CA2968242C - 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139 - Google Patents

4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139 Download PDF

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Publication number
CA2968242C
CA2968242C CA2968242A CA2968242A CA2968242C CA 2968242 C CA2968242 C CA 2968242C CA 2968242 A CA2968242 A CA 2968242A CA 2968242 A CA2968242 A CA 2968242A CA 2968242 C CA2968242 C CA 2968242C
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Prior art keywords
oxobenzo
triazin
ethyl
acetamide
methoxy
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CA2968242A
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English (en)
French (fr)
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CA2968242A1 (en
Inventor
Stephen Hitchcock
Betty Lam
Holger Monenschein
Holly REICHARD
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2968242A 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139 Active CA2968242C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462082539P 2014-11-20 2014-11-20
US62/082,539 2014-11-20
US201562184729P 2015-06-25 2015-06-25
US62/184,729 2015-06-25
PCT/US2015/061607 WO2016081736A1 (en) 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139

Publications (2)

Publication Number Publication Date
CA2968242A1 CA2968242A1 (en) 2016-05-26
CA2968242C true CA2968242C (en) 2022-11-08

Family

ID=55022667

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968242A Active CA2968242C (en) 2014-11-20 2015-11-19 4-oxo-3,4-dihydro-1,2,3-benzotriazines as modulators of gpr139

Country Status (40)

Country Link
US (5) US9556130B2 (en:Method)
EP (2) EP3536324B1 (en:Method)
JP (2) JP6637501B2 (en:Method)
KR (1) KR102582021B1 (en:Method)
CN (2) CN107108531B (en:Method)
AU (1) AU2015349866B2 (en:Method)
CA (1) CA2968242C (en:Method)
CL (1) CL2017001292A1 (en:Method)
CO (1) CO2017005959A2 (en:Method)
CR (1) CR20170275A (en:Method)
CY (2) CY1122613T1 (en:Method)
DK (2) DK3536324T3 (en:Method)
DO (1) DOP2017000120A (en:Method)
EA (1) EA033728B1 (en:Method)
EC (1) ECSP17038999A (en:Method)
ES (2) ES2897545T3 (en:Method)
GE (2) GEP20196961B (en:Method)
HR (2) HRP20191003T1 (en:Method)
HU (2) HUE044145T2 (en:Method)
IL (1) IL252311B (en:Method)
JO (1) JO3719B1 (en:Method)
LT (2) LT3536324T (en:Method)
MA (1) MA40993B1 (en:Method)
MD (1) MD3221298T2 (en:Method)
MX (1) MX378158B (en:Method)
MY (1) MY187423A (en:Method)
NZ (1) NZ732208A (en:Method)
PE (1) PE20170899A1 (en:Method)
PH (1) PH12017500920B1 (en:Method)
PL (2) PL3221298T3 (en:Method)
PT (2) PT3221298T (en:Method)
RS (2) RS59078B1 (en:Method)
SG (1) SG11201704002UA (en:Method)
SI (2) SI3536324T1 (en:Method)
SM (2) SMT201900355T1 (en:Method)
TN (1) TN2017000196A1 (en:Method)
TW (1) TWI684590B (en:Method)
UA (1) UA120375C2 (en:Method)
UY (1) UY36406A (en:Method)
WO (1) WO2016081736A1 (en:Method)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3719B1 (ar) 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
WO2020081538A1 (en) 2018-10-16 2020-04-23 The Scripps Research Institute Methods related to opioid therapeutics
WO2020097609A1 (en) 2018-11-09 2020-05-14 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
PL4031552T3 (pl) 2019-09-16 2025-03-17 Takeda Pharmaceutical Company Limited Pochodne azolowo-skondensowanych pirydazyn-3(2h)-onów
WO2021127459A1 (en) * 2019-12-20 2021-06-24 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
JP7697974B2 (ja) * 2020-05-08 2025-06-24 武田薬品工業株式会社 Ｇｐｒ１３９アゴニストの置換ベンゾトリアジノン代謝物
TW202227087A (zh) * 2020-09-21 2022-07-16 日商武田藥品工業股份有限公司 精神分裂症之治療
US11760788B2 (en) 2021-03-02 2023-09-19 Pathways Neuro Pharma, Inc. Neuroreceptor compositions and methods of use
WO2023165262A1 (zh) * 2022-03-01 2023-09-07 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
US20250163065A1 (en) * 2022-03-01 2025-05-22 Shanghaitech University Pyrrolotriazinone compound, pharmaceutical composition comprising same, preparation method therefor, and use thereof
CN117986183A (zh) * 2022-10-28 2024-05-07 浙江友宁生物医药科技有限公司 一种gpr139受体激动剂、其制备方法及其应用
WO2024102802A1 (en) * 2022-11-11 2024-05-16 Takeda Pharmaceutical Company Limited Zelatriazin for the treatment of depression
WO2025119351A1 (zh) * 2023-12-08 2025-06-12 深圳湾实验室 Gpr139激动剂
WO2025162441A1 (zh) * 2024-02-02 2025-08-07 上海科技大学 稠杂环类化合物与其制备方法、药物组合物及应用
CN121159462A (zh) * 2025-11-19 2025-12-19 杭州市第七人民医院(杭州市心理危机研究与干预中心) 喹唑啉酮类化合物及其在制备神经系统疾病药物中的应用

