CA2984910C - Solid forms of a compound modulating kinases - Google Patents

Solid forms of a compound modulating kinases Download PDF

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Publication number
CA2984910C
CA2984910C CA2984910A CA2984910A CA2984910C CA 2984910 C CA2984910 C CA 2984910C CA 2984910 A CA2984910 A CA 2984910A CA 2984910 A CA2984910 A CA 2984910A CA 2984910 C CA2984910 C CA 2984910C
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compound
cancer
disease
subject
treating
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CA2984910A1 (en
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Prabha N. Ibrahim
Gary Conrad VISOR
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Daiichi Sankyo Inc
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Visor Gary Conrad
Plexxikon Inc
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Application filed by Visor Gary Conrad, Plexxikon Inc filed Critical Visor Gary Conrad
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2984910A 2015-05-06 2016-05-05 Solid forms of a compound modulating kinases Active CA2984910C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562157902P 2015-05-06 2015-05-06
US62/157,902 2015-05-06
PCT/US2016/031027 WO2016179415A1 (en) 2015-05-06 2016-05-05 Solid forms of a compound modulating kinases

Publications (2)

Publication Number Publication Date
CA2984910A1 CA2984910A1 (en) 2016-11-10
CA2984910C true CA2984910C (en) 2020-09-01

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CA2984910A Active CA2984910C (en) 2015-05-06 2016-05-05 Solid forms of a compound modulating kinases

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US (4) US9802932B2 (https=)
EP (2) EP3292123B1 (https=)
JP (1) JP6946194B2 (https=)
KR (1) KR102630889B1 (https=)
CN (1) CN107548394B (https=)
AU (1) AU2016258027B2 (https=)
BR (1) BR112017023490B1 (https=)
CA (1) CA2984910C (https=)
CO (1) CO2017011534A2 (https=)
CY (1) CY1123796T1 (https=)
DK (1) DK3292123T3 (https=)
ES (1) ES2820827T3 (https=)
HR (1) HRP20201383T1 (https=)
HU (1) HUE050506T2 (https=)
IL (1) IL255313A0 (https=)
LT (1) LT3292123T (https=)
MX (1) MX386963B (https=)
MY (1) MY192352A (https=)
NZ (1) NZ737616A (https=)
PH (1) PH12017501995A1 (https=)
PT (1) PT3292123T (https=)
RS (1) RS60731B1 (https=)
RU (1) RU2730506C2 (https=)
SG (1) SG10201912355TA (https=)
SI (1) SI3292123T1 (https=)
SM (1) SMT202000535T1 (https=)
TW (1) TWI727949B (https=)
WO (1) WO2016179415A1 (https=)
ZA (1) ZA201708007B (https=)

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AU2018307910B2 (en) * 2017-07-25 2024-07-25 Daiichi Sankyo Company, Limited Formulations of a compound modulating kinases
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