CA2978374A1 - Modified von willebrand factor having improved half-life - Google Patents

Modified von willebrand factor having improved half-life Download PDF

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Publication number
CA2978374A1
CA2978374A1 CA2978374A CA2978374A CA2978374A1 CA 2978374 A1 CA2978374 A1 CA 2978374A1 CA 2978374 A CA2978374 A CA 2978374A CA 2978374 A CA2978374 A CA 2978374A CA 2978374 A1 CA2978374 A1 CA 2978374A1
Authority
CA
Canada
Prior art keywords
vwf
molecule
amino acid
factor viii
fviii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2978374A
Other languages
English (en)
French (fr)
Inventor
Michael Moses
Stefan Schulte
Gerhard Dickneite
Uwe Kalina
Sabine Pestel
Thomas Weimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring Lengnau AG
Original Assignee
CSL Behring Recombinant Facility AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CSL Behring Recombinant Facility AG filed Critical CSL Behring Recombinant Facility AG
Publication of CA2978374A1 publication Critical patent/CA2978374A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2978374A 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life Abandoned CA2978374A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15158065.1 2015-03-06
EP15158065 2015-03-06
PCT/EP2016/054647 WO2016142288A1 (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

Publications (1)

Publication Number Publication Date
CA2978374A1 true CA2978374A1 (en) 2016-09-15

Family

ID=52629450

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2978374A Abandoned CA2978374A1 (en) 2015-03-06 2016-03-04 Modified von willebrand factor having improved half-life

Country Status (12)

Country Link
US (1) US11155601B2 (https=)
EP (1) EP3265483B1 (https=)
JP (1) JP2018510212A (https=)
KR (1) KR20170125941A (https=)
CN (1) CN107406493B (https=)
AU (1) AU2016231327B2 (https=)
BR (1) BR112017018468A2 (https=)
CA (1) CA2978374A1 (https=)
DK (1) DK3265483T3 (https=)
ES (1) ES2772933T3 (https=)
SG (1) SG11201706659WA (https=)
WO (1) WO2016142288A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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EA202192140A1 (ru) * 2019-02-01 2021-12-15 Такеда Фармасьютикал Компани Лимитед СПОСОБЫ ПРОФИЛАКТИЧЕСКОГО ЛЕЧЕНИЯ РЕКОМБИНАНТНЫМ ФВ (рФВ)
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WO2021001522A1 (en) * 2019-07-04 2021-01-07 CSL Behring Lengnau AG A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii
US20220348637A1 (en) * 2019-11-11 2022-11-03 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii

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Also Published As

Publication number Publication date
JP2018510212A (ja) 2018-04-12
EP3265483A1 (en) 2018-01-10
AU2016231327B2 (en) 2018-08-09
KR20170125941A (ko) 2017-11-15
BR112017018468A2 (pt) 2018-04-17
EP3265483B1 (en) 2019-12-11
US11155601B2 (en) 2021-10-26
ES2772933T3 (es) 2020-07-08
CN107406493B (zh) 2021-08-13
DK3265483T3 (da) 2020-03-02
SG11201706659WA (en) 2017-09-28
HK1244292A1 (en) 2018-08-03
AU2016231327A1 (en) 2017-10-26
WO2016142288A1 (en) 2016-09-15
CN107406493A (zh) 2017-11-28
US20180051067A1 (en) 2018-02-22

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20220525