CA2920996A1 - Composes heteroaryles et leurs utilisations - Google Patents
Composes heteroaryles et leurs utilisations Download PDFInfo
- Publication number
- CA2920996A1 CA2920996A1 CA2920996A CA2920996A CA2920996A1 CA 2920996 A1 CA2920996 A1 CA 2920996A1 CA 2920996 A CA2920996 A CA 2920996A CA 2920996 A CA2920996 A CA 2920996A CA 2920996 A1 CA2920996 A1 CA 2920996A1
- Authority
- CA
- Canada
- Prior art keywords
- ring
- halogen
- compound according
- oxo
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- VECRDXZMKNMOGD-JJPRUIFNSA-N C#Cc1cc(Nc2cc(Nc3cc(C#C/C=C/S(Nc4cc(Nc5ncnc(Oc6cc(C(F)(F)F)ccc6)c5)ccc4)(=O)=O)ccc3)ncn2)ccc1 Chemical compound C#Cc1cc(Nc2cc(Nc3cc(C#C/C=C/S(Nc4cc(Nc5ncnc(Oc6cc(C(F)(F)F)ccc6)c5)ccc4)(=O)=O)ccc3)ncn2)ccc1 VECRDXZMKNMOGD-JJPRUIFNSA-N 0.000 description 1
- TUOBRNIHTROIGD-UHFFFAOYSA-N C#Cc1cc(Nc2ncnc(Nc3cccc(Br)c3)c2)ccc1 Chemical compound C#Cc1cc(Nc2ncnc(Nc3cccc(Br)c3)c2)ccc1 TUOBRNIHTROIGD-UHFFFAOYSA-N 0.000 description 1
- 0 C=CC(Nc1cc(Nc2ncnc(Nc(cc3*4CC4)ccc3OCc3ncccc3)c2)ccc1)=O Chemical compound C=CC(Nc1cc(Nc2ncnc(Nc(cc3*4CC4)ccc3OCc3ncccc3)c2)ccc1)=O 0.000 description 1
- YOYNKEKMOGXNMS-UHFFFAOYSA-N C=CC(Nc1cccc(Nc2cc(N3c4ccccc4CC3)ncn2)c1)=O Chemical compound C=CC(Nc1cccc(Nc2cc(N3c4ccccc4CC3)ncn2)c1)=O YOYNKEKMOGXNMS-UHFFFAOYSA-N 0.000 description 1
- IOSLVUVNCXSTTN-UHFFFAOYSA-N C=CC(Nc1cccc(Nc2ncnc(Nc(cc3)ccc3Oc3ccccc3)c2)c1)=O Chemical compound C=CC(Nc1cccc(Nc2ncnc(Nc(cc3)ccc3Oc3ccccc3)c2)c1)=O IOSLVUVNCXSTTN-UHFFFAOYSA-N 0.000 description 1
- XMPFPOZGSDPNEN-WOJGMQOQSA-N CC(C)N(CC#Cc1cccc(Nc2cc(Nc(cc3)cc([ClH]N(C)C/C=C/C(Nc4cccc(Nc5ncnc(Nc(cc6Cl)ccc6OCc6ncccc6)c5)c4)=O)c3F)ncn2)c1)C(C)C Chemical compound CC(C)N(CC#Cc1cccc(Nc2cc(Nc(cc3)cc([ClH]N(C)C/C=C/C(Nc4cccc(Nc5ncnc(Nc(cc6Cl)ccc6OCc6ncccc6)c5)c4)=O)c3F)ncn2)c1)C(C)C XMPFPOZGSDPNEN-WOJGMQOQSA-N 0.000 description 1
- CCQAUJNCHNEAIC-BJMVGYQFSA-N CN(C)C/C=C/C(Nc1cc(Nc2cc(Nc3cc(N)ccc3)ncn2)ccc1)=O Chemical compound CN(C)C/C=C/C(Nc1cc(Nc2cc(Nc3cc(N)ccc3)ncn2)ccc1)=O CCQAUJNCHNEAIC-BJMVGYQFSA-N 0.000 description 1
- WZUQKIONKGEIBI-QPJJXVBHSA-N CN(C)C/C=C/C(Nc1cccc(Nc2ncnc(Nc(cc3)cc(N)c3F)c2)c1)=O Chemical compound CN(C)C/C=C/C(Nc1cccc(Nc2ncnc(Nc(cc3)cc(N)c3F)c2)c1)=O WZUQKIONKGEIBI-QPJJXVBHSA-N 0.000 description 1
- ROKBHLOYIAOJCM-UHFFFAOYSA-N CN(c1ccccc1)c1cc(Nc2cc(NC(C=C)=O)ccc2)ncn1 Chemical compound CN(c1ccccc1)c1cc(Nc2cc(NC(C=C)=O)ccc2)ncn1 ROKBHLOYIAOJCM-UHFFFAOYSA-N 0.000 description 1
- LHMRQEXPEHNEIM-GORDUTHDSA-N O=C(/C=C/CN1CCOCC1)Nc1cccc(Nc2ncnc(Nc(cc3)cc(Cl)c3F)c2)c1 Chemical compound O=C(/C=C/CN1CCOCC1)Nc1cccc(Nc2ncnc(Nc(cc3)cc(Cl)c3F)c2)c1 LHMRQEXPEHNEIM-GORDUTHDSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Obesity (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98143207P | 2007-10-19 | 2007-10-19 | |
US60/981,432 | 2007-10-19 | ||
US5200208P | 2008-05-09 | 2008-05-09 | |
US61/052,002 | 2008-05-09 | ||
CA2702674A CA2702674C (fr) | 2007-10-19 | 2008-10-17 | Composes heteroaryles et leurs utilisations |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2702674A Division CA2702674C (fr) | 2007-10-19 | 2008-10-17 | Composes heteroaryles et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2920996A1 true CA2920996A1 (fr) | 2009-04-23 |
Family
ID=40567710
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2702674A Expired - Fee Related CA2702674C (fr) | 2007-10-19 | 2008-10-17 | Composes heteroaryles et leurs utilisations |
