CA2910328C - Skin substitutes and methods for hair follicle neogenesis - Google Patents

Skin substitutes and methods for hair follicle neogenesis Download PDF

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Publication number
CA2910328C
CA2910328C CA2910328A CA2910328A CA2910328C CA 2910328 C CA2910328 C CA 2910328C CA 2910328 A CA2910328 A CA 2910328A CA 2910328 A CA2910328 A CA 2910328A CA 2910328 C CA2910328 C CA 2910328C
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Canada
Prior art keywords
cells
skin
dermal
hair
human
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CA2910328A
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English (en)
French (fr)
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CA2910328A1 (en
Inventor
Rajesh Thangapazham
Thomas N. Darling
Shaowei Li
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Henry M. Jackson Foundation
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Henry M. Jackson Foundation
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2910328A 2013-05-03 2014-05-01 Skin substitutes and methods for hair follicle neogenesis Active CA2910328C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361819332P 2013-05-03 2013-05-03
US61/819,332 2013-05-03
PCT/US2014/036351 WO2014179559A1 (en) 2013-05-03 2014-05-01 Skin substitutes and methods for hair follicle neogenesis

Publications (2)

Publication Number Publication Date
CA2910328A1 CA2910328A1 (en) 2014-11-06
CA2910328C true CA2910328C (en) 2019-10-22

Family

ID=50896543

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2910328A Active CA2910328C (en) 2013-05-03 2014-05-01 Skin substitutes and methods for hair follicle neogenesis

Country Status (6)

Country Link
US (1) US10478526B2 (enExample)
EP (1) EP2991692B1 (enExample)
JP (1) JP6469655B2 (enExample)
AU (2) AU2014259787B2 (enExample)
CA (1) CA2910328C (enExample)
WO (1) WO2014179559A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6377759B2 (ja) * 2014-03-14 2018-08-22 株式会社ソニー・インタラクティブエンタテインメント ヘッドマウントディスプレイ（ｈｍｄ）の追跡及びｈｍｄのヘッドバンドの調整のための校正方法及びシステム
US10716808B2 (en) * 2014-07-09 2020-07-21 Sanford Burnham Prebys Medical Discovery Institute Methods and compositions to modulate hair growth
CA2972094C (en) 2015-01-12 2023-10-24 Wake Forest University Health Sciences Multi-layer skin substitute products and methods of making and using the same
ES2625768T3 (es) * 2015-03-26 2017-07-20 Université De Bordeaux Método de reconstrucción de piel
JP6425319B2 (ja) * 2015-10-30 2018-11-28 国立大学法人横浜国立大学 複数の再生毛包原基の製造方法、毛包組織含有シートの製造方法、毛包組織含有シート及び培養基板の使用
DE102015119877B4 (de) * 2015-11-17 2017-09-21 Technische Universität Berlin Verfahren zur Herstellung eines Hautäquivalents sowie dessen Verwendung für in vitro Tests und in vivo Transplantate
EP3420075A4 (en) 2016-02-23 2019-10-16 Chaya Brodie GENERATION OF CANCER STEM CELLS AND USE THEREOF
EP3473706B1 (en) * 2016-06-17 2025-09-10 National University Corporation Yokohama National University Cell-embedded beads for hair regeneration and method for producing same, and kit for hair regeneration
CA3028357A1 (en) * 2016-06-21 2017-12-28 Organ Technologies, Inc. Method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores
KR20190077407A (ko) * 2016-11-10 2019-07-03 오가노보, 인크. 바이오프린팅된 모발 모낭 및 그의 용도
US12234478B2 (en) * 2018-05-07 2025-02-25 Reelabs Pvt. Ltd. Method of autologous primary hair follicles preparation in 3D culture
JP7142840B2 (ja) 2018-05-16 2022-09-28 国立大学法人横浜国立大学 細胞含有ハイドロゲル体及びその製造方法
JP7702229B2 (ja) * 2018-11-19 2025-07-03 株式会社 資生堂 毛包を有するヒト皮膚組織を再構成するための組成物、ヒト皮膚組織モデル動物およびその製造方法
WO2020225934A1 (ja) 2019-05-07 2020-11-12 国立大学法人横浜国立大学 毛包原基及びその製造方法
KR102224079B1 (ko) * 2020-08-31 2021-03-05 한국화학연구원 산업부생가스로부터 일산화탄소 회수 시스템 및 회수 방법
CN117616114A (zh) * 2021-05-27 2024-02-27 香港大学 生物工程真皮乳头和毛囊以及相关产品、方法和应用

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GB8604360D0 (en) 1986-02-21 1986-03-26 Univ Dundee Stimulation of hair growth
IL95429A (en) 1989-09-15 1997-09-30 Organogenesis Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production
CA2080693C (en) 1990-04-24 2001-11-27 Mark Eisenberg Composite living skin equivalents
US5693332C1 (en) 1995-08-11 2001-01-09 Univ California Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure
SE9701162D0 (sv) 1997-03-27 1997-03-27 Karolinska Innovations Ab New use II
US5968546A (en) 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US5989837A (en) 1998-07-13 1999-11-23 Wisconsin Alumni Research Foundation Immortalized human keratinocyte cell line
BR9915476A (pt) 1998-11-19 2002-01-02 Organogenesis Inc Construtos de tecidos feitos por bioengenharia e métodos para a sua produção e utilização
DE60129799T2 (de) 2000-03-31 2008-04-30 The General Hospital Corp., Boston Verfahren zur steigerung des haarwuchses durch wnt polypeptid
EP1339831B1 (en) 2000-12-08 2007-02-21 Xgene Corporation In vitro synthesis of a layered cell sorted tissue
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
DE10162814B4 (de) * 2001-12-19 2005-06-23 Henkel Kgaa Rekonstruiertes Haarfollikelmodell
WO2003055990A2 (en) 2001-12-21 2003-07-10 Pharmagap Inc. Method for culturing and expansion of mammalian undifferentiated epidermal keratinocytes exhibiting stem cell characteristics
US20040068284A1 (en) 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
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US20080311093A1 (en) * 2006-12-07 2008-12-18 American Symbolic, Llc Stem cell secretions and related methods
US20090143418A1 (en) 2007-11-30 2009-06-04 The Regents Of The University Of Michigan Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions
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EP2105499A1 (en) * 2008-03-28 2009-09-30 Technische Universität Berlin Methods for producing de novo papillae and hair microfollicles and their use for in vitro tests and in vivo implantations
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CN103502440B (zh) 2011-02-24 2016-06-29 株式会社器官再生工学 毛发颜色受控制的移植用再生毛囊原基的制造方法、包含移植用再生毛囊原基的组合物和再生毛囊原基的移植方法
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Also Published As

Publication number Publication date
JP6469655B2 (ja) 2019-02-13
AU2018201536A1 (en) 2018-03-22
AU2014259787A1 (en) 2015-11-12
US10478526B2 (en) 2019-11-19
JP2016522682A (ja) 2016-08-04
AU2018201536B2 (en) 2019-08-22
CA2910328A1 (en) 2014-11-06
WO2014179559A1 (en) 2014-11-06
EP2991692B1 (en) 2019-08-21
EP2991692A1 (en) 2016-03-09
AU2014259787B2 (en) 2018-03-08
US20160184481A1 (en) 2016-06-30

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