CA2970469A1 - Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer - Google Patents

Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer Download PDF

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Publication number
CA2970469A1
CA2970469A1 CA2970469A CA2970469A CA2970469A1 CA 2970469 A1 CA2970469 A1 CA 2970469A1 CA 2970469 A CA2970469 A CA 2970469A CA 2970469 A CA2970469 A CA 2970469A CA 2970469 A1 CA2970469 A1 CA 2970469A1
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Prior art keywords
basal
classifier score
breast cancer
luminal
subject
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Pending
Application number
CA2970469A
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English (en)
French (fr)
Inventor
Amy Christian Peterson
Hirdesh Uppal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivation Prostate Therapeutics LLC
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Medivation Prostate Therapeutics LLC
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Application filed by Medivation Prostate Therapeutics LLC filed Critical Medivation Prostate Therapeutics LLC
Publication of CA2970469A1 publication Critical patent/CA2970469A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2970469A 2014-12-12 2015-12-08 Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer Pending CA2970469A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462091195P 2014-12-12 2014-12-12
US62/091,195 2014-12-12
US201562142504P 2015-04-03 2015-04-03
US62/142,504 2015-04-03
US201562167110P 2015-05-27 2015-05-27
US62/167,110 2015-05-27
PCT/US2015/064500 WO2016094408A1 (en) 2014-12-12 2015-12-08 Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer

Publications (1)

Publication Number Publication Date
CA2970469A1 true CA2970469A1 (en) 2016-06-16

Family

ID=55273509

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2970469A Pending CA2970469A1 (en) 2014-12-12 2015-12-08 Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer

Country Status (15)

Country Link
US (3) US10196693B2 (enExample)
EP (2) EP3604556A1 (enExample)
JP (1) JP6735277B2 (enExample)
KR (1) KR20170095306A (enExample)
CN (1) CN107109488A (enExample)
AU (1) AU2015360767A1 (enExample)
BR (1) BR112017012142A2 (enExample)
CA (1) CA2970469A1 (enExample)
ES (1) ES2748005T3 (enExample)
IL (1) IL252587A0 (enExample)
MX (1) MX2017007707A (enExample)
RU (1) RU2017120330A (enExample)
SG (1) SG11201704425TA (enExample)
WO (1) WO2016094408A1 (enExample)
ZA (1) ZA201703904B (enExample)

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BR112017012142A2 (pt) 2014-12-12 2018-01-02 Medivation Prostate Therapeutics Inc método para predição da resposta a agentes terapêuticos para o câncer de mama e método de tratamento de câncer de mama
AU2016274988A1 (en) 2015-06-12 2017-12-21 Indiana University Research & Technology Corporation Predicting suicidality using a combined genomic and clinical risk assessment
KR101966493B1 (ko) * 2016-06-27 2019-04-05 국립암센터 삼중음성유방암 예후 예측용 바이오마커
KR101896558B1 (ko) * 2016-11-21 2018-09-07 주식회사 젠큐릭스 유방암 환자의 예후 예측 방법
WO2018198927A1 (ja) * 2017-04-26 2018-11-01 日本電信電話株式会社 Ｎ×ｎ光スイッチ
CA3105451A1 (en) 2017-05-12 2018-11-15 Indiana University Research And Technology Corporation Precision medicine for treating and preventing suicidality
RU2648523C1 (ru) * 2017-05-22 2018-03-26 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") Способ прогнозирования исхода заболевания у больных люминальным в и трижды негативным раком молочной железы у пациенток, не получавших в неоадъювантном режиме химио- или гормонотерапию
AU2019268481B2 (en) * 2018-05-14 2025-04-03 Hinova Pharmaceuticals Inc. HC-1119 formulation, preparation method and use thereof
WO2020001473A1 (zh) * 2018-06-28 2020-01-02 复旦大学 小核仁核糖核酸snord33作为生物标记物用于制备检测试剂盒中的用途
CN109735625A (zh) * 2019-03-18 2019-05-10 马榕 乳头溢液在检测肿瘤相关基因中的应用
CN114334000B (zh) * 2021-12-28 2025-07-25 上海中医药大学 基于转录组图谱的组合药物生成方法、系统及存储介质
US20260043086A1 (en) * 2022-08-06 2026-02-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Predictive biomarker in avastin in colon cancer

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Also Published As

Publication number Publication date
US10196693B2 (en) 2019-02-05
US20160168646A1 (en) 2016-06-16
US11952634B2 (en) 2024-04-09
BR112017012142A2 (pt) 2018-01-02
CN107109488A (zh) 2017-08-29
US20190169697A1 (en) 2019-06-06
SG11201704425TA (en) 2017-06-29
KR20170095306A (ko) 2017-08-22
EP3604556A1 (en) 2020-02-05
WO2016094408A1 (en) 2016-06-16
IL252587A0 (en) 2017-07-31
ZA201703904B (en) 2019-12-18
EP3230471B1 (en) 2019-08-28
US11186876B2 (en) 2021-11-30
US20220056541A1 (en) 2022-02-24
JP2018504892A (ja) 2018-02-22
AU2015360767A1 (en) 2017-06-08
RU2017120330A (ru) 2019-01-14
EP3230471A1 (en) 2017-10-18
MX2017007707A (es) 2018-03-06
RU2017120330A3 (enExample) 2019-07-24
JP6735277B2 (ja) 2020-08-05
ES2748005T3 (es) 2020-03-12

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