CA2894202A1 - Antimicrobial compounds, their synthesis and applications thereof - Google Patents

Antimicrobial compounds, their synthesis and applications thereof Download PDF

Info

Publication number
CA2894202A1
CA2894202A1 CA2894202A CA2894202A CA2894202A1 CA 2894202 A1 CA2894202 A1 CA 2894202A1 CA 2894202 A CA2894202 A CA 2894202A CA 2894202 A CA2894202 A CA 2894202A CA 2894202 A1 CA2894202 A1 CA 2894202A1
Authority
CA
Canada
Prior art keywords
lys
boc
group
compound
str
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2894202A
Other languages
English (en)
French (fr)
Inventor
Jayanta Haldar
Chandradhish GHOSH
Goutham Belagula MANJUNATH
Padma AKKAPEDDI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Secretary of State for Health
Jawaharial Nehru Centre for Advanced Scientific Research
Original Assignee
UK Secretary of State for Health
Jawaharial Nehru Centre for Advanced Scientific Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Secretary of State for Health, Jawaharial Nehru Centre for Advanced Scientific Research filed Critical UK Secretary of State for Health
Publication of CA2894202A1 publication Critical patent/CA2894202A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2894202A 2012-12-18 2013-12-18 Antimicrobial compounds, their synthesis and applications thereof Abandoned CA2894202A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN5299/CHE/2012 2012-12-18
IN5299CH2012 2012-12-18
PCT/IB2013/061090 WO2014097178A1 (en) 2012-12-18 2013-12-18 Antimicrobial compounds, their synthesis and applications thereof

Publications (1)

Publication Number Publication Date
CA2894202A1 true CA2894202A1 (en) 2014-06-26

Family

ID=54148251

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2894202A Abandoned CA2894202A1 (en) 2012-12-18 2013-12-18 Antimicrobial compounds, their synthesis and applications thereof

Country Status (9)

Country Link
US (1) US9783490B2 (https=)
EP (1) EP2934563B1 (https=)
JP (1) JP6533466B2 (https=)
CN (1) CN104981249B (https=)
AU (1) AU2013365769B2 (https=)
BR (1) BR112015014391B1 (https=)
CA (1) CA2894202A1 (https=)
HK (1) HK1210437A1 (https=)
WO (1) WO2014097178A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566149B (zh) * 2016-03-02 2017-05-24 郑州大学 具有抗菌活性的查尔酮阳离子抗菌肽模拟物及其制备方法
CN106995384B (zh) * 2017-04-21 2018-12-11 郑州大学 具有抗菌活性的二烷基阳离子两亲性抗菌肽模拟物及其制备方法
US20200354413A1 (en) 2017-12-15 2020-11-12 Dana-Farber Cancer Institute, Inc. Stabilized peptide-mediated targeted protein degradation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59309867D1 (de) 1992-09-03 1999-12-16 Boehringer Ingelheim Pharma Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
AU1441195A (en) * 1993-12-30 1995-07-17 Smithkline Beecham Corporation Phenylmethyl hexanamides, and the use thereof
US5663148A (en) 1994-07-12 1997-09-02 Abbott Laboratories Anaphylatoxin receptor ligands containing lipophilic residues
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
DE69612962T2 (de) * 1995-12-12 2001-11-15 Taiho Pharmaceutical Co. Ltd., Tokio/Tokyo Epoxysuccinamid-derivate oder deren salze und medikamente die diese enthalten
CA2217550A1 (en) * 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
BR9813554A (pt) * 1997-12-12 2001-07-24 Fuji Yakuhin Kogyo Kk Composto, uso do mesmo, processo para produzi-lo, composição farmacêutica ou veterinária, e, inibidor de metaloproteinase
WO2001040198A2 (fr) * 1999-11-30 2001-06-07 Aventis Pharma S.A. Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
JP2002161084A (ja) * 2000-11-28 2002-06-04 Sumitomo Pharmaceut Co Ltd 複素環誘導体
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
GB0512751D0 (en) * 2005-06-22 2005-07-27 Glaxo Group Ltd New adjuvant
US8097582B2 (en) 2006-05-09 2012-01-17 Neobiotics Ab Peptide derivatives useful as antimicrobial agents and for treating wounds
AU2007304847A1 (en) * 2006-10-04 2008-04-10 Inimex Pharmaceuticals, Inc. Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity
EP2091917A1 (en) * 2006-12-11 2009-08-26 Wyeth a Corporation of the State of Delaware Ion channel modulators
CN102757477B (zh) * 2011-04-27 2014-09-03 首都医科大学 烯丙基半胱氨酰氨基酸甲酯衍生物及其合成方法和应用
EP2709619B1 (en) * 2011-05-16 2017-10-11 Cellceutix Corporation Compounds for use in treatment of mucositis

Also Published As

Publication number Publication date
US9783490B2 (en) 2017-10-10
AU2013365769B2 (en) 2018-03-15
CN104981249B (zh) 2018-06-19
JP6533466B2 (ja) 2019-06-19
US20150329478A1 (en) 2015-11-19
EP2934563A1 (en) 2015-10-28
EP2934563B1 (en) 2020-07-08
BR112015014391A2 (pt) 2017-07-11
WO2014097178A1 (en) 2014-06-26
CN104981249A (zh) 2015-10-14
AU2013365769A1 (en) 2015-07-02
JP2016504330A (ja) 2016-02-12
BR112015014391B1 (pt) 2020-11-03
HK1210437A1 (en) 2016-04-22
EP2934563A4 (en) 2016-08-17

Similar Documents

Publication Publication Date Title
US11325955B2 (en) Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections
CA2694461C (en) Antibiotic peptides
US8927029B2 (en) Inhibition of biofilms in plants with imidazole derivatives
RU2463308C2 (ru) Циклические противомикробные пептиды
JP4194941B2 (ja) マガイニン誘導体
US8541365B2 (en) Dendrimeric compounds comprising amino acids, hyperbranched core compound, process for preparation of dendrimeric compounds comprising amino acids and hyperbranched core compound, and use thereof
CA2894202A1 (en) Antimicrobial compounds, their synthesis and applications thereof
CN117209568B (zh) 一种抗胞内细菌的嵌合抗菌肽pf-ir及其制备方法和应用
CN110650970A (zh) 抗菌肽及其药品
JP2021510148A (ja) 新規抗生物質およびその使用方法
WO2019079759A1 (en) ANTI-PERSISTENCE AND ANTI-VIRULENCE COMPOUNDS WITH BROAD SPECTRUM
JPH0570495A (ja) 環式ヘキサペプチド化合物
CN118388589A (zh) 一种抗胞内细菌的细胞穿透型抗菌肽及其制备方法和应用
CN1943341B (zh) 氨基酸与农药的藕合物及其制备方法与作为农药的应用
NZ741118B2 (en) Compounds and therapeutic uses thereof
NZ741118A (en) Compounds and therapeutic uses thereof

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20181119

FZDE Discontinued

Effective date: 20220429