CA2903473A1 - Histone demethylase inhibitors - Google Patents
Histone demethylase inhibitors Download PDFInfo
- Publication number
- CA2903473A1 CA2903473A1 CA2903473A CA2903473A CA2903473A1 CA 2903473 A1 CA2903473 A1 CA 2903473A1 CA 2903473 A CA2903473 A CA 2903473A CA 2903473 A CA2903473 A CA 2903473A CA 2903473 A1 CA2903473 A1 CA 2903473A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pyridine
- pyrrolo
- formula
- embodiment provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010074870 Histone Demethylases Proteins 0.000 title claims abstract description 22
- 102000008157 Histone Demethylases Human genes 0.000 title claims abstract description 22
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- 125000000217 alkyl group Chemical group 0.000 claims description 108
- 125000001072 heteroaryl group Chemical group 0.000 claims description 75
- 125000000623 heterocyclic group Chemical group 0.000 claims description 75
- 125000003118 aryl group Chemical group 0.000 claims description 70
- 150000003839 salts Chemical class 0.000 claims description 46
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 29
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 125000003282 alkyl amino group Chemical group 0.000 claims description 16
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- 230000002401 inhibitory effect Effects 0.000 claims description 9
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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Applications Claiming Priority (3)
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| US201361778193P | 2013-03-12 | 2013-03-12 | |
| US61/778,193 | 2013-03-12 | ||
| PCT/US2014/023273 WO2014164708A1 (en) | 2013-03-12 | 2014-03-11 | Histone dementhylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2903473A1 true CA2903473A1 (en) | 2014-10-09 |
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Family Applications (1)
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|---|---|---|---|
| CA2903473A Abandoned CA2903473A1 (en) | 2013-03-12 | 2014-03-11 | Histone demethylase inhibitors |
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| EP (1) | EP2968282B1 (enExample) |
| JP (1) | JP6320506B2 (enExample) |
| AU (1) | AU2014249050B2 (enExample) |
| CA (1) | CA2903473A1 (enExample) |
| WO (1) | WO2014164708A1 (enExample) |
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| US10030017B2 (en) | 2014-09-17 | 2018-07-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| ES2751464T3 (es) | 2014-09-17 | 2020-03-31 | Celgene Quanticel Res Inc | Inhibidores de histona desmetilasa |
| CN107912040B (zh) * | 2014-10-10 | 2021-04-06 | 基因泰克公司 | 作为组蛋白脱甲基酶抑制剂的吡咯烷酰胺化合物 |
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| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
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| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
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| DE10152306A1 (de) * | 2001-10-26 | 2003-07-24 | Asta Medica Ag | 2-Acylindolderivate mit neuen therapeutisch wertvollen Eigenschaften |
| PE20050206A1 (es) * | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
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| US8093220B2 (en) * | 2006-12-04 | 2012-01-10 | Novartis Ag | Combination of an HDAC inhibitor and an antimetabolite |
| JP2010526048A (ja) * | 2007-05-04 | 2010-07-29 | アストラゼネカ アクチボラグ | アミノ−チアゾリル−ピリミジン誘導体、および癌の治療のための該誘導体の使用 |
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| DE102008052943A1 (de) * | 2008-10-23 | 2010-04-29 | Merck Patent Gmbh | Azaindolderivate |
| JP2012107001A (ja) * | 2010-10-22 | 2012-06-07 | Shionogi & Co Ltd | インドールアミド化合物を含有する医薬 |
| LT2744330T (lt) * | 2011-08-15 | 2020-10-26 | University Of Utah Research Foundation | Pakeisti (e)-n`-(1-feniletilideno) benzohidrazido analogai, kaip histonų demetilazės inhibitoriai |
| WO2013028999A1 (en) * | 2011-08-24 | 2013-02-28 | The Trustees Of Columbia University In The City Of New York | Small molecule inducers of gdnf as potential new therapeutics for neuropsychiatric disorders |
| WO2013143597A1 (en) | 2012-03-29 | 2013-10-03 | Glaxo Group Limited | Demethylase enzymes inhibitors |
| SMT201800070T1 (it) | 2012-12-19 | 2018-03-08 | Celgene Quanticel Res Inc | Inibiorti di istone demetilasi |
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| ES2751464T3 (es) | 2014-09-17 | 2020-03-31 | Celgene Quanticel Res Inc | Inhibidores de histona desmetilasa |
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| WO2014164708A1 (en) | 2014-10-09 |
| US20170313702A1 (en) | 2017-11-02 |
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| US10174026B2 (en) | 2019-01-08 |
| US20190092771A1 (en) | 2019-03-28 |
| EP2968282B1 (en) | 2018-05-09 |
| US20180105521A1 (en) | 2018-04-19 |
| US9873697B2 (en) | 2018-01-23 |
| AU2014249050B2 (en) | 2017-10-05 |
| JP6320506B2 (ja) | 2018-05-09 |
| AU2014249050A1 (en) | 2015-09-17 |
| US10494369B2 (en) | 2019-12-03 |
| US20160194315A1 (en) | 2016-07-07 |
| JP2016516699A (ja) | 2016-06-09 |
| EP2968282A1 (en) | 2016-01-20 |
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