CA2978965C - 1-((n-(2benzyl-phenyl)-carbamoyl-methyl)-carbamoyl)-naphthalene as anticancer therapeutic agent - Google Patents
1-((n-(2benzyl-phenyl)-carbamoyl-methyl)-carbamoyl)-naphthalene as anticancer therapeutic agent Download PDFInfo
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- CA2978965C CA2978965C CA2978965A CA2978965A CA2978965C CA 2978965 C CA2978965 C CA 2978965C CA 2978965 A CA2978965 A CA 2978965A CA 2978965 A CA2978965 A CA 2978965A CA 2978965 C CA2978965 C CA 2978965C
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
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- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
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- 238000012544 monitoring process Methods 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 239000002105 nanoparticle Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000020520 nucleotide-excision repair Effects 0.000 description 1
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
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- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
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- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
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- 238000006862 quantum yield reaction Methods 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 239000011343 solid material Substances 0.000 description 1
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- 102000009076 src-Family Kinases Human genes 0.000 description 1
- 108010087686 src-Family Kinases Proteins 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
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- 125000003107 substituted aryl group Chemical group 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/684,259 | 2015-04-10 | ||
| US14/684,259 US10420840B2 (en) | 2015-04-10 | 2015-04-10 | Anticancer therapeutic agents |
| PCT/US2016/026619 WO2016164707A1 (en) | 2015-04-10 | 2016-04-08 | Anticancer therapeutic agents |
Publications (2)
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|---|---|
| CA2978965A1 CA2978965A1 (en) | 2016-10-13 |
| CA2978965C true CA2978965C (en) | 2023-11-14 |
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| CA2978965A Active CA2978965C (en) | 2015-04-10 | 2016-04-08 | 1-((n-(2benzyl-phenyl)-carbamoyl-methyl)-carbamoyl)-naphthalene as anticancer therapeutic agent |
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| PL (2) | PL3280261T3 (enExample) |
| PT (1) | PT3878444T (enExample) |
| WO (1) | WO2016164707A1 (enExample) |
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| CN119013247A (zh) * | 2022-03-07 | 2024-11-22 | 希望之城 | Pcna抑制剂及其用途 |
| WO2025054318A1 (en) * | 2023-09-06 | 2025-03-13 | City Of Hope | Pcna inhibitors and uses thereof |
| WO2025184571A1 (en) * | 2024-03-01 | 2025-09-04 | City Of Hope | Pcna inhibitors for the treatment of myc family associated cancers |
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| US5627165A (en) | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US20050037090A1 (en) | 1998-12-23 | 2005-02-17 | Mckearn John P. | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent |
| EP1874823B1 (en) | 2005-04-27 | 2016-01-13 | Indiana University Research and Technology Corporation | Cancer specific pcna isoform binding antibodies and uses thereof |
| CA2612695A1 (en) * | 2005-06-27 | 2007-01-04 | Derek J. Hoelz | Cspcna isoform modifications and uses thereof |
| CN101384618A (zh) * | 2006-02-17 | 2009-03-11 | 印第安纳大学研究及科技有限公司 | 癌中capcna蛋白-蛋白相互作用的肽基抑制 |
| US20090123487A1 (en) | 2007-09-19 | 2009-05-14 | Katia Rothhaar | Precursors and enzymes associated with post translational modification of proteins implicated in isoform generation of PCNA |
| WO2009079451A2 (en) | 2007-12-14 | 2009-06-25 | The Cleveland Clinic Foundation | Compositions and methods of promoting wound healing |
| GB0808282D0 (en) | 2008-05-07 | 2008-06-11 | Medical Res Council | Compounds for use in stabilizing p53 mutants |
| CA2732737C (en) * | 2008-07-24 | 2019-03-05 | Indiana University Research And Technology Corporation | Cancer peptide therapeutics |
| WO2011044374A1 (en) * | 2009-10-07 | 2011-04-14 | Indiana University Research And Technology Corporation | Capcna peptide therapeutics for cancer |
| US20130345231A1 (en) * | 2011-03-23 | 2013-12-26 | Indiana University Research And Technology Corporation | Anticancer therapeutic agents |
| US10550070B2 (en) * | 2015-09-17 | 2020-02-04 | City Of Hope | PCNA inhibitors |
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2015
- 2015-04-10 US US14/684,259 patent/US10420840B2/en active Active
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2016
- 2016-04-08 WO PCT/US2016/026619 patent/WO2016164707A1/en not_active Ceased
- 2016-04-08 CN CN201680018509.6A patent/CN107404876B/zh active Active
- 2016-04-08 EP EP16777344.9A patent/EP3280261B1/en active Active
- 2016-04-08 PT PT202162491T patent/PT3878444T/pt unknown
- 2016-04-08 PL PL16777344T patent/PL3280261T3/pl unknown
- 2016-04-08 JP JP2018504078A patent/JP6748704B2/ja active Active
- 2016-04-08 FI FIEP20216249.1T patent/FI3878444T3/fi active
- 2016-04-08 PL PL20216249.1T patent/PL3878444T3/pl unknown
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- 2016-04-08 ES ES20216249T patent/ES2991018T3/es active Active
- 2016-04-08 EP EP20216249.1A patent/EP3878444B1/en active Active
- 2016-04-08 CA CA2978965A patent/CA2978965C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016245886A1 (en) | 2017-10-12 |
| EP3280261A1 (en) | 2018-02-14 |
| FI3878444T3 (fi) | 2024-11-19 |
| JP2018510917A (ja) | 2018-04-19 |
| EP3280261A4 (en) | 2018-12-12 |
| AU2016245886B2 (en) | 2020-04-30 |
| CN107404876A (zh) | 2017-11-28 |
| US20160296482A1 (en) | 2016-10-13 |
| PT3878444T (pt) | 2024-11-08 |
| US10420840B2 (en) | 2019-09-24 |
| PL3878444T3 (pl) | 2025-01-07 |
| CA2978965A1 (en) | 2016-10-13 |
| EP3878444A1 (en) | 2021-09-15 |
| BR112017019983A2 (pt) | 2018-06-19 |
| PL3280261T3 (pl) | 2021-09-06 |
| EP3878444B1 (en) | 2024-10-09 |
| WO2016164707A1 (en) | 2016-10-13 |
| EP3280261B1 (en) | 2020-12-23 |
| BR122023024844A2 (pt) | 2024-01-23 |
| ES2991018T3 (es) | 2024-12-02 |
| CN107404876B (zh) | 2023-04-14 |
| JP6748704B2 (ja) | 2020-09-02 |
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