CA2922802C - Compositions and methods for the treatment of presbyopia - Google Patents

Compositions and methods for the treatment of presbyopia Download PDF

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Publication number
CA2922802C
CA2922802C CA2922802A CA2922802A CA2922802C CA 2922802 C CA2922802 C CA 2922802C CA 2922802 A CA2922802 A CA 2922802A CA 2922802 A CA2922802 A CA 2922802A CA 2922802 C CA2922802 C CA 2922802C
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CA
Canada
Prior art keywords
concentration
composition
aceclidine
present
vision
Prior art date
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Active
Application number
CA2922802A
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English (en)
French (fr)
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CA2922802A1 (en
Inventor
Gerald Horn
Lee NORDAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lenz Therapeutics Inc
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Presbyopia Therapies Inc
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Application filed by Presbyopia Therapies Inc filed Critical Presbyopia Therapies Inc
Publication of CA2922802A1 publication Critical patent/CA2922802A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2922802A 2013-08-28 2014-08-22 Compositions and methods for the treatment of presbyopia Active CA2922802C (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361871215P 2013-08-28 2013-08-28
US61/871,215 2013-08-28
US201361882998P 2013-09-26 2013-09-26
US61/882,998 2013-09-26
US201361904510P 2013-11-15 2013-11-15
US61/904,510 2013-11-15
US201361917620P 2013-12-18 2013-12-18
US61/917,620 2013-12-18
US201461938438P 2014-02-11 2014-02-11
US61/938,438 2014-02-11
PCT/US2014/052256 WO2015031186A1 (en) 2013-08-28 2014-08-22 Compositions and methods for the treatment of presbyopia

Publications (2)

Publication Number Publication Date
CA2922802A1 CA2922802A1 (en) 2015-03-05
CA2922802C true CA2922802C (en) 2021-04-27

Family

ID=52584080

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2922802A Active CA2922802C (en) 2013-08-28 2014-08-22 Compositions and methods for the treatment of presbyopia

Country Status (22)

Country Link
US (1) US9089562B2 (https=)
EP (3) EP3542798B1 (https=)
JP (6) JP6426743B2 (https=)
KR (4) KR20160045147A (https=)
CN (1) CN105792815B (https=)
AU (2) AU2014311558B2 (https=)
CA (1) CA2922802C (https=)
DK (1) DK3542798T3 (https=)
ES (1) ES3028364T3 (https=)
FI (1) FI3542798T3 (https=)
HK (1) HK1225654A1 (https=)
HR (1) HRP20250507T1 (https=)
HU (1) HUE071646T2 (https=)
LT (1) LT3542798T (https=)
MX (2) MX393360B (https=)
PL (1) PL3542798T3 (https=)
PT (1) PT3542798T (https=)
RS (1) RS66821B1 (https=)
SG (1) SG11201601412XA (https=)
SI (1) SI3542798T1 (https=)
SM (1) SMT202500311T1 (https=)
WO (1) WO2015031186A1 (https=)

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Publication number Publication date
CA2922802A1 (en) 2015-03-05
ES3028364T3 (en) 2025-06-19
EP3542798B1 (en) 2025-03-19
PT3542798T (pt) 2025-05-20
AU2019200623B2 (en) 2019-10-03
LT3542798T (lt) 2025-06-10
KR20220129097A (ko) 2022-09-22
AU2019200623A1 (en) 2019-02-21
SG11201601412XA (en) 2016-03-30
JP2021183634A (ja) 2021-12-02
WO2015031186A1 (en) 2015-03-05
EP3038610A1 (en) 2016-07-06
AU2014311558A1 (en) 2016-03-17
JP7358221B2 (ja) 2023-10-10
KR20160045147A (ko) 2016-04-26
JP2025131705A (ja) 2025-09-09
EP4563162A3 (en) 2025-08-20
JP7329019B2 (ja) 2023-08-17
US20150065511A1 (en) 2015-03-05
MX393360B (es) 2025-03-24
MX2020002922A (es) 2020-07-22
AU2014311558B2 (en) 2019-01-24
RS66821B1 (sr) 2025-06-30
HUE071646T2 (hu) 2025-09-28
MX2016002623A (es) 2016-09-23
JP2016529297A (ja) 2016-09-23
KR20260008183A (ko) 2026-01-15
HRP20250507T1 (hr) 2025-06-20
KR20230157530A (ko) 2023-11-16
JP6426743B2 (ja) 2018-11-21
JP2019031538A (ja) 2019-02-28
PL3542798T3 (pl) 2025-09-08
SMT202500311T1 (it) 2025-09-12
HK1225654A1 (zh) 2017-09-15
US9089562B2 (en) 2015-07-28
KR102905081B1 (ko) 2025-12-26
CN105792815A (zh) 2016-07-20
EP3542798A1 (en) 2019-09-25
EP3038610A4 (en) 2017-03-22
DK3542798T3 (da) 2025-05-19
JP2023103400A (ja) 2023-07-26
KR102600484B1 (ko) 2023-11-09
JP2020055851A (ja) 2020-04-09
CN105792815B (zh) 2018-08-28
SI3542798T1 (sl) 2025-07-31
EP4563162A2 (en) 2025-06-04
FI3542798T3 (fi) 2025-05-21

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