CA2979773A1 - Materials and methods for diagnosis and treatment of alzheimer's disease - Google Patents

Materials and methods for diagnosis and treatment of alzheimer's disease Download PDF

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Publication number
CA2979773A1
CA2979773A1 CA2979773A CA2979773A CA2979773A1 CA 2979773 A1 CA2979773 A1 CA 2979773A1 CA 2979773 A CA2979773 A CA 2979773A CA 2979773 A CA2979773 A CA 2979773A CA 2979773 A1 CA2979773 A1 CA 2979773A1
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Prior art keywords
protein
biomarkers
sample
subunit
subject
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Pending
Application number
CA2979773A
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English (en)
French (fr)
Inventor
Ian Hugo Pike
Claire Louise RUSSELL
Malcolm Ward
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Proteome Sciences PLC
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Electrophoretics Ltd
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Publication of CA2979773A1 publication Critical patent/CA2979773A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02002—Phosphoglucomutase (5.4.2.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CA2979773A 2015-03-17 2016-03-17 Materials and methods for diagnosis and treatment of alzheimer's disease Pending CA2979773A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201504432A GB201504432D0 (en) 2015-03-17 2015-03-17 Materials and methods for diagnosis and treatment of alzheimers disease
GB1504432.4 2015-03-17
PCT/EP2016/055883 WO2016146783A1 (en) 2015-03-17 2016-03-17 Materials and methods for diagnosis and treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
CA2979773A1 true CA2979773A1 (en) 2016-09-22

Family

ID=53016214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2979773A Pending CA2979773A1 (en) 2015-03-17 2016-03-17 Materials and methods for diagnosis and treatment of alzheimer's disease

Country Status (6)

Country Link
US (1) US10718785B2 (https=)
EP (1) EP3271728B1 (https=)
JP (2) JP6954839B2 (https=)
CA (1) CA2979773A1 (https=)
GB (1) GB201504432D0 (https=)
WO (1) WO2016146783A1 (https=)

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GB201509134D0 (en) * 2015-05-28 2015-07-15 Electrophoretics Ltd Biomolecules involved in Alzheimer's disease
AU2018308088B2 (en) 2017-07-25 2025-05-29 Truebinding, Inc. Treating cancer by blocking the interaction of TIM-3 and its ligand
KR102034929B1 (ko) * 2017-09-27 2019-10-22 한양대학교 산학협력단 Nckap1 단백질 또는 상기 단백질을 암호화하는 유전자를 포함하는 신경계 퇴행성질환의 예방 또는 치료용 약학적 조성물
WO2019172427A1 (ja) * 2018-03-09 2019-09-12 国立大学法人東京医科歯科大学 Ｍａｒｃｋｓのリン酸化を指標にしたａｄ（アルツハイマー病）、ｆｔｌｄ（前頭側頭葉変性症）、ａｌｓ（筋萎縮性側索硬化症）、ｐｄ（パーキンソン病）およびｄｌｂ（レビー小体型認知症）の検出
KR102063610B1 (ko) * 2018-05-23 2020-01-08 충북대학교 산학협력단 퇴행성 신경질환 진단용 신규한 바이오마커 및 이의 용도
KR102232200B1 (ko) * 2019-03-13 2021-03-25 아주대학교산학협력단 알츠하이머치매 진단 바이오마커
WO2020091222A1 (ko) * 2018-10-30 2020-05-07 아주대학교 산학협력단 알츠하이머성 치매 진단용 바이오마커 단백질 및 이의 용도
KR101992060B1 (ko) * 2018-10-30 2019-06-21 아주대학교산학협력단 알츠하이머치매 진단 체액 바이오마커 후보 단백4종
CN109738653B (zh) * 2019-01-11 2022-04-12 湖南诺琪生物科技有限公司 用于阿尔茨海默症的检测、诊断或风险预测的抗原蛋白组合以及包含其的试剂盒
AU2020214796A1 (en) 2019-01-30 2021-07-29 Truebinding, Inc. Anti-Gal3 antibodies and uses thereof
CN110261272B (zh) * 2019-07-05 2020-08-18 西南交通大学 基于地理探测和pca对pm2.5浓度分布的关键影响因子筛选方法
CN112336859A (zh) * 2019-08-06 2021-02-09 上海绿谷制药有限公司 通过抑制t细胞摄取氨基酸治疗阿尔茨海默病的方法
KR20220104706A (ko) * 2019-10-28 2022-07-26 에전 알츠하이머병의 침묵 단계를 진단하기 위한 바이오마커 및 이의 용도
KR102313455B1 (ko) * 2020-02-27 2021-10-15 이화여자대학교 산학협력단 알츠하이머병 경도인지장애의 진단 또는 알츠하이머병 치매로의 진행 위험성 예측 방법
WO2021242776A2 (en) 2020-05-26 2021-12-02 Truebinding, Inc. Methods of treating inflammatory diseases by blocking galectin-3
CN112695084A (zh) * 2021-02-08 2021-04-23 山东大学第二医院 诊断阿尔茨海默病和阿尔茨海默病进展的生物标志物及应用
GB202102399D0 (en) * 2021-02-19 2021-04-07 Univ Manchester Methods of determining alzheimer's disease
WO2022192019A1 (en) * 2021-03-08 2022-09-15 The Children's Medical Center Corporation Methods for diagnosis and treatment of alzheimer's disease
AU2022348976A1 (en) * 2021-07-23 2024-02-08 Cassava Sciences, Inc. Blood-based diagnostic assays for alzheimer's disease
US20250346956A1 (en) * 2022-06-03 2025-11-13 Seer, Inc. Systems, compositions, and methods relating to neurodegenerative diseases
WO2024073067A2 (en) * 2022-09-30 2024-04-04 Mayo Foundation For Medical Education And Research Assessing and treating tremor

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Also Published As

Publication number Publication date
EP3271728B1 (en) 2024-02-28
JP2018510343A (ja) 2018-04-12
WO2016146783A1 (en) 2016-09-22
JP2021177180A (ja) 2021-11-11
US10718785B2 (en) 2020-07-21
US20180067133A1 (en) 2018-03-08
JP6954839B2 (ja) 2021-10-27
EP3271728A1 (en) 2018-01-24
GB201504432D0 (en) 2015-04-29

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