CA2995554A1 - Compose tetrahydrooxepinopyridine - Google Patents
Compose tetrahydrooxepinopyridine Download PDFInfo
- Publication number
- CA2995554A1 CA2995554A1 CA2995554A CA2995554A CA2995554A1 CA 2995554 A1 CA2995554 A1 CA 2995554A1 CA 2995554 A CA2995554 A CA 2995554A CA 2995554 A CA2995554 A CA 2995554A CA 2995554 A1 CA2995554 A1 CA 2995554A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- lower alkyl
- ring
- formula
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
L'invention vise à fournir un composé qui présente un effet de modulation allostérique positif (effet PAM) pour un récepteur nicotinique à l'acétylcholine a7 (récepteur nACh a7). Les inventeurs ont réalisé la présente invention en effectuant des études sur les effets PAM pour un récepteur nACh a7 et en confirmant qu'un composé tétrahydrooxépinopyridine présente un effet PAM pour un récepteur nACh a7. Un composé tétrahydrooxépinopyridine selon la présente invention présente un effet PAM pour un récepteur nACh a7, et est prometteur en tant qu'agent prophylactique ou thérapeutique pour la démence, une déficience cognitive, la schizophrénie, la maladie d'Alzheimer, les déficits cognitifs associés à la schizophrénie (CIAS, pour "cognitive impairment associated with schizophrenia"), les symptômes négatifs de la schizophrénie, les maladies inflammatoires ou la douleur.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015-162320 | 2015-08-19 | ||
JP2015162320 | 2015-08-19 | ||
PCT/JP2016/074145 WO2017030171A1 (fr) | 2015-08-19 | 2016-08-18 | Composé tétrahydrooxépinopyridine |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2995554A1 true CA2995554A1 (fr) | 2017-02-23 |
CA2995554C CA2995554C (fr) | 2023-06-27 |
Family
ID=58052257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2995554A Active CA2995554C (fr) | 2015-08-19 | 2016-08-18 | Compose tetrahydrooxepinopyridine |
Country Status (21)
Country | Link |
---|---|
US (1) | US9670219B2 (fr) |
EP (1) | EP3345909B1 (fr) |
JP (1) | JP6787320B2 (fr) |
KR (1) | KR102614279B1 (fr) |
CN (1) | CN107922426B (fr) |
AR (1) | AR105738A1 (fr) |
AU (1) | AU2016308406A1 (fr) |
CA (1) | CA2995554C (fr) |
CO (1) | CO2018002472A2 (fr) |
EA (1) | EA034794B1 (fr) |
ES (1) | ES2812246T3 (fr) |
HK (1) | HK1251574A1 (fr) |
IL (1) | IL257450A (fr) |
MX (1) | MX2018002118A (fr) |
PH (1) | PH12018500297A1 (fr) |
PL (1) | PL3345909T3 (fr) |
PT (1) | PT3345909T (fr) |
SG (1) | SG11201801193QA (fr) |
TW (1) | TW201722962A (fr) |
WO (1) | WO2017030171A1 (fr) |
ZA (1) | ZA201801098B (fr) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010020672A1 (fr) * | 2008-08-21 | 2010-02-25 | Neurosearch A/S | Nouveaux dérivés de phénylquinoléine-acide carboxylique-pyridine utiles comme modulateurs des récepteurs nicotiniques à l'acétylcholine |
GB201106829D0 (en) | 2011-04-21 | 2011-06-01 | Proximagen Ltd | Heterocyclic compounds |
MY161236A (en) | 2011-02-25 | 2017-04-14 | Janssen Pharmaceutica Nv | (pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nachr |
AR086791A1 (es) * | 2011-07-01 | 2014-01-22 | Lundbeck & Co As H | Moduladores alostericos positivos del receptor de acetilcolina nicotinico |
US20130005743A1 (en) * | 2011-07-01 | 2013-01-03 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
-
2016
- 2016-08-18 EP EP16837160.7A patent/EP3345909B1/fr active Active
- 2016-08-18 TW TW105126427A patent/TW201722962A/zh unknown
- 2016-08-18 SG SG11201801193QA patent/SG11201801193QA/en unknown
- 2016-08-18 PT PT168371607T patent/PT3345909T/pt unknown
- 2016-08-18 WO PCT/JP2016/074145 patent/WO2017030171A1/fr active Application Filing
- 2016-08-18 AU AU2016308406A patent/AU2016308406A1/en not_active Abandoned
- 2016-08-18 EA EA201890514A patent/EA034794B1/ru not_active IP Right Cessation
- 2016-08-18 JP JP2017535563A patent/JP6787320B2/ja active Active
- 2016-08-18 MX MX2018002118A patent/MX2018002118A/es active IP Right Grant
- 2016-08-18 AR ARP160102537A patent/AR105738A1/es unknown
- 2016-08-18 ES ES16837160T patent/ES2812246T3/es active Active
- 2016-08-18 CN CN201680048575.8A patent/CN107922426B/zh active Active
- 2016-08-18 KR KR1020187004555A patent/KR102614279B1/ko active IP Right Grant
- 2016-08-18 PL PL16837160T patent/PL3345909T3/pl unknown
- 2016-08-18 CA CA2995554A patent/CA2995554C/fr active Active
- 2016-09-07 US US15/258,241 patent/US9670219B2/en active Active
-
2018
- 2018-02-09 PH PH12018500297A patent/PH12018500297A1/en unknown
- 2018-02-11 IL IL257450A patent/IL257450A/en unknown
- 2018-02-16 ZA ZA2018/01098A patent/ZA201801098B/en unknown
- 2018-03-06 CO CONC2018/0002472A patent/CO2018002472A2/es unknown
- 2018-08-31 HK HK18111189.8A patent/HK1251574A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR112018003171A2 (pt) | 2018-09-25 |
MX2018002118A (es) | 2018-06-18 |
US9670219B2 (en) | 2017-06-06 |
WO2017030171A1 (fr) | 2017-02-23 |
KR20180037983A (ko) | 2018-04-13 |
ZA201801098B (en) | 2019-04-24 |
CO2018002472A2 (es) | 2018-05-31 |
AR105738A1 (es) | 2017-11-01 |
JPWO2017030171A1 (ja) | 2018-06-07 |
KR102614279B1 (ko) | 2023-12-18 |
EA034794B1 (ru) | 2020-03-23 |
HK1251574A1 (zh) | 2019-02-01 |
IL257450A (en) | 2018-04-30 |
ES2812246T3 (es) | 2021-03-16 |
US20170050973A1 (en) | 2017-02-23 |
EP3345909A1 (fr) | 2018-07-11 |
TW201722962A (zh) | 2017-07-01 |
PT3345909T (pt) | 2020-07-29 |
PH12018500297A1 (en) | 2018-08-13 |
JP6787320B2 (ja) | 2020-11-18 |
CN107922426B (zh) | 2021-03-26 |
EA201890514A1 (ru) | 2018-07-31 |
CA2995554C (fr) | 2023-06-27 |
CN107922426A (zh) | 2018-04-17 |
EP3345909B1 (fr) | 2020-06-17 |
AU2016308406A1 (en) | 2018-03-08 |
EP3345909A4 (fr) | 2019-04-10 |
PL3345909T3 (pl) | 2020-10-19 |
SG11201801193QA (en) | 2018-03-28 |
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