-03-29 | 2013-10-23 | 南京大学 | 特异性抑制肿瘤凋亡抑制基因Bcl2的双链不对称小核酸干扰分子asiRNA及其应用 |
| KR101590586B1 (ko) | 2011-05-30 | 2016-02-01 | 성균관대학교산학협력단 | 표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ |
| AU2012284223B2 (en) | 2011-07-18 | 2017-06-22 | University Of Kentucky Research Foundation | Protection of cells from Alu-RNA-induced degenereation and inhibitors for protecting cells |
| US9707235B1 (en) | 2012-01-13 | 2017-07-18 | University Of Kentucky Research Foundation | Protection of cells from degeneration and treatment of geographic atrophy |
| CN111893117B (zh) | 2012-01-27 | 2024-06-04 | 比奥马林技术公司 | 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
| KR101567576B1 (ko) | 2012-05-22 | 2015-11-10 | 올릭스 주식회사 | 세포 내 관통능을 가지고 ｒｎａ 간섭을 유도하는 핵산 분자 및 그 용도 |
| US9611473B2 (en) * | 2012-09-12 | 2017-04-04 | Quark Pharmaceuticals, Inc. | Double-stranded nucleic acid compounds |
| JP2016525346A (ja) | 2013-07-05 | 2016-08-25 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 呼吸器疾患関連遺伝子特異的ｓｉＲＮＡ、そのようなｓｉＲＮＡを含む二重らせんオリゴＲＮＡ構造体およびこれを含む呼吸器疾患予防または治療用組成物 |
| WO2015015498A1 (en) * | 2013-07-31 | 2015-02-05 | Qbi Enterprises Ltd. | Methods of use of sphingolipid polyalkylamine oligonucleotide compounds |
| US9790506B2 (en) | 2013-10-02 | 2017-10-17 | The Regents Of The University Of California | Diagnostic and screening methods for atopic dermatitis |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| US20170226507A1 (en) | 2014-05-05 | 2017-08-10 | The Brigham And Women's Hospital, Inc. | Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases |
| US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
| JP6892433B2 (ja) | 2015-04-03 | 2021-06-23 | ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ | 十分に安定化された非対称ｓｉｒｎａ |
| JP7027303B2 (ja) | 2015-07-27 | 2022-03-01 | オリックス ファーマシューティカルズ，インコーポレーテッド | メラニン産生を抑制するｒｎａ複合体 |
| WO2017085550A1 (en) | 2015-11-16 | 2017-05-26 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| US10358648B2 (en) | 2016-02-02 | 2019-07-23 | Olix Pharmaceuticals, Inc. | Treatment of atopic dermatitis and asthma using RNA complexes that target IL4Rα, TRPA1, or F2RL1 |
| CN108779464B (zh) | 2016-02-02 | 2022-05-17 | 奥利克斯医药有限公司 | 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病 |
| CN105748782A (zh) * | 2016-02-25 | 2016-07-13 | 太和县中医院 | 一种用于治疗颈椎病的中药口服液 |
| KR102339886B1 (ko) | 2016-04-11 | 2021-12-17 | 올릭스 주식회사 | 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법 |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| WO2018146557A2 (en) | 2017-02-10 | 2018-08-16 | Dong Ki Lee | Long double-stranded rna for rna interference |
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| WO2017085550A1 (en) | 2017-05-26 |
| CN108699556B (zh) | 2023-02-17 |
| EP3377630A4 (en) | 2020-01-01 |
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| US20170137828A1 (en) | 2017-05-18 |
| CA3005411A1 (en) | 2017-05-26 |
| US10590423B2 (en) | 2020-03-17 |
| EP4454637A3 (en) | 2025-01-08 |
| CN108699556A (zh) | 2018-10-23 |
| JP2018533956A (ja) | 2018-11-22 |
| US10059949B2 (en) | 2018-08-28 |
| KR20180071362A (ko) | 2018-06-27 |
| KR102727666B1 (ko) | 2024-11-08 |
| EP3377630A1 (en) | 2018-09-26 |
| US20180327755A1 (en) | 2018-11-15 |
| JP7027311B2 (ja) | 2022-03-01 |
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