CA2991990C - Biological activities of lactobacillus fermentum qi6 biofilm for improving skin and/or mucosal barrier functions - Google Patents

Biological activities of lactobacillus fermentum qi6 biofilm for improving skin and/or mucosal barrier functions Download PDF

Info

Publication number
CA2991990C
CA2991990C CA2991990A CA2991990A CA2991990C CA 2991990 C CA2991990 C CA 2991990C CA 2991990 A CA2991990 A CA 2991990A CA 2991990 A CA2991990 A CA 2991990A CA 2991990 C CA2991990 C CA 2991990C
Authority
CA
Canada
Prior art keywords
biofilm
skin
composition
activity
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2991990A
Other languages
English (en)
French (fr)
Other versions
CA2991990A1 (en
Inventor
Eva A. Berkes
Nicholas T. MONSUL
Frederick T. BOEHM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quorum Innovations Inc
Original Assignee
Quorum Innovations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quorum Innovations Inc filed Critical Quorum Innovations Inc
Publication of CA2991990A1 publication Critical patent/CA2991990A1/en
Application granted granted Critical
Publication of CA2991990C publication Critical patent/CA2991990C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/20—Bacteria; Substances produced thereby or obtained therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/143—Fermentum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
CA2991990A 2015-07-20 2016-07-19 Biological activities of lactobacillus fermentum qi6 biofilm for improving skin and/or mucosal barrier functions Active CA2991990C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562194630P 2015-07-20 2015-07-20
US62/194,630 2015-07-20
PCT/US2016/042939 WO2017015275A1 (en) 2015-07-20 2016-07-19 Materials and methods for improving immune responses and the skin and/or mucosal barrier function

Publications (2)

Publication Number Publication Date
CA2991990A1 CA2991990A1 (en) 2017-01-26
CA2991990C true CA2991990C (en) 2024-04-16

Family

ID=57835147

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2991990A Active CA2991990C (en) 2015-07-20 2016-07-19 Biological activities of lactobacillus fermentum qi6 biofilm for improving skin and/or mucosal barrier functions

Country Status (17)

Country Link
US (6) US9706778B2 (enExample)
EP (1) EP3324986B1 (enExample)
JP (1) JP6727285B2 (enExample)
KR (1) KR102258415B1 (enExample)
CN (1) CN108135947B (enExample)
AU (1) AU2016297539B9 (enExample)
BR (1) BR112018001187B1 (enExample)
CA (1) CA2991990C (enExample)
DK (1) DK3324986T3 (enExample)
ES (1) ES2904555T3 (enExample)
HU (1) HUE057494T2 (enExample)
IL (1) IL256973B (enExample)
MX (1) MX395076B (enExample)
PL (1) PL3324986T3 (enExample)
PT (1) PT3324986T (enExample)
WO (1) WO2017015275A1 (enExample)
ZA (1) ZA201800209B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0811530B1 (pt) 2007-05-14 2019-01-02 Research Foundation Of State Univ Of New York composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície
WO2017015275A1 (en) * 2015-07-20 2017-01-26 Quorum Innovations, Llc Materials and methods for improving immune responses and the skin and/or mucosal barrier function
EP3579930B1 (en) 2017-02-10 2026-05-20 De Maio Domingos, Mauricio METHOD FOR PROVIDING AN INJECTION TREATMENT PLAN FOR A SUBJECT WITH A TIRED APPEARANCE
US11253454B2 (en) * 2017-03-10 2022-02-22 Johnson & Johnson Consumer Inc. Method for affecting touch
GB201807576D0 (en) 2018-05-09 2018-06-20 Skinbiotherapeutics Plc Compositions and uses thereof
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3685669A1 (en) * 2019-01-23 2020-07-29 Chrisal NV Composition for the decontamination and inoculation of surfaces
EP3741398A1 (en) * 2019-05-20 2020-11-25 Medizinische Hochschule Hannover Method for coating a medical device and coated medical device
IL293368B2 (en) * 2019-11-26 2026-05-01 Quorum Innovations Llc New barrier and protective preparations and their use
US12195502B2 (en) 2020-05-06 2025-01-14 Quorum Innovations, Llc Protein, and therapeutic and cosmetic uses thereof
KR102167387B1 (ko) * 2020-05-14 2020-10-19 코스맥스 주식회사 피부 장벽 강화, 피부 보습 또는 항노화를 위한 조성물
CN116133669A (zh) 2020-06-06 2023-05-16 群体创新有限责任公司 用于抑制包括冠状病毒感染的病毒感染的材料和方法
MX2023003595A (es) * 2020-09-29 2023-04-05 Unilever Ip Holdings B V Una composicion para el cuidado personal que comprende aminoacidos.
US20220142560A1 (en) * 2020-11-06 2022-05-12 Johnson & Johnson Consumer Inc. Microbiome and metobolome clusters to evaluate skin health
KR102573754B1 (ko) * 2021-02-25 2023-09-01 주식회사 차메디텍 신규의 펩타이드 및 이를 포함하는 피부장벽 강화 또는 피부가려움증 억제를 위한 화장료 조성물
KR102389749B1 (ko) * 2021-05-14 2022-04-22 주식회사 세바바이오텍 피부장벽강화 및 항주름 활성을 갖는 피부 유래 락토바실러스 퍼멘텀 아종 세바­１０１ 균주 및 이의 용도
CN113832050B (zh) * 2021-08-13 2022-10-21 广东省科学院微生物研究所(广东省微生物分析检测中心) 一株高效合成烟酰胺、抗光老化的发酵乳杆菌xjc60及其应用
CN114717162A (zh) * 2022-05-17 2022-07-08 廖梅香 发酵乳杆菌及其应用
CN118126875B (zh) * 2024-02-05 2024-11-05 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一株表皮葡萄球菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPS057102A0 (en) * 2002-02-15 2002-03-07 Vri Biomedical Ltd Compositions and methods for treatment of skin disorders
WO2005009342A2 (en) * 2003-07-16 2005-02-03 Pharmacia Corporation Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith
EP1736537A1 (en) * 2005-06-22 2006-12-27 OrganoBalance GmbH Methods and means for protecting the skin against pathogenic microorganisms
JP2007284360A (ja) 2006-04-13 2007-11-01 Mitsukan Group Honsha:Kk 乳酸菌由来のｐｐａｒ依存的遺伝子転写活性化組成物
WO2008064893A1 (en) * 2006-12-01 2008-06-05 Organobalance Gmbh Compositions, kits and uses for protecting the skin against pathogenic microorganisms
EP2227239A2 (en) * 2007-12-06 2010-09-15 Arla Foods Amba Probiotic bacteria and regulation of fat storage
CZ302297B6 (cs) * 2009-11-04 2011-02-09 Bio Agens Research And Development - Bard, S.R.O. Protiplísnová smes s houbovým organismem Pythium oligandrum
JP2013527155A (ja) * 2010-04-16 2013-06-27 ダボス ライフ サイエンス ピーティーイー． リミテッド 皮膚科用途のための少なくとも１つのビタミンｅ成分およびチロシナーゼ阻害剤の相乗的相互作用
WO2012107244A1 (en) * 2011-02-09 2012-08-16 Organobalance Gmbh Peptide for use in the treatment of skin conditions
CN111518866A (zh) 2011-03-01 2020-08-11 群体创新有限责任公司 用于治疗与致病生物膜相关之病症的材料和方法
CN102226157B (zh) * 2011-05-06 2013-01-09 北京龙科方舟生物工程技术有限公司 一株发酵乳杆菌及其应用
CN104010648A (zh) 2011-12-07 2014-08-27 可尔必思株式会社 包含乳酸菌或其处理物的脂质代谢和/或糖代谢改善剂
WO2017015275A1 (en) * 2015-07-20 2017-01-26 Quorum Innovations, Llc Materials and methods for improving immune responses and the skin and/or mucosal barrier function

