CA2894511C - Methods for high throughput receptor:ligand identification - Google Patents

Methods for high throughput receptor:ligand identification Download PDF

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Publication number
CA2894511C
CA2894511C CA2894511A CA2894511A CA2894511C CA 2894511 C CA2894511 C CA 2894511C CA 2894511 A CA2894511 A CA 2894511A CA 2894511 A CA2894511 A CA 2894511A CA 2894511 C CA2894511 C CA 2894511C
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protein
cell
cells
polypeptide
mutant
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French (fr)
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CA2894511A1 (en
Inventor
Steven C. Almo
Ronald D. Seidel, Iii
Brandan S. Hillerich
Sarah C. Garrett-Thomson
James D. Love
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Albert Einstein College of Medicine
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Albert Einstein College of Medicine
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
CA2894511A 2012-12-11 2013-12-05 Methods for high throughput receptor:ligand identification Active CA2894511C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261735791P 2012-12-11 2012-12-11
US61/735,791 2012-12-11
US201361833588P 2013-06-11 2013-06-11
US61/833,588 2013-06-11
PCT/US2013/073275 WO2014093118A1 (en) 2012-12-11 2013-12-05 Methods for high throughput receptor:ligand identification

Publications (2)

Publication Number Publication Date
CA2894511A1 CA2894511A1 (en) 2014-06-19
CA2894511C true CA2894511C (en) 2021-12-07

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Family Applications (1)

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CA2894511A Active CA2894511C (en) 2012-12-11 2013-12-05 Methods for high throughput receptor:ligand identification

Country Status (11)

Country Link
US (2) US10048271B2 (https=)
EP (2) EP3640375A3 (https=)
JP (2) JP2016500255A (https=)
KR (1) KR102208505B1 (https=)
CN (2) CN109324190A (https=)
AU (2) AU2013359907B2 (https=)
BR (1) BR112015013557B1 (https=)
CA (1) CA2894511C (https=)
IL (2) IL239096B (https=)
SG (2) SG11201504558TA (https=)
WO (1) WO2014093118A1 (https=)

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Publication number Publication date
EP3640375A3 (en) 2020-07-29
SG10201808463RA (en) 2018-11-29
JP2016500255A (ja) 2016-01-12
CN105121715A (zh) 2015-12-02
CA2894511A1 (en) 2014-06-19
EP2931949A1 (en) 2015-10-21
US11226339B2 (en) 2022-01-18
SG11201504558TA (en) 2015-07-30
BR112015013557A2 (pt) 2020-01-14
KR20150094674A (ko) 2015-08-19
AU2013359907B2 (en) 2018-01-18
JP7128792B2 (ja) 2022-08-31
IL239096A0 (en) 2015-07-30
AU2013359907A1 (en) 2015-06-18
AU2018201812B2 (en) 2020-09-10
EP2931949A4 (en) 2016-07-27
US20160011204A1 (en) 2016-01-14
CN109324190A (zh) 2019-02-12
JP2020043860A (ja) 2020-03-26
IL262785B (en) 2020-04-30
IL262785A (en) 2018-12-31
EP3640375A2 (en) 2020-04-22
IL239096B (en) 2019-03-31
EP2931949B1 (en) 2019-09-18
HK1218144A1 (zh) 2017-02-03
BR112015013557B1 (pt) 2021-12-14
KR102208505B1 (ko) 2021-01-27
WO2014093118A1 (en) 2014-06-19
US20200011875A1 (en) 2020-01-09
CN105121715B (zh) 2018-10-26
US10048271B2 (en) 2018-08-14
AU2018201812A1 (en) 2018-04-05

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