CA2920996A Abandoned CA2920996A1 (fr) | 2007-10-19 | 2008-10-17 | Composes heteroaryles et leurs utilisations |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2702674A Expired - Fee Related CA2702674C (fr) | 2007-10-19 | 2008-10-17 | Composes heteroaryles et leurs utilisations |
Country Status (8)
Country | Link |
---|---|
US (5) | US7982036B2 (fr) |
EP (1) | EP2214486A4 (fr) |
JP (2) | JP5600063B2 (fr) |
CN (2) | CN105367503A (fr) |
AU (3) | AU2008314632B2 (fr) |
CA (2) | CA2702674C (fr) |
TW (2) | TWI475996B (fr) |
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-
2008
- 2008-10-17 US US12/253,424 patent/US7982036B2/en not_active Expired - Fee Related
- 2008-10-17 CA CA2702674A patent/CA2702674C/fr not_active Expired - Fee Related
- 2008-10-17 CN CN201510792304.0A patent/CN105367503A/zh active Pending
- 2008-10-17 CA CA2920996A patent/CA2920996A1/fr not_active Abandoned
- 2008-10-17 CN CN200880121536.1A patent/CN101902911B/zh not_active Expired - Fee Related
- 2008-10-17 JP JP2010529960A patent/JP5600063B2/ja not_active Expired - Fee Related
- 2008-10-17 TW TW097139912A patent/TWI475996B/zh not_active IP Right Cessation
- 2008-10-17 WO PCT/US2008/011911 patent/WO2009051822A1/fr active Application Filing
- 2008-10-17 AU AU2008314632A patent/AU2008314632B2/en not_active Ceased
- 2008-10-17 EP EP08839939A patent/EP2214486A4/fr not_active Withdrawn
- 2008-10-17 TW TW103145233A patent/TWI552752B/zh not_active IP Right Cessation
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2011
- 2011-02-01 US US13/018,624 patent/US8445498B2/en not_active Expired - Fee Related
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2013
- 2013-05-02 US US13/875,755 patent/US9040541B2/en not_active Expired - Fee Related
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2014
- 2014-05-30 JP JP2014112633A patent/JP2014156489A/ja active Pending
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2015
- 2015-04-22 US US14/693,489 patent/US9393246B2/en not_active Expired - Fee Related
- 2015-05-18 AU AU2015202675A patent/AU2015202675B2/en not_active Expired - Fee Related
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2016
- 2016-07-12 US US15/208,368 patent/US20160311780A1/en not_active Abandoned
- 2016-11-10 AU AU2016256754A patent/AU2016256754A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113121575A (zh) * | 2014-08-25 | 2021-07-16 | 四川海思科制药有限公司 | 一种(取代的苯基)(取代的嘧啶)胺基衍生物及其制备方法和药物用途 |
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CA2702674A1 (fr) | 2009-04-23 |
TWI552752B (zh) | 2016-10-11 |
US20110230494A1 (en) | 2011-09-22 |
US20160311780A1 (en) | 2016-10-27 |
TWI475996B (zh) | 2015-03-11 |
JP5600063B2 (ja) | 2014-10-01 |
US20150328223A1 (en) | 2015-11-19 |
JP2011500685A (ja) | 2011-01-06 |
CN105367503A (zh) | 2016-03-02 |
US20130217688A1 (en) | 2013-08-22 |
CN101902911A (zh) | 2010-12-01 |
US9393246B2 (en) | 2016-07-19 |
US8445498B2 (en) | 2013-05-21 |
CN101902911B (zh) | 2015-12-16 |
AU2015202675B2 (en) | 2016-12-01 |
AU2008314632B2 (en) | 2015-05-28 |
US9040541B2 (en) | 2015-05-26 |
US20090137588A1 (en) | 2009-05-28 |
TW201529072A (zh) | 2015-08-01 |
AU2016256754A1 (en) | 2016-12-01 |
EP2214486A1 (fr) | 2010-08-11 |
US7982036B2 (en) | 2011-07-19 |
EP2214486A4 (fr) | 2011-03-09 |
TW200924776A (en) | 2009-06-16 |
WO2009051822A1 (fr) | 2009-04-23 |
AU2008314632A1 (en) | 2009-04-23 |
JP2014156489A (ja) | 2014-08-28 |
CA2702674C (fr) | 2016-05-03 |
AU2015202675A1 (en) | 2015-06-11 |
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