Also Published As

Publication number Publication date
US20260034184A1 (en) 2026-02-05
HUE057494T2 (hu) 2022-05-28
AU2016297539A1 (en) 2018-02-08
US10004772B2 (en) 2018-06-26
PL3324986T3 (pl) 2022-04-04
EP3324986B1 (en) 2021-11-24
US20170020139A1 (en) 2017-01-26
JP6727285B2 (ja) 2020-07-22
US11564957B2 (en) 2023-01-31
ZA201800209B (en) 2018-12-19
IL256973A (en) 2018-03-29
BR112018001187B1 (pt) 2022-02-15
US12440521B2 (en) 2025-10-14
US20230165915A1 (en) 2023-06-01
IL256973B (en) 2020-06-30
CA2991990A1 (en) 2017-01-26
JP2018527322A (ja) 2018-09-20
AU2016297539B9 (en) 2019-11-28
PT3324986T (pt) 2022-01-26
MX395076B (es) 2025-03-24
US20170296599A1 (en) 2017-10-19
AU2016297539B2 (en) 2019-10-31
KR20180023012A (ko) 2018-03-06
ES2904555T3 (es) 2022-04-05
WO2017015275A1 (en) 2017-01-26
DK3324986T3 (da) 2022-01-31
US20170224748A1 (en) 2017-08-10
CN108135947B (zh) 2022-06-14
US9706778B2 (en) 2017-07-18
EP3324986A1 (en) 2018-05-30
KR102258415B1 (ko) 2021-05-28
BR112018001187A2 (pt) 2018-09-11
HK1253067A1 (zh) 2019-06-06
CN108135947A (zh) 2018-06-08
EP3324986A4 (en) 2019-01-09
US10617726B2 (en) 2020-04-14
US20200215130A1 (en) 2020-07-09
MX2018000870A (es) 2018-05-15

Similar Documents

Publication Publication Date Title
US12440521B2 (en) Materials and methods for improving immune responses and skin and/or mucosal barrier functions
JP6505594B2 (ja) プロバイオティクス細菌
JP7208894B2 (ja) 乳酸菌を含有する化粧料、皮膚保護剤
JP7202422B2 (ja) 皮膚への適用のための組成物及び方法
AU2022275473B2 (en) Ammonia oxidizing bacteria for treatment of acne
CA2897518C (fr) Composition dermatologique topique comportant un peptide antimicrobien cationique couple a un lipide et de l'acide hyaluronique.
WO2017009489A1 (en) Topical compositions
JP2026042872A (ja) 常温保存可能なアンモニア酸化微生物の調製物
HK1253067B (en) Materials and methods for improving immune responses and the skin and/or mucosal barrier function
HK40067061A (en) Ammonia oxidizing bacteria for treatment of acne
GB2602359A (en) Topical wash composition
HK1255251B (en) Ammonia oxidizing bacteria for treatment of acne

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180720

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 8TH ANNIV.) - STANDARD

Year of fee payment: 8

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240715

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250528

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 9TH ANNIV.) - STANDARD

Year of fee payment: 9

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250708

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250708

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 10TH ANNIV.) - STANDARD

Year of fee payment: 10

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260707

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260707