CA2914805C - Ocular devices and methods of making and using thereof - Google Patents

Ocular devices and methods of making and using thereof Download PDF

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Publication number
CA2914805C
CA2914805C CA2914805A CA2914805A CA2914805C CA 2914805 C CA2914805 C CA 2914805C CA 2914805 A CA2914805 A CA 2914805A CA 2914805 A CA2914805 A CA 2914805A CA 2914805 C CA2914805 C CA 2914805C
Authority
CA
Canada
Prior art keywords
bioactive agent
matrix
polymeric matrix
agent
forming material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2914805A
Other languages
English (en)
French (fr)
Other versions
CA2914805A1 (en
Inventor
John Dallas Pruitt
Lynn Cook Winterton
John Martin Lally
Original Assignee
Novartis AG
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG, Alcon Inc filed Critical Novartis AG
Publication of CA2914805A1 publication Critical patent/CA2914805A1/en
Application granted granted Critical
Publication of CA2914805C publication Critical patent/CA2914805C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C7/00—Optical parts
    • G02C7/02—Lenses; Lens systems ; Methods of designing lenses
    • G02C7/04—Contact lenses for the eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2914805A 2006-11-06 2007-11-05 Ocular devices and methods of making and using thereof Expired - Fee Related CA2914805C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86442806P 2006-11-06 2006-11-06
US60/864,428 2006-11-06
CA2668576A CA2668576C (en) 2006-11-06 2007-11-05 Ocular devices and methods of making and using thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2668576A Division CA2668576C (en) 2006-11-06 2007-11-05 Ocular devices and methods of making and using thereof

Publications (2)

Publication Number Publication Date
CA2914805A1 CA2914805A1 (en) 2008-06-19
CA2914805C true CA2914805C (en) 2017-12-12

Family

ID=39284102

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2914805A Expired - Fee Related CA2914805C (en) 2006-11-06 2007-11-05 Ocular devices and methods of making and using thereof
CA2668576A Expired - Fee Related CA2668576C (en) 2006-11-06 2007-11-05 Ocular devices and methods of making and using thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2668576A Expired - Fee Related CA2668576C (en) 2006-11-06 2007-11-05 Ocular devices and methods of making and using thereof

Country Status (15)

Country Link
US (1) US20080124376A1 (enExample)
EP (1) EP2094235A2 (enExample)
JP (1) JP5586956B2 (enExample)
KR (1) KR101454041B1 (enExample)
CN (1) CN101534793A (enExample)
AR (1) AR063561A1 (enExample)
AU (1) AU2007332930B2 (enExample)
BR (1) BRPI0718543A2 (enExample)
CA (2) CA2914805C (enExample)
MX (1) MX2009004365A (enExample)
NO (1) NO20092101L (enExample)
RU (1) RU2450802C2 (enExample)
TW (1) TWI476022B (enExample)
WO (1) WO2008073193A2 (enExample)
ZA (1) ZA200901842B (enExample)

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US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
JP5591226B2 (ja) 2008-05-12 2014-09-17 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 眼内薬物送達装置および関連する方法
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
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Also Published As

Publication number Publication date
AR063561A1 (es) 2009-02-04
TW200826985A (en) 2008-07-01
RU2450802C2 (ru) 2012-05-20
CA2668576A1 (en) 2008-06-19
NO20092101L (no) 2009-06-05
ZA200901842B (en) 2010-05-26
WO2008073193A2 (en) 2008-06-19
MX2009004365A (es) 2009-05-05
BRPI0718543A2 (pt) 2013-11-12
US20080124376A1 (en) 2008-05-29
CA2668576C (en) 2016-03-22
WO2008073193A3 (en) 2009-03-26
RU2009121444A (ru) 2010-12-20
JP2010508902A (ja) 2010-03-25
KR101454041B1 (ko) 2014-10-27
KR20090083901A (ko) 2009-08-04
AU2007332930B2 (en) 2011-03-17
TWI476022B (zh) 2015-03-11
EP2094235A2 (en) 2009-09-02
JP5586956B2 (ja) 2014-09-10
AU2007332930A1 (en) 2008-06-19
CA2914805A1 (en) 2008-06-19
CN101534793A (zh) 2009-09-16

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