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EP0799617A3 (en) 1986-02-24 1997-11-12 Mitsui Petrochemical Industries, Ltd. Therapeutic agent for neurological diseases
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FR2875805B1 (fr) 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
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HUE044145T2 (hu) 2019-09-30
TWI684590B (zh) 2020-02-11
EP3221298A1 (en) 2017-09-27
TW201625566A (zh) 2016-07-16
TN2017000196A1 (en) 2018-10-19
PH12017500920A1 (en) 2017-11-20
IL252311B (en) 2020-07-30
HUE057451T2 (hu) 2022-05-28
MD3221298T2 (ro) 2019-10-31
PT3221298T (pt) 2019-06-28
US10159677B2 (en) 2018-12-25
PE20170899A1 (es) 2017-07-12
HRP20212009T1 (hr) 2022-04-01
EA201791096A1 (ru) 2017-11-30
CN107108531B (zh) 2020-10-20
US20160145218A1 (en) 2016-05-26
JP6918088B2 (ja) 2021-08-11
GEAP201814515A (en) 2018-12-10
ES2897545T3 (es) 2022-03-01
US10561662B2 (en) 2020-02-18
LT3536324T (lt) 2021-12-10
KR20170084324A (ko) 2017-07-19
DK3221298T3 (da) 2019-06-24
CO2017005959A2 (es) 2017-10-20
CY1122613T1 (el) 2021-05-05
CN107108531A (zh) 2017-08-29
MA40993A (fr) 2017-09-27
SMT202200142T1 (it) 2022-05-12
IL252311A0 (en) 2017-07-31
US20200129518A1 (en) 2020-04-30
WO2016081736A1 (en) 2016-05-26
DOP2017000120A (es) 2017-06-15
KR102582021B1 (ko) 2023-09-22
MY187423A (en) 2021-09-22
US9770450B2 (en) 2017-09-26
RS59078B1 (sr) 2019-09-30
HRP20191003T1 (hr) 2019-08-23
US20190070187A1 (en) 2019-03-07
US20170348319A1 (en) 2017-12-07
LT3221298T (lt) 2019-08-12
UY36406A (es) 2016-06-30
CR20170275A (es) 2017-10-30
ES2734735T3 (es) 2019-12-11
NZ732208A (en) 2023-02-24
AU2015349866B2 (en) 2020-12-03
CY1124929T1 (el) 2023-01-05
CA2968242A1 (en) 2016-05-26
EP3221298B1 (en) 2019-04-03
PH12017500920B1 (en) 2017-11-20
ECSP17038999A (es) 2017-10-31
CL2017001292A1 (es) 2018-02-16
UA120375C2 (uk) 2019-11-25
EP3536324A1 (en) 2019-09-11
BR112017010311A2 (pt) 2017-12-26
DK3536324T3 (da) 2021-10-25
CN112062730A (zh) 2020-12-11
US20170095480A1 (en) 2017-04-06
EA033728B1 (ru) 2019-11-20
JP2020063285A (ja) 2020-04-23
US9556130B2 (en) 2017-01-31
SG11201704002UA (en) 2017-06-29
GEP20196961B (en) 2019-03-25
PL3221298T3 (pl) 2019-10-31
MX2017006448A (es) 2017-09-12
EP3536324B1 (en) 2021-10-06
US11173161B2 (en) 2021-11-16
JP2017535559A (ja) 2017-11-30
PT3536324T (pt) 2021-11-10
PL3536324T3 (pl) 2022-02-07
MA40993B1 (fr) 2019-07-31
CN112062730B (zh) 2023-09-29
MX378158B (es) 2025-03-10
JP6637501B2 (ja) 2020-01-29
AU2015349866A1 (en) 2017-06-15
JO3719B1 (ar) 2021-01-31
RS62563B1 (sr) 2021-12-31
SMT201900355T1 (it) 2019-07-11
SI3221298T1 (sl) 2019-10-30
SI3536324T1 (sl) 2021-12-31

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